NALP2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: NALP2_HUMAN
• UniProt AC: Q9NX02
• Protein Name: NACHT, LRR and PYD domains-containing protein 2
• Gene Name: NLRP2
• Organism: Homo sapiens (Human).
• Sequence Length: 1062
• Subcellular Localization: Cytoplasm .
• Protein Description: Suppresses TNF- and CD40-induced NFKB1 activity at the level of the IKK complex, by inhibiting NFKBIA degradation induced by TNF. When associated with PYCARD, activates CASP1, leading to the secretion of mature proinflammatory cytokine IL1B. May be a component of the inflammasome, a protein complex which also includes PYCARD, CARD8 and CASP1 and whose function would be the activation of proinflammatory caspases..
• Protein Sequence: MVSSAQMGFNLQALLEQLSQDELSKFKYLITTFSLAHELQKIPHKEVDKADGKQLVEILTTHCDSYWVEMASLQVFEKMHRMDLSERAKDEVREAALKSFNKRKPLSLGITRKERPPLDVDEMLERFKTEAQAFTETKGNVICLGKEVFKGKKPDKDNRCRYILKTKFREMWKSWPGDSKEVQVMAERYKMLIPFSNPRVLPGPFSYTVVLYGPAGLGKTTLAQKLMLDWAEDNLIHKFKYAFYLSCRELSRLGPCSFAELVFRDWPELQDDIPHILAQARKILFVIDGFDELGAAPGALIEDICGDWEKKKPVPVLLGSLLNRVMLPKAALLVTTRPRALRDLRILAEEPIYIRVEGFLEEDRRAYFLRHFGDEDQAMRAFELMRSNAALFQLGSAPAVCWIVCTTLKLQMEKGEDPVPTCLTRTGLFLRFLCSRFPQGAQLRGALRTLSLLAAQGLWAQTSVLHREDLERLGVQESDLRLFLDGDILRQDRVSKGCYSFIHLSFQQFLTALFYTLEKEEEEDRDGHTWDIGDVQKLLSGVERLRNPDLIQAGYYSFGLANEKRAKELEATFGCRMSPDIKQELLRCDISCKGGHSTVTDLQELLGCLYESQEEELVKEVMAQFKEISLHLNAVDVVPSSFCVKHCRNLQKMSLQVIKENLPENVTASESDAEVERSQDDQHMLPFWTDLCSIFGSNKDLMGLAINDSFLSASLVRILCEQIASDTCHLQRVVFKNISPADAHRNLCLALRGHKTVTYLTLQGNDQDDMFPALCEVLRHPECNLRYLGLVSCSATTQQWADLSLALEVNQSLTCVNLSDNELLDEGAKLLYTTLRHPKCFLQRLSLENCHLTEANCKDLAAVLVVSRELTHLCLAKNPIGNTGVKFLCEGLRYPECKLQTLVLWNCDITSDGCCDLTKLLQEKSSLLCLDLGLNHIGVKGMKFLCEALRKPLCNLRCLWLWGCSIPPFSCEDLCSALSCNQSLVTLDLGQNPLGSSGVKMLFETLTCSSGTLRTLRLKIDDFNDELNKLLEEIEEKNPQLIIDTEKHHPWAERPSSHDFMI

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
19	Phosphorylation	QALLEQLSQDELSKF HHHHHHHCHHHHHHH	34.97	24043423
24	Phosphorylation	QLSQDELSKFKYLIT HHCHHHHHHHHHHHH	33.72	24043423
99	Phosphorylation	VREAALKSFNKRKPL HHHHHHHHHCCCCCC	34.60	26434776
107	Phosphorylation	FNKRKPLSLGITRKE HCCCCCCCCCCCCCC	32.83	25106551
111	Phosphorylation	KPLSLGITRKERPPL CCCCCCCCCCCCCCC	33.61	27794612
128 (in isoform 1)	Ubiquitination	-	52.24	21906983
128	Ubiquitination	DEMLERFKTEAQAFT HHHHHHHHHHHHHHH	52.24	21906983
128 (in isoform 3)	Ubiquitination	-	52.24	21906983
129	Phosphorylation	EMLERFKTEAQAFTE HHHHHHHHHHHHHHH	33.56	21406692
135	Phosphorylation	KTEAQAFTETKGNVI HHHHHHHHHCCCCEE	45.84	21406692
137	Phosphorylation	EAQAFTETKGNVICL HHHHHHHCCCCEEEE	40.99	21406692
189	Phosphorylation	VQVMAERYKMLIPFS HHHHHHHHCEEEECC	7.70	-
320	Phosphorylation	PVPVLLGSLLNRVML CHHHHHHHHHHHCCC	29.65	-
478	Phosphorylation	ERLGVQESDLRLFLD HHHCCCHHHEEHEEC	25.50	24905233
495	Phosphorylation	ILRQDRVSKGCYSFI HHCCCCCCCCCHHHH	24.99	-
543 (in isoform 4)	Ubiquitination	-	49.91	21906983
545 (in isoform 2)	Ubiquitination	-	3.82	21906983
567 (in isoform 1)	Ubiquitination	-	67.85	21906983
567 (in isoform 3)	Ubiquitination	-	67.85	21906983
567	Ubiquitination	LANEKRAKELEATFG CCCHHHHHHHHHHHC	67.85	21906983
572	Phosphorylation	RAKELEATFGCRMSP HHHHHHHHHCCCCCC	15.93	29514088
578	Phosphorylation	ATFGCRMSPDIKQEL HHHCCCCCCCHHHHH	10.48	29514088
635 (in isoform 4)	Ubiquitination	-	5.81	21906983
637 (in isoform 2)	Ubiquitination	-	5.69	21906983
654	Phosphorylation	CRNLQKMSLQVIKEN HHHHHHCCHHHHHHH	23.76	29083192
659 (in isoform 3)	Ubiquitination	-	41.51	21906983
659	Ubiquitination	KMSLQVIKENLPENV HCCHHHHHHHCCCCC	41.51	21906983
659 (in isoform 1)	Ubiquitination	-	41.51	21906983
667	Phosphorylation	ENLPENVTASESDAE HHCCCCCCCCCCHHH	35.73	23186163
669	Phosphorylation	LPENVTASESDAEVE CCCCCCCCCCHHHHH	28.41	29978859
671	O-linked_Glycosylation	ENVTASESDAEVERS CCCCCCCCHHHHHHC	39.36	30620550
671	Phosphorylation	ENVTASESDAEVERS CCCCCCCCHHHHHHC	39.36	28355574
736	Ubiquitination	HLQRVVFKNISPADA CCEEEHHCCCCHHHH	41.59	-
756	Phosphorylation	LALRGHKTVTYLTLQ HHHCCCCEEEEEEEC	16.65	28270605
758	Phosphorylation	LRGHKTVTYLTLQGN HCCCCEEEEEEECCC	20.32	28270605
759	Phosphorylation	RGHKTVTYLTLQGND CCCCEEEEEEECCCC	8.05	28270605
761	Phosphorylation	HKTVTYLTLQGNDQD CCEEEEEEECCCCCC	13.46	28270605
832	Phosphorylation	DEGAKLLYTTLRHPK HHHHHHHHHHHCCHH	14.23	27642862
834	Phosphorylation	GAKLLYTTLRHPKCF HHHHHHHHHCCHHHH	14.29	-
867	Phosphorylation	LAAVLVVSRELTHLC HHHHHHHCHHHHHHH	16.74	24719451
1013 (in isoform 4)	Ubiquitination	-	4.49	21906983
1015 (in isoform 2)	Ubiquitination	-	21.24	21906983
1037 (in isoform 1)	Ubiquitination	-	62.22	21906983
1037	Ubiquitination	LLEEIEEKNPQLIID HHHHHHHHCCCEEEE	62.22	2190698

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of NALP2_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of NALP2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of NALP2_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
HS90A_HUMAN	HSP90AA1	physical	17435760
SGT1_HUMAN	SUGT1	physical	17435760
FAF1_HUMAN	FAF1	physical	17046979
A4_HUMAN	APP	physical	21832049
G3P_HUMAN	GAPDH	physical	26344197
LARP1_HUMAN	LARP1	physical	26344197
TPP1_HUMAN	TPP1	physical	26496610
RBBP6_HUMAN	RBBP6	physical	26496610
TAF13_HUMAN	TAF13	physical	26496610
TTF1_HUMAN	TTF1	physical	26496610
BECN1_HUMAN	BECN1	physical	26496610
BCL7B_HUMAN	BCL7B	physical	26496610
CRIPT_HUMAN	CRIPT	physical	26496610
NALP5_HUMAN	NLRP5	physical	26496610

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.