NALP5_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: NALP5_HUMAN
• UniProt AC: P59047
• Protein Name: NACHT, LRR and PYD domains-containing protein 5
• Gene Name: NLRP5
• Organism: Homo sapiens (Human).
• Sequence Length: 1200
• Subcellular Localization: Mitochondrion. Nucleus, nucleolus. Cytoplasm. In the subcortical cytoplasm of early embryos from the 1-cell to the blastocyst stages. From the 2-cell stage, still detected in the subcortex, but excluded from cell-cell contact regions (By similarity).
• Protein Description: As a member of the subcortical maternal complex (SCMC), plays an essential role for zygotes to progress beyond the first embryonic cell divisions..
• Protein Sequence: MKVAGGLELGAAALLSASPRALVTLSTGPTCSILPKNPLFPQNLSSQPCIKMEGDKSLTFSSYGLQWCLYELDKEEFQTFKELLKKKSSESTTCSIPQFEIENANVECLALLLHEYYGASLAWATSISIFENMNLRTLSEKARDDMKRHSPEDPEATMTDQGPSKEKVPGISQAVQQDSATAAETKEQEISQAMEQEGATAAETEEQEISQAMEQEGATAAETEEQGHGGDTWDYKSHVMTKFAEEEDVRRSFENTAADWPEMQTLAGAFDSDRWGFRPRTVVLHGKSGIGKSALARRIVLCWAQGGLYQGMFSYVFFLPVREMQRKKESSVTEFISREWPDSQAPVTEIMSRPERLLFIIDGFDDLGSVLNNDTKLCKDWAEKQPPFTLIRSLLRKVLLPESFLIVTVRDVGTEKLKSEVVSPRYLLVRGISGEQRIHLLLERGIGEHQKTQGLRAIMNNRELLDQCQVPAVGSLICVALQLQDVVGESVAPFNQTLTGLHAAFVFHQLTPRGVVRRCLNLEERVVLKRFCRMAVEGVWNRKSVFDGDDLMVQGLGESELRALFHMNILLPDSHCEEYYTFFHLSLQDFCAALYYVLEGLEIEPALCPLYVEKTKRSMELKQAGFHIHSLWMKRFLFGLVSEDVRRPLEVLLGCPVPLGVKQKLLHWVSLLGQQPNATTPGDTLDAFHCLFETQDKEFVRLALNSFQEVWLPINQNLDLIASSFCLQHCPYLRKIRVDVKGIFPRDESAEACPVVPLWMRDKTLIEEQWEDFCSMLGTHPHLRQLDLGSSILTERAMKTLCAKLRHPTCKIQTLMFRNAQITPGVQHLWRIVMANRNLRSLNLGGTHLKEEDVRMACEALKHPKCLLESLRLDCCGLTHACYLKISQILTTSPSLKSLSLAGNKVTDQGVMPLSDALRVSQCALQKLILEDCGITATGCQSLASALVSNRSLTHLCLSNNSLGNEGVNLLCRSMRLPHCSLQRLMLNQCHLDTAGCGFLALALMGNSWLTHLSLSMNPVEDNGVKLLCEVMREPSCHLQDLELVKCHLTAACCESLSCVISRSRHLKSLDLTDNALGDGGVAALCEGLKQKNSVLARLGLKACGLTSDCCEALSLALSCNRHLTSLNLVQNNFSPKGMMKLCSAFACPTSNLQIIGLWKWQYPVQIRKLLEEVQLLKPRVVIDGSWHSFDEDDRYWWKN

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
16	Phosphorylation	LGAAALLSASPRALV HHHHHHHHCCCCEEE	27.79	-
20	Dimethylation	ALLSASPRALVTLST HHHHCCCCEEEEECC	37.75	-
20	Methylation	ALLSASPRALVTLST HHHHCCCCEEEEECC	37.75	115372689
150	Phosphorylation	RDDMKRHSPEDPEAT HHHHHHCCCCCCCCC	33.74	22210691
157	Phosphorylation	SPEDPEATMTDQGPS CCCCCCCCCCCCCCC	20.95	22210691
159	Phosphorylation	EDPEATMTDQGPSKE CCCCCCCCCCCCCCC	22.33	22210691
185	Phosphorylation	DSATAAETKEQEISQ CCCHHHHHHHHHHHH	34.84	-
191	Phosphorylation	ETKEQEISQAMEQEG HHHHHHHHHHHHHCC	15.90	-
333	Phosphorylation	RKKESSVTEFISREW HHHCCCHHHHHHCCC	27.42	28152594
337	Phosphorylation	SSVTEFISREWPDSQ CCHHHHHHCCCCCCC	29.48	28152594
408	Phosphorylation	PESFLIVTVRDVGTE CCCEEEEEEEECCCH	11.66	20068231
642	Phosphorylation	RFLFGLVSEDVRRPL HHHHHHCCHHCCCCH	32.87	-
1062	Phosphorylation	ESLSCVISRSRHLKS HHHHHHHHCCCCCCC	12.10	-
1064	Phosphorylation	LSCVISRSRHLKSLD HHHHHHCCCCCCCCC	19.77	-
1135	Phosphorylation	NLVQNNFSPKGMMKL HHHCCCCCHHHHHHH	28.03	24719451

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of NALP5_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of NALP5_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of NALP5_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
DECR_HUMAN	DECR1	physical	26496610
BECN1_HUMAN	BECN1	physical	26496610
BAG2_HUMAN	BAG2	physical	26496610
STIP1_HUMAN	STIP1	physical	26496610
LRRC1_HUMAN	LRRC1	physical	26496610

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.