| UniProt ID | MUS81_MOUSE | |
|---|---|---|
| UniProt AC | Q91ZJ0 | |
| Protein Name | Crossover junction endonuclease MUS81 | |
| Gene Name | Mus81 | |
| Organism | Mus musculus (Mouse). | |
| Sequence Length | 551 | |
| Subcellular Localization | Nucleus, nucleolus. Recruited to foci of DNA damage in S-phase cells.. | |
| Protein Description | Interacts with EME1 and EME2 to form a DNA structure-specific endonuclease with substrate preference for branched DNA structures with a 5'-end at the branch nick. Typical substrates include 3'-flap structures, replication forks and nicked Holliday junctions. May be required in mitosis for the processing of stalled or collapsed replication forks.. | |
| Protein Sequence | MAEPVRLGRKRPLPVCPNPLFVRWLTEWRDEAASRGRHTRFVFQKALRSLQRYPLPLRSGKEAKILQHFGDRLCRMLDEKLKQHLASGGDHAPSSPSGKKGASKGPPEQVQDSSMPVPTQPQAGSTSVGYWPAQNSGAREILLQLYREHLNSDGHSFLTKEELLQKCAQKTPRVVPGSSKPWPALRSLLHRNLILGTHRPARYALTPEGLELAQKLAEAEGLSTRHAGFRPEEHHGEDSAVPEALSEPGTTEGAVQQRPLELRPSEYRVLLCVDIGETRGAGHRPEMLRELQRLRVPHTVRKLHVGDFVWVAQETRPRDPERPGELVLDHIVERKRLDDLCSSIIDGRFREQKFRLKRCGLGHRVYLVEEHGSVHNLSLPESTLLQAVTNTQVIDGFFVKRTMDIKESAGYLALLTKGLERLYQGHTLRSRPWGAPGAAESEAKPSTNPLCSLLTFSDFNAEAVKNKAQSVREVFARQLMQVRGLSGEKAAAVVDRYSTPASLLAAYDACATAKEQEMLLSTIKCGRLQRNLGPALSRTLYQLYCSHSPLS | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 87 | Phosphorylation | KLKQHLASGGDHAPS HHHHHHHCCCCCCCC | 50.06 | 28066266 | |
| 94 | Phosphorylation | SGGDHAPSSPSGKKG CCCCCCCCCCCCCCC | 56.52 | 25266776 | |
| 95 | Phosphorylation | GGDHAPSSPSGKKGA CCCCCCCCCCCCCCC | 23.25 | 25266776 | |
| 97 | Phosphorylation | DHAPSSPSGKKGASK CCCCCCCCCCCCCCC | 66.25 | 25266776 | |
| 546 | Phosphorylation | TLYQLYCSHSPLS-- HHHHHHHHCCCCC-- | 17.28 | 26643407 | |
| 548 | Phosphorylation | YQLYCSHSPLS---- HHHHHHCCCCC---- | 15.96 | 26643407 | |
| 551 | Phosphorylation | YCSHSPLS------- HHHCCCCC------- | 41.37 | 26643407 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of MUS81_MOUSE !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of MUS81_MOUSE !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of MUS81_MOUSE !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
| ANX11_HUMAN | ANXA11 | physical | 26496610 | |
| BTF3_HUMAN | BTF3 | physical | 26496610 | |
| XPF_HUMAN | ERCC4 | physical | 26496610 | |
| MGAT1_HUMAN | MGAT1 | physical | 26496610 | |
| IKBL1_HUMAN | NFKBIL1 | physical | 26496610 | |
| HERC2_HUMAN | HERC2 | physical | 26496610 | |
| KIF1B_HUMAN | KIF1B | physical | 26496610 | |
| GTPB2_HUMAN | GTPBP2 | physical | 26496610 | |
| CNTLN_HUMAN | CNTLN | physical | 26496610 | |
| RBM26_HUMAN | RBM26 | physical | 26496610 | |
| SLX4_HUMAN | SLX4 | physical | 26496610 | |
| OSBL5_HUMAN | OSBPL5 | physical | 26496610 | |
| CGAS_HUMAN | MB21D1 | physical | 26496610 | |
| EME1_HUMAN | EME1 | physical | 26496610 | |
| TM189_HUMAN | TMEM189 | physical | 26496610 |
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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