LMX1B_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: LMX1B_HUMAN
• UniProt AC: O60663
• Protein Name: LIM homeobox transcription factor 1-beta
• Gene Name: LMX1B
• Organism: Homo sapiens (Human).
• Sequence Length: 402
• Subcellular Localization: Nucleus .
• Protein Description: Essential for the specification of dorsal limb fate at both the zeugopodal and autopodal levels..
• Protein Sequence: MDIATGPESLERCFPRGQTDCAKMLDGIKMEEHALRPGPATLGVLLGSDCPHPAVCEGCQRPISDRFLMRVNESSWHEECLQCAACQQALTTSCYFRDRKLYCKQDYQQLFAAKCSGCMEKIAPTEFVMRALECVYHLGCFCCCVCERQLRKGDEFVLKEGQLLCKGDYEKEKDLLSSVSPDESDSVKSEDEDGDMKPAKGQGSQSKGSGDDGKDPRRPKRPRTILTTQQRRAFKASFEVSSKPCRKVRETLAAETGLSVRVVQVWFQNQRAKMKKLARRHQQQQEQQNSQRLGQEVLSSRMEGMMASYTPLAPPQQQIVAMEQSPYGSSDPFQQGLTPPQMPGDHMNPYGNDSIFHDIDSDTSLTSLSDCFLGSSDVGSLQARVGNPIDRLYSMQSSYFAS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
5	Phosphorylation	---MDIATGPESLER ---CCCCCCHHHHHH	3.71	27251275
9	Phosphorylation	DIATGPESLERCFPR CCCCCHHHHHHHCCC	30.84	27251275
19	Phosphorylation	RCFPRGQTDCAKMLD HHCCCCCCHHHHHHC	4.92	-
29	Acetylation	AKMLDGIKMEEHALR HHHHCCCCHHHHCCC	29.32	7705573
177	Phosphorylation	EKEKDLLSSVSPDES HHHHHHHHCCCCCCC	61.36	27251275
178	Phosphorylation	KEKDLLSSVSPDESD HHHHHHHCCCCCCCC	38.91	27251275
180	Phosphorylation	KDLLSSVSPDESDSV HHHHHCCCCCCCCCC	36.00	23909892
184	Phosphorylation	SSVSPDESDSVKSED HCCCCCCCCCCCCCC	49.84	27251275
186	Phosphorylation	VSPDESDSVKSEDED CCCCCCCCCCCCCCC	42.67	23909892
189	Phosphorylation	DESDSVKSEDEDGDM CCCCCCCCCCCCCCC	70.35	27251275
209	Phosphorylation	QGSQSKGSGDDGKDP CCCCCCCCCCCCCCC	39.78	28348404
256	Phosphorylation	RETLAAETGLSVRVV HHHHHHHHCCCEEEE	47.23	17322306
259	Phosphorylation	LAAETGLSVRVVQVW HHHHHCCCEEEEEHH	40.75	24719451
300	Phosphorylation	LGQEVLSSRMEGMMA HHHHHHHHHHHHHHH	37.86	24719451
398	Phosphorylation	RLYSMQSSYFAS--- HHHHHHHHHCCC---		-
402	Phosphorylation	MQSSYFAS------- HHHHHCCC-------		-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of LMX1B_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of LMX1B_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of LMX1B_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
SSBP3_HUMAN	SSBP3	physical	20211142
A4_HUMAN	APP	physical	21832049
LDB1_HUMAN	LDB1	physical	25416956
MB211_HUMAN	MAB21L1	physical	26186194
POTEF_HUMAN	POTEF	physical	26186194
ACTB_HUMAN	ACTB	physical	26186194
PKNX2_HUMAN	PKNOX2	physical	26186194
SYPM_HUMAN	PARS2	physical	26186194
LDB1_HUMAN	LDB1	physical	26186194
PBX1_HUMAN	PBX1	physical	26186194
PBX2_HUMAN	PBX2	physical	26186194
PBX3_HUMAN	PBX3	physical	26186194
MEIS1_HUMAN	MEIS1	physical	26186194
MEIS2_HUMAN	MEIS2	physical	26186194
SSBP2_HUMAN	SSBP2	physical	26186194
SSBP4_HUMAN	SSBP4	physical	26186194
SSBP3_HUMAN	SSBP3	physical	26186194
SSBP3_HUMAN	SSBP3	physical	28514442
SSBP2_HUMAN	SSBP2	physical	28514442
SSBP4_HUMAN	SSBP4	physical	28514442
MEIS1_HUMAN	MEIS1	physical	28514442
MEIS2_HUMAN	MEIS2	physical	28514442
LDB1_HUMAN	LDB1	physical	28514442
PKNX2_HUMAN	PKNOX2	physical	28514442
PBX2_HUMAN	PBX2	physical	28514442
POTEF_HUMAN	POTEF	physical	28514442
PBX3_HUMAN	PBX3	physical	28514442
PBX1_HUMAN	PBX1	physical	28514442
MB211_HUMAN	MAB21L1	physical	28514442
ACTB_HUMAN	ACTB	physical	28514442
SYPM_HUMAN	PARS2	physical	28514442

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.