dbPTM

K1107_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	K1107_HUMAN
UniProt AC	Q9UPP5
Protein Name	Uncharacterized protein KIAA1107
Gene Name	KIAA1107
Organism	Homo sapiens (Human).
Sequence Length	1409
Subcellular Localization
Protein Description
Protein Sequence	MESDRLIISLPRVKWTEAALTMASQLQEKCIAFIVDNFSKIIQSENFALLLQSQAMSSTADLLDTILKAIEENITTENSCSLLMALDTLLNSDSTKEMGFTCKIQALRDKLWIFLVQSFYAVRHTESWKLMSTDDQQKIQAAAFDKGDDRRLGKKPIFSSSQQRKQVSDSGDIKIKSWRGNNKKECWSYLSTNKKMKSDGLGASGHSSSTNRNSINKTLKQDDVKEKDGTKIASKITKELKTGGKNVSGKPKTVTKSKTENGDKARLENMSPRQVVERSATAAAAATGQKNLLNGKGVRNQEGQISGARPKVLTGNLNVQAKAKPLKKATGKDSPCLSIAGPSSRSTDSSMEFSISTECLDEPKENGSTEEEKPSGHKLSFCDSPGQMMKNSVDSVKNSTVAIKSRPVSRVTNGTSNKKSIHEQDTNVNNSVLKKVSGKGCSEPVPQAILKKRGTSNGCTAAQQRTKSTPSNLTKTQGSQGESPNSVKSSVSSRQSDENVAKLDHNTTTEKQAPKRKMVKQVHTALPKVNAKIVAMPKNLNQSKKGETLNNKDSKQKMPPGQVISKTQPSSQRPLKHETSTVQKSMFHDVRDNNNKDSVSEQKPHKPLINLASEISDAEALQSSCRPDPQKPLNDQEKEKLALECQNISKLDKSLKHELESKQICLDKSETKFPNHKETDDCDAANICCHSVGSDNVNSKFYSTTALKYMVSNPNENSLNSNPVCDLDSTSAGQIHLISDRENQVGRKDTNKQSSIKCVEDVSLCNPERTNGTLNSAQEDKKSKVPVEGLTIPSKLSDESAMDEDKHATADSDVSSKCFSGQLSEKNSPKNMETSESPESHETPETPFVGHWNLSTGVLHQRESPESDTGSATTSSDDIKPRSEDYDAGGSQDDDGSNDRGISKCGTMLCHDFLGRSSSDTSTPEELKIYDSNLRIEVKMKKQSNNDLFQVNSTSDDEIPRKRPEIWSRSAIVHSRERENIPRGSVQFAQEIDQVSSSADETEDERSEAENVAENFSISNPAPQQFQGIINLAFEDATENECREFSANKKFKRSVLLSVDECEELGSDEGEVHTPFQASVDSFSPSDVFDGISHEHHGRTCYSRFSRESEDNILECKQNKGNSVCKNESTVLDLSSIDSSRKNKQSVSATEKKNTIDVLSSRSRQLLREDKKVNNGSNVENDIQQRSKFLDSDVKSQERPCHLDLHQREPNSDIPKNSSTKSLDSFRSQVLPQEGPVKESHSTTTEKANIALSAGDIDDCDTLAQTRMYDHRPSKTLSPIYEMDVIEAFEQKVESETHVTDMDFEDDQHFAKQDWTLLKQLLSEQDSNLDVTNSVPEDLSLAQYLINQTLLLARDSSKPQGITHIDTLNRWSELTSPLDSSASITMASFSSEDCSPQGEWTILELETQH

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
9	Phosphorylation	ESDRLIISLPRVKWT CCCCEEEECCCCCHH	25.90	24719451
16	Phosphorylation	SLPRVKWTEAALTMA ECCCCCHHHHHHHHH	15.27	29888752
21	Phosphorylation	KWTEAALTMASQLQE CHHHHHHHHHHHHHH	13.13	29888752
24	Phosphorylation	EAALTMASQLQEKCI HHHHHHHHHHHHHHH	22.17	29888752
65	Phosphorylation	STADLLDTILKAIEE CHHHHHHHHHHHHHH	28.33	-
125	Phosphorylation	SFYAVRHTESWKLMS HHHHHHCCCCCEECC	22.58	27251275
160	Phosphorylation	GKKPIFSSSQQRKQV CCCCCCCCHHHHCCC	22.78	28857561
189	Phosphorylation	NKKECWSYLSTNKKM CCHHHHHHHHCCCCC	4.71	-
191	Phosphorylation	KECWSYLSTNKKMKS HHHHHHHHCCCCCCC	23.00	-
204	Phosphorylation	KSDGLGASGHSSSTN CCCCCCCCCCCCCCC	34.93	30576142
207	Phosphorylation	GLGASGHSSSTNRNS CCCCCCCCCCCCHHH	29.52	30576142
210	Phosphorylation	ASGHSSSTNRNSINK CCCCCCCCCHHHHCH	39.90	30576142
217	Acetylation	TNRNSINKTLKQDDV CCHHHHCHHHCHHHH	54.27	7468663
224	Phosphorylation	KTLKQDDVKEKDGTK HHHCHHHHHHCCCCC	13.35	-
253	Phosphorylation	NVSGKPKTVTKSKTE CCCCCCCCCCCCCCC	41.77	-
255	Phosphorylation	SGKPKTVTKSKTENG CCCCCCCCCCCCCCC	34.53	-
259	Phosphorylation	KTVTKSKTENGDKAR CCCCCCCCCCCCHHH	41.60	-
279	Phosphorylation	PRQVVERSATAAAAA HHHHHHHHHHHHHHH	19.23	-
281	Phosphorylation	QVVERSATAAAAATG HHHHHHHHHHHHHHC	20.34	24505115
287	Phosphorylation	ATAAAAATGQKNLLN HHHHHHHHCCCCHHC	35.10	24505115
329	Phosphorylation	KAKPLKKATGKDSPC CCCCCHHCCCCCCCC	21.72	-
334	Phosphorylation	KKATGKDSPCLSIAG HHCCCCCCCCCEECC	22.46	28985074
350	Phosphorylation	SSRSTDSSMEFSIST CCCCCCCCEEEEEEH	25.74	-
354	Phosphorylation	TDSSMEFSISTECLD CCCCEEEEEEHHHCC	11.43	-
366	Phosphorylation	CLDEPKENGSTEEEK HCCCCCCCCCCCCCC	56.70	27251275
384	Phosphorylation	HKLSFCDSPGQMMKN CCCCCCCCCCCCHHC	31.92	25159151
400	Phosphorylation	VDSVKNSTVAIKSRP HHHHCCCEEEEECCC	24.29	-
405	Phosphorylation	NSTVAIKSRPVSRVT CCEEEEECCCCCEEC	35.39	17494752
409	Phosphorylation	AIKSRPVSRVTNGTS EEECCCCCEECCCCC	24.58	17494752
441	Phosphorylation	KKVSGKGCSEPVPQA HHHCCCCCCCCCCHH	4.79	27251275
479	Phosphorylation	NLTKTQGSQGESPNS CCCCCCCCCCCCCCC	25.79	-
483	Phosphorylation	TQGSQGESPNSVKSS CCCCCCCCCCCHHHC	35.88	28985074
489	Phosphorylation	ESPNSVKSSVSSRQS CCCCCHHHCCCCCCC	33.54	29449344
490	Phosphorylation	SPNSVKSSVSSRQSD CCCCHHHCCCCCCCC	21.94	29449344
492	Phosphorylation	NSVKSSVSSRQSDEN CCHHHCCCCCCCCCC	23.04	29449344
493	Phosphorylation	SVKSSVSSRQSDENV CHHHCCCCCCCCCCH	31.98	29449344
496	Phosphorylation	SSVSSRQSDENVAKL HCCCCCCCCCCHHHC	45.87	25849741
567	Phosphorylation	PGQVISKTQPSSQRP CCCEEECCCCCCCCC	38.63	27251275
570	Phosphorylation	VISKTQPSSQRPLKH EEECCCCCCCCCCCC	29.32	24719451
571	Phosphorylation	ISKTQPSSQRPLKHE EECCCCCCCCCCCCC	36.57	27251275
601	Ubiquitination	NNKDSVSEQKPHKPL CCCCCCHHCCCCCCH	61.54	-
647	Phosphorylation	KLALECQNISKLDKS HHHHHHHCHHHHCHH	52.76	-
702	Phosphorylation	DNVNSKFYSTTALKY CCCCCCCEEHHHHHH	14.62	25159151
770	Phosphorylation	SLCNPERTNGTLNSA CCCCCCCCCCCCCCC	36.02	23612710
773	Phosphorylation	NPERTNGTLNSAQED CCCCCCCCCCCCCCH	25.49	-
776	Phosphorylation	RTNGTLNSAQEDKKS CCCCCCCCCCCHHCC	34.15	-
794	Phosphorylation	VEGLTIPSKLSDESA CCCCCCCCCCCCCCC	42.23	24719451
797	Phosphorylation	LTIPSKLSDESAMDE CCCCCCCCCCCCCCC	42.97	-
800	Phosphorylation	PSKLSDESAMDEDKH CCCCCCCCCCCCCCC	33.61	-
812	Phosphorylation	DKHATADSDVSSKCF CCCCCCCCCHHHHHH	37.13	24626860
824	Phosphorylation	KCFSGQLSEKNSPKN HHHCCCCCCCCCCCC	38.34	29978859
828	Phosphorylation	GQLSEKNSPKNMETS CCCCCCCCCCCCCCC	48.60	29978859
835	Phosphorylation	SPKNMETSESPESHE CCCCCCCCCCCCCCC	23.83	28387310
836	Phosphorylation	PKNMETSESPESHET CCCCCCCCCCCCCCC	77.16	-
864	Phosphorylation	GVLHQRESPESDTGS CCEECCCCCCCCCCC	35.84	23663014
867	Phosphorylation	HQRESPESDTGSATT ECCCCCCCCCCCCCC	43.80	23663014
869	Phosphorylation	RESPESDTGSATTSS CCCCCCCCCCCCCCC	42.17	23663014
871	Phosphorylation	SPESDTGSATTSSDD CCCCCCCCCCCCCCC	25.24	23663014
873	Phosphorylation	ESDTGSATTSSDDIK CCCCCCCCCCCCCCC	28.98	23663014
874	Phosphorylation	SDTGSATTSSDDIKP CCCCCCCCCCCCCCC	26.42	23663014
875	Phosphorylation	DTGSATTSSDDIKPR CCCCCCCCCCCCCCC	27.67	23663014
876	Phosphorylation	TGSATTSSDDIKPRS CCCCCCCCCCCCCCC	36.89	23663014
883	Phosphorylation	SDDIKPRSEDYDAGG CCCCCCCCCCCCCCC	43.26	24114839
886	Phosphorylation	IKPRSEDYDAGGSQD CCCCCCCCCCCCCCC	12.02	24114839
891	Phosphorylation	EDYDAGGSQDDDGSN CCCCCCCCCCCCCCC	29.53	17525332
897	Phosphorylation	GSQDDDGSNDRGISK CCCCCCCCCCCCHHH	42.42	24114839
917	Phosphorylation	CHDFLGRSSSDTSTP HHHHHCCCCCCCCCH	32.18	28102081
918	Phosphorylation	HDFLGRSSSDTSTPE HHHHCCCCCCCCCHH	30.76	28102081
919	Phosphorylation	DFLGRSSSDTSTPEE HHHCCCCCCCCCHHH	46.27	28102081
921	Phosphorylation	LGRSSSDTSTPEELK HCCCCCCCCCHHHHE	36.13	28102081
922	Phosphorylation	GRSSSDTSTPEELKI CCCCCCCCCHHHHEE	47.13	28102081
923	Phosphorylation	RSSSDTSTPEELKIY CCCCCCCCHHHHEEE	36.49	21815630
930	Phosphorylation	TPEELKIYDSNLRIE CHHHHEEECCCCEEE	16.25	29978859
932	Phosphorylation	EELKIYDSNLRIEVK HHHEEECCCCEEEEE	22.31	29978859
944	Phosphorylation	EVKMKKQSNNDLFQV EEEEEECCCCCCEEE	46.62	-
955	Phosphorylation	LFQVNSTSDDEIPRK CEEECCCCCCCCCCC	42.77	28985074
1109	Phosphorylation	YSRFSRESEDNILEC HHCCCCCCCCCCEEH	49.49	27050516
1146	Phosphorylation	SSRKNKQSVSATEKK CCCCCCCCCCHHHCH	21.46	25072903
1148	Phosphorylation	RKNKQSVSATEKKNT CCCCCCCCHHHCHHH	34.42	25072903
1150	Phosphorylation	NKQSVSATEKKNTID CCCCCCHHHCHHHHH	40.61	25072903
1155	Phosphorylation	SATEKKNTIDVLSSR CHHHCHHHHHHHHHH	27.68	29083192
1160	Phosphorylation	KNTIDVLSSRSRQLL HHHHHHHHHHHHHHH	24.45	25072903
1161	Phosphorylation	NTIDVLSSRSRQLLR HHHHHHHHHHHHHHH	30.07	24719451
1163	Phosphorylation	IDVLSSRSRQLLRED HHHHHHHHHHHHHHC	26.73	29083192
1172	Ubiquitination	QLLREDKKVNNGSNV HHHHHCCCCCCCCCC	63.62	-
1196	Phosphorylation	FLDSDVKSQERPCHL HHCCCHHCCCCCCCC	36.80	29449344
1225	Phosphorylation	SSTKSLDSFRSQVLP CCCCCHHHHHHCCCC	28.05	22210691
1276	Phosphorylation	YDHRPSKTLSPIYEM CCCCCCCCCCCCEEC	36.48	28102081
1278	Phosphorylation	HRPSKTLSPIYEMDV CCCCCCCCCCEECHH	17.93	28348404
1281	Phosphorylation	SKTLSPIYEMDVIEA CCCCCCCEECHHHHH	14.48	28102081
1295	Phosphorylation	AFEQKVESETHVTDM HHHHHHHCCCCCCCC	51.27	28985074

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of K1107_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of K1107_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of K1107_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
AP3S1_HUMAN	AP3S1	physical	26496610
HSP7C_HUMAN	HSPA8	physical	26496610
TAF9_HUMAN	TAF9	physical	26496610
BAP1_HUMAN	BAP1	physical	26496610
NUMB_HUMAN	NUMB	physical	26496610
NUMBL_HUMAN	NUMBL	physical	26496610
BAZ2A_HUMAN	BAZ2A	physical	26496610
B4GT7_HUMAN	B4GALT7	physical	26496610
COBL1_HUMAN	COBLL1	physical	26496610
EFR3A_HUMAN	EFR3A	physical	26496610
MACF1_HUMAN	MACF1	physical	26496610
SK2L2_HUMAN	SKIV2L2	physical	26496610
IMPCT_HUMAN	IMPACT	physical	26496610
EP15R_HUMAN	EPS15L1	physical	26496610
RBM26_HUMAN	RBM26	physical	26496610
ZC3HE_HUMAN	ZC3H14	physical	26496610
WDR26_HUMAN	WDR26	physical	26496610
OBSCN_HUMAN	OBSCN	physical	26496610
LENG8_HUMAN	LENG8	physical	26496610
TAF8_HUMAN	TAF8	physical	26496610
LYSM2_HUMAN	LYSMD2	physical	26496610

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of K1107_HUMAN

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"ATM and ATR substrate analysis reveals extensive protein networksresponsive to DNA damage."; Matsuoka S., Ballif B.A., Smogorzewska A., McDonald E.R. III,Hurov K.E., Luo J., Bakalarski C.E., Zhao Z., Solimini N.,Lerenthal Y., Shiloh Y., Gygi S.P., Elledge S.J.; Science 316:1160-1166(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-891, AND MASSSPECTROMETRY.	17525332 [Abstract]