ITA9_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ITA9_HUMAN
• UniProt AC: Q13797
• Protein Name: Integrin alpha-9
• Gene Name: ITGA9
• Organism: Homo sapiens (Human).
• Sequence Length: 1035
• Subcellular Localization: Membrane ; Single-pass type I membrane protein .
• Protein Description: Integrin alpha-9/beta-1 (ITGA9:ITGB1) is a receptor for VCAM1, cytotactin and osteopontin. It recognizes the sequence A-E-I-D-G-I-E-L in cytotactin..
• Protein Sequence: MGGPAAPRGAGRLRALLLALVVAGIPAGAYNLDPQRPVHFQGPADSFFGYAVLEHFHDNTRWVLVGAPKADSKYSPSVKSPGAVFKCRVHTNPDRRCTELDMARGKNRGTSCGKTCREDRDDEWMGVSLARQPKADGRVLACAHRWKNIYYEADHILPHGFCYIIPSNLQAKGRTLIPCYEEYKKKYGEEHGSCQAGIAGFFTEELVVMGAPGSFYWAGTIKVLNLTDNTYLKLNDEVIMNRRYTYLGYAVTAGHFSHPSTIDVVGGAPQDKGIGKVYIFRADRRSGTLIKIFQASGKKMGSYFGSSLCAVDLNGDGLSDLLVGAPMFSEIRDEGQVTVYINRGNGALEEQLALTGDGAYNAHFGESIASLDDLDNDGFPDVAIGAPKEDDFAGAVYIYHGDAGGIVPQYSMKLSGQKINPVLRMFGQSISGGIDMDGNGYPDVTVGAFMSDSVVLLRARPVITVDVSIFLPGSINITAPQCHDGQQPVNCLNVTTCFSFHGKHVPGEIGLNYVLMADVAKKEKGQMPRVYFVLLGETMGQVTEKLQLTYMEETCRHYVAHVKRRVQDVISPIVFEAAYSLSEHVTGEEERELPPLTPVLRWKKGQKIAQKNQTVFERNCRSEDCAADLQLQGKLLLSSMDEKTLYLALGAVKNISLNISISNLGDDAYDANVSFNVSRELFFINMWQKEEMGISCELLESDFLKCSVGFPFMRSKSKYEFSVIFDTSHLSGEEEVLSFIVTAQSGNTERSESLHDNTLVLMVPLMHEVDTSITGIMSPTSFVYGESVDAANFIQLDDLECHFQPINITLQVYNTGPSTLPGSSVSISFPNRLSSGGAEMFHVQEMVVGQEKGNCSFQKNPTPCIIPQEQENIFHTIFAFFTKSGRKVLDCEKPGISCLTAHCNFSALAKEESRTIDIYMLLNTEILKKDSSSVIQFMSRAKVKVDPALRVVEIAHGNPEEVTVVFEALHNLEPRGYVVGWIIAISLLVGILIFLLLAVLLWKMGFFRRRYKEIIEAEKNRKENEDSWDWVQKNQ

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
73	Ubiquitination	GAPKADSKYSPSVKS ECCCCCCCCCCCCCC	50.74	-
73	Acetylation	GAPKADSKYSPSVKS ECCCCCCCCCCCCCC	50.74	20167786
175	Phosphorylation	NLQAKGRTLIPCYEE CCCCCCCEEEECHHH	37.39	26437602
180	Phosphorylation	GRTLIPCYEEYKKKY CCEEEECHHHHHHHH	13.36	26437602
183	Phosphorylation	LIPCYEEYKKKYGEE EEECHHHHHHHHCHH	19.03	26437602
225	N-linked_Glycosylation	AGTIKVLNLTDNTYL EEEEEEEECCCCCEE	43.83	19159218
319	Phosphorylation	DLNGDGLSDLLVGAP ECCCCCHHHHCCCCC	31.57	29759185
329	Phosphorylation	LVGAPMFSEIRDEGQ CCCCCCCEEECCCCE	26.34	29759185
429	Phosphorylation	VLRMFGQSISGGIDM HHHHHCCCCCCCCCC	21.07	23532336
453	Phosphorylation	VGAFMSDSVVLLRAR EEEECCCCEEEECCC	13.55	23532336
476	N-linked_Glycosylation	IFLPGSINITAPQCH EECCCCEEEECCCCC	27.53	UniProtKB CARBOHYD
493	N-linked_Glycosylation	QQPVNCLNVTTCFSF CCCCCEEEEEEEEEE	31.15	UniProtKB CARBOHYD
612	N-linked_Glycosylation	GQKIAQKNQTVFERN CHHHHHHCCHHHHCC	30.58	UniProtKB CARBOHYD
622	Phosphorylation	VFERNCRSEDCAADL HHHCCCCCHHHHHHH	39.73	-
638	Phosphorylation	LQGKLLLSSMDEKTL HCCEEHHHCCCHHHH	24.48	-
639	Phosphorylation	QGKLLLSSMDEKTLY CCEEHHHCCCHHHHH	30.17	-
654	N-linked_Glycosylation	LALGAVKNISLNISI HHHHHHHEEEEEEEE	23.60	UniProtKB CARBOHYD
658	N-linked_Glycosylation	AVKNISLNISISNLG HHHEEEEEEEEECCC	21.12	UniProtKB CARBOHYD
672	N-linked_Glycosylation	GDDAYDANVSFNVSR CCCCCCCCCEEECCH	27.37	UniProtKB CARBOHYD
676	N-linked_Glycosylation	YDANVSFNVSRELFF CCCCCEEECCHHHEE	24.29	UniProtKB CARBOHYD
707	Phosphorylation	ESDFLKCSVGFPFMR HCCCCCCCCCCCCCC	24.56	-
715	Phosphorylation	VGFPFMRSKSKYEFS CCCCCCCCCCEEEEE	29.50	-
807	N-linked_Glycosylation	ECHFQPINITLQVYN EEEEEEEEEEEEEEE	28.07	UniProtKB CARBOHYD
854	N-linked_Glycosylation	VVGQEKGNCSFQKNP ECCCCCCCCCCCCCC	29.36	UniProtKB CARBOHYD
904	N-linked_Glycosylation	SCLTAHCNFSALAKE EEEEECCCHHHHHCC	24.84	UniProtKB CARBOHYD
913	Phosphorylation	SALAKEESRTIDIYM HHHHCCHHCEEEEEE	35.50	-
915	Phosphorylation	LAKEESRTIDIYMLL HHCCHHCEEEEEEEE	32.08	-
938	Oxidation	SSSVIQFMSRAKVKV CCHHHHHHHHCCCCC	1.20	17322306
939	Phosphorylation	SSVIQFMSRAKVKVD CHHHHHHHHCCCCCC	30.30	24114839
1027	Phosphorylation	NRKENEDSWDWVQKN HHCCCCCCCHHHHHC	22.28	26657352
1033	Ubiquitination	DSWDWVQKNQ----- CCCHHHHHCC-----	47.93	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of ITA9_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ITA9_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ITA9_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
AL1A3_HUMAN	ALDH1A3	physical	28514442
NGAL_HUMAN	LCN2	physical	28514442
SPB4_HUMAN	SERPINB4	physical	28514442
SPR1B_HUMAN	SPRR1B	physical	28514442
ITB1_HUMAN	ITGB1	physical	28514442
PCYXL_HUMAN	PCYOX1L	physical	28514442
SMOC1_HUMAN	SMOC1	physical	28514442
IGLL5_HUMAN	IGLL5	physical	28514442
KLK10_HUMAN	KLK10	physical	28514442
INVO_HUMAN	IVL	physical	28514442
GRP78_HUMAN	HSPA5	physical	28514442
CALL5_HUMAN	CALML5	physical	28514442
EVPL_HUMAN	EVPL	physical	28514442
TBA4A_HUMAN	TUBA4A	physical	28514442

Drug and Disease Associations

• Kegg Disease
• H00590: Congenital muscular dystrophies (CMD/MDC), including: Merosin-deficient CMD (MDC1A); Ullrich CMD (UC
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

N-linked Glycosylation

"Glycoproteomics analysis of human liver tissue by combination ofmultiple enzyme digestion and hydrazide chemistry.";
Chen R., Jiang X., Sun D., Han G., Wang F., Ye M., Wang L., Zou H.;
J. Proteome Res. 8:651-661(2009).
Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-225, AND MASSSPECTROMETRY.
PubMed: 19159218