I12R1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: I12R1_HUMAN
• UniProt AC: P42701
• Protein Name: Interleukin-12 receptor subunit beta-1
• Gene Name: IL12RB1
• Organism: Homo sapiens (Human).
• Sequence Length: 662
• Subcellular Localization: Membrane; Single-pass type I membrane protein.
• Protein Description: Functions as an interleukin receptor which binds interleukin-12 with low affinity and is involved in IL12 transduction. Associated with IL12RB2 it forms a functional, high affinity receptor for IL12. Associates also with IL23R to form the interleukin-23 receptor which functions in IL23 signal transduction probably through activation of the Jak-Stat signaling cascade..
• Protein Sequence: MEPLVTWVVPLLFLFLLSRQGAACRTSECCFQDPPYPDADSGSASGPRDLRCYRISSDRYECSWQYEGPTAGVSHFLRCCLSSGRCCYFAAGSATRLQFSDQAGVSVLYTVTLWVESWARNQTEKSPEVTLQLYNSVKYEPPLGDIKVSKLAGQLRMEWETPDNQVGAEVQFRHRTPSSPWKLGDCGPQDDDTESCLCPLEMNVAQEFQLRRRQLGSQGSSWSKWSSPVCVPPENPPQPQVRFSVEQLGQDGRRRLTLKEQPTQLELPEGCQGLAPGTEVTYRLQLHMLSCPCKAKATRTLHLGKMPYLSGAAYNVAVISSNQFGPGLNQTWHIPADTHTEPVALNISVGTNGTTMYWPARAQSMTYCIEWQPVGQDGGLATCSLTAPQDPDPAGMATYSWSRESGAMGQEKCYYITIFASAHPEKLTLWSTVLSTYHFGGNASAAGTPHHVSVKNHSLDSVSVDWAPSLLSTCPGVLKEYVVRCRDEDSKQVSEHPVQPTETQVTLSGLRAGVAYTVQVRADTAWLRGVWSQPQRFSIEVQVSDWLIFFASLGSFLSILLVGVLGYLGLNRAARHLCPPLPTPCASSAIEFPGGKETWQWINPVDFQEEASLQEALVVEMSWDKGERTEPLEKTELPEGAPELALDTELSLEDGDRCKAKM

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
121	N-linked_Glycosylation	WVESWARNQTEKSPE HHHHHHCCCCCCCCC	45.43	UniProtKB CARBOHYD
244	Phosphorylation	PQPQVRFSVEQLGQD CCCCEEEEHHHCCCC	17.74	-
300	Phosphorylation	CKAKATRTLHLGKMP CCCEEEEEEECCCCC	17.74	-
329	N-linked_Glycosylation	NQFGPGLNQTWHIPA CCCCCCCCEEEECCC	43.05	UniProtKB CARBOHYD
346	N-linked_Glycosylation	HTEPVALNISVGTNG CCCCEEEEEEECCCC	18.10	UniProtKB CARBOHYD
352	N-linked_Glycosylation	LNISVGTNGTTMYWP EEEEECCCCCEEEEE	39.63	UniProtKB CARBOHYD
375 (in isoform 3)	Phosphorylation	-	26.92	-
442	N-linked_Glycosylation	STYHFGGNASAAGTP EEEECCCCCCCCCCC	30.97	UniProtKB CARBOHYD
456	N-linked_Glycosylation	PHHVSVKNHSLDSVS CCEEEECCCCCCEEC	28.02	UniProtKB CARBOHYD
508	Phosphorylation	TETQVTLSGLRAGVA CCEEEEECCCCCCEE	26.81	24719451

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of I12R1_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of I12R1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of I12R1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
IL23R_HUMAN	IL23R	physical	12023369
I12R2_HUMAN	IL12RB2	genetic	8943050
SMD3_HUMAN	SNRPD3	physical	21988832
TBB4A_HUMAN	TUBB4A	physical	26186194
TBB3_HUMAN	TUBB3	physical	26186194
TBB8_HUMAN	TUBB8	physical	26186194
GRP78_HUMAN	HSPA5	physical	26186194
TBA4A_HUMAN	TUBA4A	physical	26186194
TBA1A_HUMAN	TUBA1A	physical	26186194
CBWD1_HUMAN	CBWD1	physical	26186194
TXNIP_HUMAN	TXNIP	physical	26186194
LOXL2_HUMAN	LOXL2	physical	26186194
ISOC2_HUMAN	ISOC2	physical	26186194
RA51C_HUMAN	RAD51C	physical	26186194
CREL2_HUMAN	CRELD2	physical	26186194
TRM44_HUMAN	TRMT44	physical	26186194
TXNIP_HUMAN	TXNIP	physical	28514442
ISOC2_HUMAN	ISOC2	physical	28514442
TBA4A_HUMAN	TUBA4A	physical	28514442
TBB3_HUMAN	TUBB3	physical	28514442
LOXL2_HUMAN	LOXL2	physical	28514442
CBWD1_HUMAN	CBWD1	physical	28514442
NPTX1_HUMAN	NPTX1	physical	28514442
GRP78_HUMAN	HSPA5	physical	28514442
TBB8_HUMAN	TUBB8	physical	28514442
TRM44_HUMAN	TRMT44	physical	28514442
TBB4A_HUMAN	TUBB4A	physical	28514442

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.