dbPTM

IL23R_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	IL23R_HUMAN
UniProt AC	Q5VWK5
Protein Name	Interleukin-23 receptor
Gene Name	IL23R
Organism	Homo sapiens (Human).
Sequence Length	629
Subcellular Localization	Cell membrane Single-pass type I membrane protein .
Protein Description	Associates with IL12RB1 to form the interleukin-23 receptor. Binds IL23 and mediates T-cells, NK cells and possibly certain macrophage/myeloid cells stimulation probably through activation of the Jak-Stat signaling cascade. IL23 functions in innate and adaptive immunity and may participate in acute response to infection in peripheral tissues. IL23 may be responsible for autoimmune inflammatory diseases and be important for tumorigenesis..
Protein Sequence	MNQVTIQWDAVIALYILFSWCHGGITNINCSGHIWVEPATIFKMGMNISIYCQAAIKNCQPRKLHFYKNGIKERFQITRINKTTARLWYKNFLEPHASMYCTAECPKHFQETLICGKDISSGYPPDIPDEVTCVIYEYSGNMTCTWNAGKLTYIDTKYVVHVKSLETEEEQQYLTSSYINISTDSLQGGKKYLVWVQAANALGMEESKQLQIHLDDIVIPSAAVISRAETINATVPKTIIYWDSQTTIEKVSCEMRYKATTNQTWNVKEFDTNFTYVQQSEFYLEPNIKYVFQVRCQETGKRYWQPWSSLFFHKTPETVPQVTSKAFQHDTWNSGLTVASISTGHLTSDNRGDIGLLLGMIVFAVMLSILSLIGIFNRSFRTGIKRRILLLIPKWLYEDIPNMKNSNVVKMLQENSELMNNNSSEQVLYVDPMITEIKEIFIPEHKPTDYKKENTGPLETRDYPQNSLFDNTTVVYIPDLNTGYKPQISNFLPEGSHLSNNNEITSLTLKPPVDSLDSGNNPRLQKHPNFAFSVSSVNSLSNTIFLGELSLILNQGECSSPDIQNSVEEETTMLLENDSPSETIPEQTLLPDEFVSCLGIVNEELPSINTYFPQNILESHFNRISLLEK

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
29	N-linked_Glycosylation	HGGITNINCSGHIWV CCCCCCCCCCCEEEE	18.90	21053369
47	N-linked_Glycosylation	TIFKMGMNISIYCQA EEEECCCCEEEEEHH	21.08	21053369
51	Phosphorylation	MGMNISIYCQAAIKN CCCCEEEEEHHHHHH	3.32	22461510
81	N-linked_Glycosylation	RFQITRINKTTARLW HEEEEEECHHHHHHH	32.12	21053369
112	Phosphorylation	CPKHFQETLICGKDI CCHHHHCEEECCCCC	15.61	-
120	Phosphorylation	LICGKDISSGYPPDI EECCCCCCCCCCCCC	28.04	-
121	Phosphorylation	ICGKDISSGYPPDIP ECCCCCCCCCCCCCC	42.55	-
141	N-linked_Glycosylation	VIYEYSGNMTCTWNA EEEEECCCEEEEEEC	19.36	21053369
177	Phosphorylation	EQQYLTSSYINISTD HHHHHHHCEEEEEEC	25.46	-
178	Phosphorylation	QQYLTSSYINISTDS HHHHHHCEEEEEECC	9.58	-
180	N-linked_Glycosylation	YLTSSYINISTDSLQ HHHHCEEEEEECCCC	17.58	21053369
232	N-linked_Glycosylation	ISRAETINATVPKTI HCHHHHCCCCCCCEE	36.66	21053369
234	Phosphorylation	RAETINATVPKTIIY HHHHCCCCCCCEEEE	32.62	-
260	Phosphorylation	CEMRYKATTNQTWNV EEEEEEEECCCCEEE	23.33	29052541
261	Phosphorylation	EMRYKATTNQTWNVK EEEEEEECCCCEEEE	30.13	29052541
262	N-linked_Glycosylation	MRYKATTNQTWNVKE EEEEEECCCCEEEEE	32.69	21053369
264	Phosphorylation	YKATTNQTWNVKEFD EEEECCCCEEEEEEC	22.52	29052541
273	N-linked_Glycosylation	NVKEFDTNFTYVQQS EEEEECCCCEEEEEE	29.16	21053369
455	Phosphorylation	TDYKKENTGPLETRD CCCCCCCCCCCCCCC	41.07	22964224
460	Phosphorylation	ENTGPLETRDYPQNS CCCCCCCCCCCCCCC	36.20	22964224
506	Phosphorylation	SNNNEITSLTLKPPV CCCCCCEEEEECCCC	25.64	24719451
625	Phosphorylation	ESHFNRISLLEK--- HHHHHHHHHCCC---	24.54	24719451

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of IL23R_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of IL23R_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of IL23R_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
Oops, there are no PPI records of IL23R_HUMAN !!

Drug and Disease Associations

Kegg Disease
H00286	Crohn's disease
OMIM Disease
612261	Inflammatory bowel disease 17 (IBD17)
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of IL23R_HUMAN

Related Literatures of Post-Translational Modification

N-linked Glycosylation
Reference	PubMed
"Glycosylation analysis of interleukin-23 receptor: elucidation ofglycosylation sites and characterization of attached glycanstructures."; Zhao J., Liu Y.H., Reichert P., Pflanz S., Pramanik B.; J. Mass Spectrom. 45:1416-1425(2010). Cited for: GLYCOSYLATION AT ASN-29; ASN-47; ASN-81; ASN-141; ASN-180; ASN-232;ASN-262 AND ASN-273.	21053369 [Abstract]