| UniProt ID | FBW1B_MOUSE | |
|---|---|---|
| UniProt AC | Q5SRY7 | |
| Protein Name | F-box/WD repeat-containing protein 11 | |
| Gene Name | Fbxw11 | |
| Organism | Mus musculus (Mouse). | |
| Sequence Length | 542 | |
| Subcellular Localization | Cytoplasm . Nucleus . | |
| Protein Description | Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Probably recognizes and binds to phosphorylated target proteins. SCF(FBXW11) mediates the ubiquitination of phosphorylated CTNNB1 and participates in Wnt signaling. SCF(FBXW11) mediates the ubiquitination of phosphorylated NFKBIA, which degradation frees the associated NFKB1 to translocate into the nucleus and to activate transcription. SCF(FBXW11) mediates the ubiquitination of IFNAR1. SCF(FBXW11) mediates the ubiquitination of CEP68; this is required for centriole separation during mitosis (By similarity). Involved in the oxidative stress-induced a ubiquitin-mediated decrease in RCAN1. Mediates the degradation of CDC25A induced by ionizing radiation in cells progressing through S phase and thus may function in the intra-S-phase checkpoint. Has an essential role in the control of the clock-dependent transcription via degradation of phosphorylated PER1 and phosphorylated PER2. SCF(FBXW11) mediates the ubiquitination of CYTH1, and probably CYTH2 (By similarity).. | |
| Protein Sequence | MEPDSVIEDKTIELMCSVPRSLWLGCANLVESMCALSCLQSMPSVRCLQISNGTSSVIVSRKRPSEGNYQKEKDLCIKYFDQWSESDQVEFVEHLISRMCHYQHGHINSYLKPMLQRDFITALPEQGLDHIAENILSYLDARSLCAAELVCKEWQRVISEGMLWKKLIERMVRTDPLWKGLSERRGWDQYLFKNRPTDGPPNSFYRSLYPKIIQDIETIESNWRCGRHNLQRIQCRSENSKGVYCLQYDDDKIISGLRDNSIKIWDKSSLECLKVLTGHTGSVLCLQYDERVIVTGSSDSTVRVWDVNTGEVLNTLIHHNEAVLHLRFSNGLMVTCSKDRSIAVWDMASATDITLRRVLVGHRAAVNVVDFDDKYIVSASGDRTIKVWSTSTCEFVRTLNGHKRGIACLQYRDRLVVSGSSDNTIRLWDIECGACLRVLEGHEELVRCIRFDNKRIVSGAYDGKIKVWDLQAALDPRAPASTLCLRTLVEHSGRVFRLQFDEFQIISSSHDDTILIWDFLNVPPSAQNETRSPSRTYTYISR | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
|
|
||
* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 16 | S-palmitoylation | DKTIELMCSVPRSLW CCHHHHHHHCCCHHH | 6.07 | 28680068 | |
| 28 (in isoform 3) | Phosphorylation | - | 49.01 | 29899451 | |
| 65 | Phosphorylation | IVSRKRPSEGNYQKE EEECCCCCCCCCHHH | 63.27 | 26824392 | |
| 81 | Ubiquitination | DLCIKYFDQWSESDQ HEHHEECCCCCHHHH | 46.05 | 27667366 | |
| 86 | Phosphorylation | YFDQWSESDQVEFVE ECCCCCHHHHHHHHH | 28.03 | 24719451 | |
| 145 | Ubiquitination | YLDARSLCAAELVCK HHHHHHHHHHHHHHH | 3.39 | 27667366 | |
| 147 | Ubiquitination | DARSLCAAELVCKEW HHHHHHHHHHHHHHH | 15.06 | 27667366 | |
| 166 | Ubiquitination | SEGMLWKKLIERMVR HHCHHHHHHHHHHHH | 43.02 | 27667366 | |
| 168 | Ubiquitination | GMLWKKLIERMVRTD CHHHHHHHHHHHHHC | 4.30 | 27667366 | |
| 179 | Ubiquitination | VRTDPLWKGLSERRG HHHCCHHHHHHHHCC | 58.62 | 22790023 | |
| 179 (in isoform 2) | Ubiquitination | - | 58.62 | 22790023 | |
| 200 | Ubiquitination | KNRPTDGPPNSFYRS CCCCCCCCCCCHHHH | 27.92 | 27667366 | |
| 200 (in isoform 2) | Ubiquitination | - | 27.92 | - | |
| 252 | Acetylation | CLQYDDDKIISGLRD EEEECCCCEEECCCC | 49.27 | 23806337 | |
| 374 | Ubiquitination | NVVDFDDKYIVSASG EEEECCCCEEEECCC | 38.43 | 22790023 | |
| 374 (in isoform 2) | Ubiquitination | - | 38.43 | 22790023 | |
| 395 (in isoform 2) | Ubiquitination | - | 4.98 | - | |
| 534 | Phosphorylation | QNETRSPSRTYTYIS CCCCCCCCCCEEEEC | 38.20 | 29514104 | |
| 537 | Phosphorylation | TRSPSRTYTYISR-- CCCCCCCEEEECC-- | 9.09 | 29514104 | |
| 539 | Phosphorylation | SPSRTYTYISR---- CCCCCEEEECC---- | 6.10 | 29514104 | |
| 541 | Phosphorylation | SRTYTYISR------ CCCEEEECC------ | 22.86 | 22006019 | |
| 562 | Phosphorylation | --------------------------- --------------------------- | 24719451 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of FBW1B_MOUSE !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of FBW1B_MOUSE !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of FBW1B_MOUSE !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
| PER2_RAT | Per2 | physical | 18782782 | |
| APC_HUMAN | APC | physical | 26496610 | |
| RM49_HUMAN | MRPL49 | physical | 26496610 | |
| CO5A1_HUMAN | COL5A1 | physical | 26496610 | |
| CO5A2_HUMAN | COL5A2 | physical | 26496610 | |
| CTNA1_HUMAN | CTNNA1 | physical | 26496610 | |
| CTNB1_HUMAN | CTNNB1 | physical | 26496610 | |
| ROA2_HUMAN | HNRNPA2B1 | physical | 26496610 | |
| HNRPU_HUMAN | HNRNPU | physical | 26496610 | |
| ICT1_HUMAN | ICT1 | physical | 26496610 | |
| PLOD1_HUMAN | PLOD1 | physical | 26496610 | |
| SKP1_HUMAN | SKP1 | physical | 26496610 | |
| TFAP4_HUMAN | TFAP4 | physical | 26496610 | |
| PLOD3_HUMAN | PLOD3 | physical | 26496610 | |
| NOLC1_HUMAN | NOLC1 | physical | 26496610 | |
| MVP_HUMAN | MVP | physical | 26496610 | |
| HNRDL_HUMAN | HNRNPDL | physical | 26496610 | |
| SUN2_HUMAN | SUN2 | physical | 26496610 | |
| RM13_HUMAN | MRPL13 | physical | 26496610 | |
| GT251_HUMAN | COLGALT1 | physical | 26496610 | |
| SPIR2_HUMAN | SPIRE2 | physical | 26496610 |
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
loading...
