ECHD2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ECHD2_HUMAN
• UniProt AC: Q86YB7
• Protein Name: Enoyl-CoA hydratase domain-containing protein 2, mitochondrial
• Gene Name: ECHDC2
• Organism: Homo sapiens (Human).
• Sequence Length: 292
• Subcellular Localization: Mitochondrion .
• Protein Sequence: MLRVLCLLRPWRPLRARGCASDGAAGGSEIQVRALAGPDQGITEILMNRPSARNALGNVFVSELLETLAQLREDRQVRVLLFRSGVKGVFCAGADLKEREQMSEAEVGVFVQRLRGLMNDIAAFPAPTIAAMDGFALGGGLELALACDLRVAASSAVMGLIETTRGLLPGAGGTQRLPRCLGVALAKELIFTGRRLSGTEAHVLGLVNHAVAQNEEGDAAYQRARALAQEILPQAPIAVRLGKVAIDRGTEVDIASGMAIEGMCYAQNIPTRDRLEGMAAFREKRTPKFVGK

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
97	Acetylation	FCAGADLKEREQMSE EECCCCHHHHHHHCH	56.10	-
97	Succinylation	FCAGADLKEREQMSE EECCCCHHHHHHHCH	56.10	-
97	Succinylation	FCAGADLKEREQMSE EECCCCHHHHHHHCH	56.10	-
103	Phosphorylation	LKEREQMSEAEVGVF HHHHHHHCHHHHHHH	33.09	28509920
197	Phosphorylation	IFTGRRLSGTEAHVL HHCCCCCCCCHHHHH	41.69	20166139
199	Phosphorylation	TGRRLSGTEAHVLGL CCCCCCCCHHHHHHH	26.99	20166139

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of ECHD2_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ECHD2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ECHD2_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
A4_HUMAN	APP	physical	21832049
LSM8_HUMAN	LSM8	physical	21988832
AUHM_HUMAN	AUH	physical	26186194
SLIRP_HUMAN	SLIRP	physical	26186194
TOP3A_HUMAN	TOP3A	physical	26186194
UQCC1_HUMAN	UQCC1	physical	26186194
NDUS6_HUMAN	NDUFS6	physical	26186194
CAF17_HUMAN	IBA57	physical	26186194
CTU1_HUMAN	CTU1	physical	26186194
DNLZ_HUMAN	DNLZ	physical	26186194
AUHM_HUMAN	AUH	physical	28514442
NDUS6_HUMAN	NDUFS6	physical	28514442
HEM1_HUMAN	ALAS1	physical	28514442
DNLZ_HUMAN	DNLZ	physical	28514442
SLIRP_HUMAN	SLIRP	physical	28514442
MMAB_HUMAN	MMAB	physical	28514442
CTU1_HUMAN	CTU1	physical	28514442
TOP3A_HUMAN	TOP3A	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.