DAPP1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: DAPP1_HUMAN
• UniProt AC: Q9UN19
• Protein Name: Dual adapter for phosphotyrosine and 3-phosphotyrosine and 3-phosphoinositide
• Gene Name: DAPP1
• Organism: Homo sapiens (Human).
• Sequence Length: 280
• Subcellular Localization: Cytoplasm . Membrane ; Peripheral membrane protein . Membrane-associated after cell stimulation leading to its translocation.
• Protein Description: May act as a B-cell-associated adapter that regulates B-cell antigen receptor (BCR)-signaling downstream of PI3K..
• Protein Sequence: MGRAELLEGKMSTQDPSDLWSRSDGEAELLQDLGWYHGNLTRHAAEALLLSNGCDGSYLLRDSNETTGLYSLSVRAKDSVKHFHVEYTGYSFKFGFNEFSSLKDFVKHFANQPLIGSETGTLMVLKHPYPRKVEEPSIYESVRVHTAMQTGRTEDDLVPTAPSLGTKEGYLTKQGGLVKTWKTRWFTLHRNELKYFKDQMSPEPIRILDLTECSAVQFDYSQERVNCFCLVFPFRTFYLCAKTGVEADEWIKILRWKLSQIRKQLNQGEGTIRSRSFIFK

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
12	Phosphorylation	ELLEGKMSTQDPSDL HHHCCCCCCCCHHHH	26.80	25907765
13	Phosphorylation	LLEGKMSTQDPSDLW HHCCCCCCCCHHHHH	33.23	25907765
17	Phosphorylation	KMSTQDPSDLWSRSD CCCCCCHHHHHCCCC	54.33	25907765
73	Phosphorylation	TTGLYSLSVRAKDSV CCCEEEEEEEECCCC	12.01	24719451
100	Phosphorylation	KFGFNEFSSLKDFVK EECCCCCCCHHHHHH	28.69	28348404
101	Phosphorylation	FGFNEFSSLKDFVKH ECCCCCCCHHHHHHH	44.77	28348404
117	Phosphorylation	ANQPLIGSETGTLMV CCCCEECCCCCCEEE	25.62	28060719
119	Phosphorylation	QPLIGSETGTLMVLK CCEECCCCCCEEEEE	36.84	28060719
121	Phosphorylation	LIGSETGTLMVLKHP EECCCCCCEEEEECC	21.07	28060719
132	Ubiquitination	LKHPYPRKVEEPSIY EECCCCCCCCCCCHH	49.87	-
137	Phosphorylation	PRKVEEPSIYESVRV CCCCCCCCHHHHHHH	40.87	28796482
138	Phosphorylation	RKVEEPSIYESVRVH CCCCCCCHHHHHHHH	6.91	17016520
139	Phosphorylation	KVEEPSIYESVRVHT CCCCCCHHHHHHHHH	13.39	28176443
141	Phosphorylation	EEPSIYESVRVHTAM CCCCHHHHHHHHHHH	9.76	28796482
160	Phosphorylation	TEDDLVPTAPSLGTK CCCCCCCCCCCCCCC	43.66	29083192
163	Phosphorylation	DLVPTAPSLGTKEGY CCCCCCCCCCCCCEE	36.65	29083192
166	Phosphorylation	PTAPSLGTKEGYLTK CCCCCCCCCCEEEEC	31.08	29083192
167	Ubiquitination	TAPSLGTKEGYLTKQ CCCCCCCCCEEEECC	47.55	-
173	Ubiquitination	TKEGYLTKQGGLVKT CCCEEEECCCCEECE	44.33	-
180	Phosphorylation	KQGGLVKTWKTRWFT CCCCEECEEEEEEEE	25.39	24719451
182	Acetylation	GGLVKTWKTRWFTLH CCEECEEEEEEEEEE	33.18	20167786
195	Phosphorylation	LHRNELKYFKDQMSP EEHHHHHHHHHCCCC	28.61	23663014
201	Phosphorylation	KYFKDQMSPEPIRIL HHHHHCCCCCCEEEE	22.07	23663014
263	Ubiquitination	WKLSQIRKQLNQGEG HHHHHHHHHHHCCCC	61.85	-
271	Phosphorylation	QLNQGEGTIRSRSFI HHHCCCCCCCCCEEE	14.65	27535140
274	Phosphorylation	QGEGTIRSRSFIFK- CCCCCCCCCEEECC-	28.55	28176443
276	Phosphorylation	EGTIRSRSFIFK--- CCCCCCCEEECC---	24.76	25394399

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
139	Y	Phosphorylation	Kinase	LCK	P06239	PSP
139	Y	Phosphorylation	Kinase	LYN	P07948	PSP
139	Y	Phosphorylation	Kinase	SRC	P12931	PSP

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of DAPP1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of DAPP1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
RL23_HUMAN	RPL23	physical	21988832
FCSD2_HUMAN	FCHSD2	physical	21988832
3BHS7_HUMAN	HSD3B7	physical	21988832
GSTCD_HUMAN	GSTCD	physical	25814554
MYLIP_HUMAN	MYLIP	physical	25814554
WDR20_HUMAN	WDR20	physical	25814554
BACD2_HUMAN	TNFAIP1	physical	25814554
ZNHI1_HUMAN	ZNHIT1	physical	25814554
CNDP2_HUMAN	CNDP2	physical	25814554
HUMMR_HUMAN	MGARP	physical	25814554
RET7_HUMAN	RBP7	physical	25814554
T4S19_HUMAN	TM4SF19	physical	25814554
APBB3_HUMAN	APBB3	physical	25814554
PLAL2_HUMAN	PLAGL2	physical	25814554

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"An extensive survey of tyrosine phosphorylation revealing new sitesin human mammary epithelial cells.";
Heibeck T.H., Ding S.-J., Opresko L.K., Zhao R., Schepmoes A.A.,Yang F., Tolmachev A.V., Monroe M.E., Camp D.G. II, Smith R.D.,Wiley H.S., Qian W.-J.;
J. Proteome Res. 8:3852-3861(2009).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-139, AND MASSSPECTROMETRY.
PubMed: 19534553

"Multiple reaction monitoring for robust quantitative proteomicanalysis of cellular signaling networks.";
Wolf-Yadlin A., Hautaniemi S., Lauffenburger D.A., White F.M.;
Proc. Natl. Acad. Sci. U.S.A. 104:5860-5865(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-139, AND MASSSPECTROMETRY.
PubMed: 17389395

"Global survey of phosphotyrosine signaling identifies oncogenickinases in lung cancer.";
Rikova K., Guo A., Zeng Q., Possemato A., Yu J., Haack H., Nardone J.,Lee K., Reeves C., Li Y., Hu Y., Tan Z., Stokes M., Sullivan L.,Mitchell J., Wetzel R., Macneill J., Ren J.M., Yuan J.,Bakalarski C.E., Villen J., Kornhauser J.M., Smith B., Li D., Zhou X.,Gygi S.P., Gu T.-L., Polakiewicz R.D., Rush J., Comb M.J.;
Cell 131:1190-1203(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-139, AND MASSSPECTROMETRY.
PubMed: 18083107