PLAL2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: PLAL2_HUMAN
• UniProt AC: Q9UPG8
• Protein Name: Zinc finger protein PLAGL2
• Gene Name: PLAGL2
• Organism: Homo sapiens (Human).
• Sequence Length: 496
• Subcellular Localization: Nucleus .
• Protein Description: Shows weak transcriptional activatory activity..
• Protein Sequence: MTTFFTSVPPWIQDAKQEEEVGWKLVPRPRGREAESQVKCQCEISGTPFSNGEKLRPHSLPQPEQRPYSCPQLHCGKAFASKYKLYRHMATHSAQKPHQCMYCDKMFHRKDHLRNHLQTHDPNKEALHCSECGKNYNTKLGYRRHLAMHAASSGDLSCKVCLQTFESTQALLEHLKAHSRRVAGGAKEKKHPCDHCDRRFYTRKDVRRHLVVHTGRKDFLCQYCAQRFGRKDHLTRHVKKSHSQELLKIKTEPVDMLGLLSCSSTVSVKEELSPVLCMASRDVMGTKAFPGMLPMGMYGAHIPTMPSTGVPHSLVHNTLPMGMSYPLESSPISSPAQLPPKYQLGSTSYLPDKLPKVEVDSFLAELPGSLSLSSAEPQPASPQPAAAAALLDEALLAKSPANLSEALCAANVDFSHLLGFLPLNLPPCNPPGATGGLVMGYSQAEAQPLLTTLQAQPQDSPGAGGPLNFGPLHSLPPVFTSGLSSTTLPRFHQAFQ

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
16	Acetylation	PPWIQDAKQEEEVGW CCCHHCCHHHHHHCC	67.54	25953088
24	Ubiquitination	QEEEVGWKLVPRPRG HHHHHCCEEEECCCC	33.41	29967540
82	Acetylation	CGKAFASKYKLYRHM CCHHHHHHHHHHHHH	42.87	25953088
96	Acetylation	MATHSAQKPHQCMYC HHHHCCCCCHHCCCC	44.15	25953088
139	Ubiquitination	CGKNYNTKLGYRRHL CCCCCCCCHHHHHHH	35.96	-
240	Ubiquitination	HLTRHVKKSHSQELL HHHHHHHHHHHHHHH	52.92	29967540
241	Phosphorylation	LTRHVKKSHSQELLK HHHHHHHHHHHHHHH	23.74	30001349
243	Phosphorylation	RHVKKSHSQELLKIK HHHHHHHHHHHHHCC	32.23	25159151
248	Ubiquitination	SHSQELLKIKTEPVD HHHHHHHHCCCCCCC	55.57	-
248	Acetylation	SHSQELLKIKTEPVD HHHHHHHHCCCCCCC	55.57	20167786
250	Sumoylation	SQELLKIKTEPVDML HHHHHHCCCCCCCHH	45.29	-
250	Sumoylation	SQELLKIKTEPVDML HHHHHHCCCCCCCHH	45.29	-
250	Acetylation	SQELLKIKTEPVDML HHHHHHCCCCCCCHH	45.29	17551969
251	Phosphorylation	QELLKIKTEPVDMLG HHHHHCCCCCCCHHH	49.33	-
263	Phosphorylation	MLGLLSCSSTVSVKE HHHHCCCCCCCCCCH	26.18	26437602
265	Phosphorylation	GLLSCSSTVSVKEEL HHCCCCCCCCCCHHH	10.66	-
267	Phosphorylation	LSCSSTVSVKEELSP CCCCCCCCCCHHHHH	27.79	26437602
269	Sumoylation	CSSTVSVKEELSPVL CCCCCCCCHHHHHHH	37.65	-
269	Sumoylation	CSSTVSVKEELSPVL CCCCCCCCHHHHHHH	37.65	-
269	Acetylation	CSSTVSVKEELSPVL CCCCCCCCHHHHHHH	37.65	17551969
273	Phosphorylation	VSVKEELSPVLCMAS CCCCHHHHHHHHHHC	19.08	23401153
280	Phosphorylation	SPVLCMASRDVMGTK HHHHHHHCCCCCCCC	11.35	26074081
286	Phosphorylation	ASRDVMGTKAFPGML HCCCCCCCCCCCCCC	10.91	22210691
342	Phosphorylation	PAQLPPKYQLGSTSY CCCCCCCCCCCCCCC	18.10	23186163
346	Phosphorylation	PPKYQLGSTSYLPDK CCCCCCCCCCCCCCC	23.83	23186163
349	Phosphorylation	YQLGSTSYLPDKLPK CCCCCCCCCCCCCCC	23.49	28555341
353	Ubiquitination	STSYLPDKLPKVEVD CCCCCCCCCCCCCHH	65.82	29967540
356	Sumoylation	YLPDKLPKVEVDSFL CCCCCCCCCCHHHHH	62.56	-
356	Acetylation	YLPDKLPKVEVDSFL CCCCCCCCCCHHHHH	62.56	17551969
356	Sumoylation	YLPDKLPKVEVDSFL CCCCCCCCCCHHHHH	62.56	-
369	Phosphorylation	FLAELPGSLSLSSAE HHHHCCCCCCCCCCC	16.91	29523821
371	Phosphorylation	AELPGSLSLSSAEPQ HHCCCCCCCCCCCCC	28.09	29523821
373	Phosphorylation	LPGSLSLSSAEPQPA CCCCCCCCCCCCCCC	24.91	29523821
374	Phosphorylation	PGSLSLSSAEPQPAS CCCCCCCCCCCCCCC	41.78	29523821
381	Phosphorylation	SAEPQPASPQPAAAA CCCCCCCCCCHHHHH	30.65	25159151

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of PLAL2_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of PLAL2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of PLAL2_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
KAT5_HUMAN	KAT5	physical	17551969

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.