COLI_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: COLI_HUMAN
• UniProt AC: P01189
• Protein Name: Pro-opiomelanocortin
• Gene Name: POMC
• Organism: Homo sapiens (Human).
• Sequence Length: 267
• Subcellular Localization: Secreted . Melanocyte-stimulating hormone alpha and beta-endorphin are stored in separate granules in hypothalamic POMC neurons, suggesting that secretion may be under the control of different regulatory mechanisms.
• Protein Description: Corticotropin: Stimulates the adrenal glands to release cortisol.; Melanocyte-stimulating hormone alpha: Anorexigenic peptide. Increases the pigmentation of skin by increasing melanin production in melanocytes.; Melanocyte-stimulating hormone beta: Increases the pigmentation of skin by increasing melanin production in melanocytes.; Beta-endorphin: Endogenous orexigenic opiate.; Met-enkephalin: Endogenous opiate..
• Protein Sequence: MPRSCCSRSGALLLALLLQASMEVRGWCLESSQCQDLTTESNLLECIRACKPDLSAETPMFPGNGDEQPLTENPRKYVMGHFRWDRFGRRNSSSSGSSGAGQKREDVSAGEDCGPLPEGGPEPRSDGAKPGPREGKRSYSMEHFRWGKPVGKKRRPVKVYPNGAEDESAEAFPLEFKRELTGQRLREGDGPDGPADDGAGAQADLEHSLLVAAEKKDEGPYRMEHFRWGSPPKDKRYGGFMTSEKSQTPLVTLFKNAIIKNAYKKGE

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
55	Phosphorylation	RACKPDLSAETPMFP HHHCCCCCCCCCCCC	31.29	29691806
58	Phosphorylation	KPDLSAETPMFPGNG CCCCCCCCCCCCCCC	21.55	29691806
71	O-linked_Glycosylation	NGDEQPLTENPRKYV CCCCCCCCCCCCHHH	40.16	6267033
87	Phenylalanine amide	GHFRWDRFGRRNSSS EEECCCCCCCCCCCC	9.17	-
87	Amidation	GHFRWDRFGRRNSSS EEECCCCCCCCCCCC	9.17	-
91	N-linked_Glycosylation	WDRFGRRNSSSSGSS CCCCCCCCCCCCCCC	44.90	6945581
92	Phosphorylation	DRFGRRNSSSSGSSG CCCCCCCCCCCCCCC	29.77	-
95	Phosphorylation	GRRNSSSSGSSGAGQ CCCCCCCCCCCCCCC	44.64	-
97	Phosphorylation	RNSSSSGSSGAGQKR CCCCCCCCCCCCCCC	27.78	-
108	Phosphorylation	GQKREDVSAGEDCGP CCCCCCCCCCCCCCC	42.76	29691806
125	Phosphorylation	EGGPEPRSDGAKPGP CCCCCCCCCCCCCCC	51.62	29691806
134	Amidation	GAKPGPREGKRSYSM CCCCCCCCCCCCCCC	72.67	6272808
134	Glutamic acid 1-amide	GAKPGPREGKRSYSM CCCCCCCCCCCCCCC	72.67	-
138	Phosphorylation	GPREGKRSYSMEHFR CCCCCCCCCCCCCCC	25.66	29691806
138	Acetylation	GPREGKRSYSMEHFR CCCCCCCCCCCCCCC	25.66	-
140	Phosphorylation	REGKRSYSMEHFRWG CCCCCCCCCCCCCCC	20.95	29691806
150	Valine amide	HFRWGKPVGKKRRPV CCCCCCCCCCCCCCE	23.34	-
150	Amidation	HFRWGKPVGKKRRPV CCCCCCCCCCCCCCE	23.34	-
168	Phosphorylation	PNGAEDESAEAFPLE CCCCCCCCCCCCCCH	43.67	29691806
230	Phosphorylation	MEHFRWGSPPKDKRY CCCCCCCCCCCCCCC	30.94	27251275

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of COLI_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of COLI_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of COLI_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
MC4R_HUMAN	MC4R	physical	11101306
MC4R_HUMAN	MC4R	physical	9058374
MC5R_HUMAN	MC5R	physical	9058374
MC3R_HUMAN	MC3R	physical	9058374
MSHR_HUMAN	MC1R	physical	9058374
A4_HUMAN	APP	physical	21832049
TTL_HUMAN	TTL	physical	28514442
E2F4_HUMAN	E2F4	physical	28514442
UBR4_HUMAN	UBR4	physical	28514442
KLH15_HUMAN	KLHL15	physical	28514442
DCAM_HUMAN	AMD1	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• 601665: Obesity (OBESITY)
• 609734: Pro-opiomelanocortinin deficiency (POMCD)
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Amidation

"Alpha-amidated peptides derived from pro-opiomelanocortin in normalhuman pituitary.";
Fenger M., Johnsen A.H.;
Biochem. J. 250:781-788(1988).
Cited for: PROTEOLYTIC PROCESSING.
PubMed: 2839146

O-linked Glycosylation

"Primary structure of the major human pituitary pro-opiomelanocortinNH2-terminal glycopeptide. Evidence for an aldosterone-stimulatingactivity.";
Seidah N.G., Rochemont J., Hamelin J., Lis M., Chretien M.;
J. Biol. Chem. 256:7977-7984(1981).
Cited for: PROTEIN SEQUENCE OF 27-102.
PubMed: 6267033

Phosphorylation

"Phosphoproteomic analysis of the human pituitary.";
Beranova-Giorgianni S., Zhao Y., Desiderio D.M., Giorgianni F.;
Pituitary 9:109-120(2006).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-168, AND MASSSPECTROMETRY.
PubMed: 16807684