MC3R_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: MC3R_HUMAN
• UniProt AC: P41968
• Protein Name: Melanocortin receptor 3
• Gene Name: MC3R
• Organism: Homo sapiens (Human).
• Sequence Length: 323
• Subcellular Localization: Cell membrane; Multi-pass membrane protein.
• Protein Description: Receptor for MSH (alpha, beta and gamma) and ACTH. This receptor is mediated by G proteins which activate adenylate cyclase. Required for expression of anticipatory patterns of activity and wakefulness during periods of limited nutrient availability and for the normal regulation of circadian clock activity in the brain..
• Protein Sequence: MNASCCLPSVQPTLPNGSEHLQAPFFSNQSSSAFCEQVFIKPEVFLSLGIVSLLENILVILAVVRNGNLHSPMYFFLCSLAVADMLVSVSNALETIMIAIVHSDYLTFEDQFIQHMDNIFDSMICISLVASICNLLAIAVDRYVTIFYALRYHSIMTVRKALTLIVAIWVCCGVCGVVFIVYSESKMVIVCLITMFFAMMLLMGTLYVHMFLFARLHVKRIAALPPADGVAPQQHSCMKGAVTITILLGVFIFCWAPFFLHLVLIITCPTNPYCICYTAHFNTYLVLIMCNSVIDPLIYAFRSLELRNTFREILCGCNGMNLG

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	N-linked_Glycosylation	------MNASCCLPS ------CCCCCCCCC	40.33	UniProtKB CARBOHYD
4	Phosphorylation	----MNASCCLPSVQ ----CCCCCCCCCCC	10.60	24043423
9	Phosphorylation	NASCCLPSVQPTLPN CCCCCCCCCCCCCCC	22.04	24043423
13	Phosphorylation	CLPSVQPTLPNGSEH CCCCCCCCCCCCCCC	37.44	24043423
16	N-linked_Glycosylation	SVQPTLPNGSEHLQA CCCCCCCCCCCCCCC	70.50	UniProtKB CARBOHYD
18	Phosphorylation	QPTLPNGSEHLQAPF CCCCCCCCCCCCCCC	28.60	24043423
27	Phosphorylation	HLQAPFFSNQSSSAF CCCCCCCCCCCCCHH	34.05	24043423
28	N-linked_Glycosylation	LQAPFFSNQSSSAFC CCCCCCCCCCCCHHH	40.37	UniProtKB CARBOHYD
30	Phosphorylation	APFFSNQSSSAFCEQ CCCCCCCCCCHHHHH	30.43	24043423
31	Phosphorylation	PFFSNQSSSAFCEQV CCCCCCCCCHHHHHH	18.87	24043423
32	Phosphorylation	FFSNQSSSAFCEQVF CCCCCCCCHHHHHHC	30.52	24043423
145	Phosphorylation	IAVDRYVTIFYALRY HHHHHHHHHHHHHHH	9.09	-
303	Phosphorylation	PLIYAFRSLELRNTF HHHHHHHCHHHHHHH	21.53	24719451
315	S-palmitoylation	NTFREILCGCNGMNL HHHHHHHHCCCCCCC	7.78	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of MC3R_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of MC3R_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of MC3R_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of MC3R_HUMAN !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.