| UniProt ID | MC5R_HUMAN | |
|---|---|---|
| UniProt AC | P33032 | |
| Protein Name | Melanocortin receptor 5 | |
| Gene Name | MC5R | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 325 | |
| Subcellular Localization |
Cell membrane Multi-pass membrane protein. |
|
| Protein Description | Receptor for MSH (alpha, beta and gamma) and ACTH. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. This receptor is a possible mediator of the immunomodulation properties of melanocortins.. | |
| Protein Sequence | MNSSFHLHFLDLNLNATEGNLSGPNVKNKSSPCEDMGIAVEVFLTLGVISLLENILVIGAIVKNKNLHSPMYFFVCSLAVADMLVSMSSAWETITIYLLNNKHLVIADAFVRHIDNVFDSMICISVVASMCSLLAIAVDRYVTIFYALRYHHIMTARRSGAIIAGIWAFCTGCGIVFILYSESTYVILCLISMFFAMLFLLVSLYIHMFLLARTHVKRIAALPGASSARQRTSMQGAVTVTMLLGVFTVCWAPFFLHLTLMLSCPQNLYCSRFMSHFNMYLILIMCNSVMDPLIYAFRSQEMRKTFKEIICCRGFRIACSFPRRD | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 2 | N-linked_Glycosylation | ------MNSSFHLHF ------CCCCEEEEE | 46.49 | UniProtKB CARBOHYD | |
| 15 | N-linked_Glycosylation | HFLDLNLNATEGNLS EEEECCCCCCCCCCC | 43.68 | UniProtKB CARBOHYD | |
| 20 | N-linked_Glycosylation | NLNATEGNLSGPNVK CCCCCCCCCCCCCCC | 25.46 | UniProtKB CARBOHYD | |
| 28 | N-linked_Glycosylation | LSGPNVKNKSSPCED CCCCCCCCCCCCCHH | 45.20 | UniProtKB CARBOHYD | |
| 143 | Phosphorylation | IAVDRYVTIFYALRY HHHHHHHHHHHHHHH | 9.09 | - | |
| 150 | Phosphorylation | TIFYALRYHHIMTAR HHHHHHHHHHHHHCH | 9.90 | - | |
| 155 | Phosphorylation | LRYHHIMTARRSGAI HHHHHHHHCHHCCCH | 19.19 | - | |
| 311 | S-palmitoylation | KTFKEIICCRGFRIA HHHHHHHHCCCCEEE | 1.27 | - | |
| 312 | S-palmitoylation | TFKEIICCRGFRIAC HHHHHHHCCCCEEEE | 3.16 | - |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of MC5R_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of MC5R_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of MC5R_HUMAN !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
Oops, there are no PPI records of MC5R_HUMAN !! | ||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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