CNBP1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CNBP1_HUMAN
• UniProt AC: Q9NSA3
• Protein Name: Beta-catenin-interacting protein 1
• Gene Name: CTNNBIP1
• Organism: Homo sapiens (Human).
• Sequence Length: 81
• Subcellular Localization: Cytoplasm. Nucleus.
• Protein Description: Prevents the interaction between CTNNB1 and TCF family members, and acts as negative regulator of the Wnt signaling pathway..
• Protein Sequence: MNREGAPGKSPEEMYIQQKVRVLLMLRKMGSNLTASEEEFLRTYAGVVNSQLSQLPPHSIDQGAEDVVMAFSRSETEDRRQ

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
9	Ubiquitination	NREGAPGKSPEEMYI CCCCCCCCCHHHHHH	62.87	-
10	Phosphorylation	REGAPGKSPEEMYIQ CCCCCCCCHHHHHHH	43.38	25159151
15	Phosphorylation	GKSPEEMYIQQKVRV CCCHHHHHHHHHHHH	10.00	26091039
19	Ubiquitination	EEMYIQQKVRVLLML HHHHHHHHHHHHHHH	18.68	21890473
19	Ubiquitination	EEMYIQQKVRVLLML HHHHHHHHHHHHHHH	18.68	21890473
25	Sulfoxidation	QKVRVLLMLRKMGSN HHHHHHHHHHHHCCC	2.73	21406390
28	Ubiquitination	RVLLMLRKMGSNLTA HHHHHHHHHCCCCCC	43.59	21890473
31	Phosphorylation	LMLRKMGSNLTASEE HHHHHHCCCCCCCHH	25.76	28348404
34	Phosphorylation	RKMGSNLTASEEEFL HHHCCCCCCCHHHHH	32.18	27251275
36	Phosphorylation	MGSNLTASEEEFLRT HCCCCCCCHHHHHHH	40.06	27251275
59	Phosphorylation	LSQLPPHSIDQGAED HHCCCCCCCCCCCHH	33.36	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of CNBP1_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CNBP1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CNBP1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
BEND5_HUMAN	BEND5	physical	16189514
CTNB1_HUMAN	CTNNB1	physical	17353931
BGAL_HUMAN	GLB1	physical	17353931
PLAK_HUMAN	JUP	physical	17353931
CPVL_HUMAN	CPVL	physical	17353931
PNMA2_HUMAN	PNMA2	physical	17353931
PPGB_HUMAN	CTSA	physical	17353931
AATM_HUMAN	GOT2	physical	17353931
RFA3_HUMAN	RPA3	physical	17353931
2AAA_HUMAN	PPP2R1A	physical	17353931
CTNB1_HUMAN	CTNNB1	physical	10898789
USBP1_HUMAN	USHBP1	physical	25416956
KR107_HUMAN	KRTAP10-7	physical	25416956
KR103_HUMAN	KRTAP10-3	physical	25416956
INCA1_HUMAN	INCA1	physical	25416956
CTNB1_MOUSE	Ctnnb1	physical	12408825
CTNB1_HUMAN	CTNNB1	physical	12408825
KITM_HUMAN	TK2	physical	28514442
APC_HUMAN	APC	physical	28514442
PMGE_HUMAN	BPGM	physical	28514442
CTNA2_HUMAN	CTNNA2	physical	28514442
CTNB1_HUMAN	CTNNB1	physical	28514442
PNMA2_HUMAN	PNMA2	physical	28514442
CTNA1_HUMAN	CTNNA1	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.