ARL4C_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ARL4C_HUMAN
• UniProt AC: P56559
• Protein Name: ADP-ribosylation factor-like protein 4C
• Gene Name: ARL4C
• Organism: Homo sapiens (Human).
• Sequence Length: 192
• Subcellular Localization: Cell projection, filopodium. Cell membrane. Cytoplasm.
• Protein Description: Small GTP-binding protein which cycles between an inactive GDP-bound and an active GTP-bound form, and the rate of cycling is regulated by guanine nucleotide exchange factors (GEF) and GTPase-activating proteins (GAP). GTP-binding protein that does not act as an allosteric activator of the cholera toxin catalytic subunit. May be involved in transport between a perinuclear compartment and the plasma membrane, apparently linked to the ABCA1-mediated cholesterol secretion pathway. Recruits CYTH1, CYTH2, CYTH3 and CYTH4 to the plasma membrane in the GDP-bound form. Regulates the microtubule-dependent intracellular vesicular transport from early endosome to recycling endosome process..
• Protein Sequence: MGNISSNISAFQSLHIVMLGLDSAGKTTVLYRLKFNEFVNTVPTIGFNTEKIKLSNGTAKGISCHFWDVGGQEKLRPLWKSYSRCTDGIIYVVDSVDVDRLEEAKTELHKVTKFAENQGTPLLVIANKQDLPKSLPVAEIEKQLALHELIPATTYHVQPACAIIGEGLTEGMDKLYEMILKRRKSLKQKKKR

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Myristoylation	------MGNISSNIS ------CCCCHHHHH	39.93	-
9	Phosphorylation	GNISSNISAFQSLHI CCCHHHHHHHHHHEE	27.55	24719451
31	Phosphorylation	AGKTTVLYRLKFNEF CCCEEEEEEEEHHHH	15.01	24719451
51	Ubiquitination	TIGFNTEKIKLSNGT CCCCCCCEEEECCCC	43.00	-
53	Ubiquitination	GFNTEKIKLSNGTAK CCCCCEEEECCCCCC	57.86	-
60	Ubiquitination	KLSNGTAKGISCHFW EECCCCCCEEEEEEE	57.52	-
74	Ubiquitination	WDVGGQEKLRPLWKS EECCCCCCCHHHHHH	41.74	-
80	Ubiquitination	EKLRPLWKSYSRCTD CCCHHHHHHHHCCCC	47.39	-
80	Ubiquitination	EKLRPLWKSYSRCTD CCCHHHHHHHHCCCC	47.39	-
106	Phosphorylation	DRLEEAKTELHKVTK HHHHHHHHHHHHHHH	51.32	23403867
110	Ubiquitination	EAKTELHKVTKFAEN HHHHHHHHHHHHHHH	65.31	-
113	Ubiquitination	TELHKVTKFAENQGT HHHHHHHHHHHHCCC	45.63	21906983
113	Ubiquitination	TELHKVTKFAENQGT HHHHHHHHHHHHCCC	45.63	-
128	Ubiquitination	PLLVIANKQDLPKSL CEEEEEECCCCCCCC	35.85	-
133	Ubiquitination	ANKQDLPKSLPVAEI EECCCCCCCCCHHHH	72.43	-
133	Ubiquitination	ANKQDLPKSLPVAEI EECCCCCCCCCHHHH	72.43	-
181	Ubiquitination	KLYEMILKRRKSLKQ HHHHHHHHHHHHHHH	38.95	2189047
181	Ubiquitination	KLYEMILKRRKSLKQ HHHHHHHHHHHHHHH	38.95	-
185	Phosphorylation	MILKRRKSLKQKKKR HHHHHHHHHHHHHCC	38.70	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of ARL4C_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ARL4C_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ARL4C_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
A4_HUMAN	APP	physical	21832049
XRCC2_HUMAN	XRCC2	physical	28514442
RGS12_HUMAN	RGS12	physical	28514442
FBX33_HUMAN	FBXO33	physical	28514442
DIRA1_HUMAN	DIRAS1	physical	28514442
TERF2_HUMAN	TERF2	physical	28514442
RA51B_HUMAN	RAD51B	physical	28514442
KBRS1_HUMAN	NKIRAS1	physical	28514442
DJC12_HUMAN	DNAJC12	physical	28514442
DPOE2_HUMAN	POLE2	physical	28514442
TE2IP_HUMAN	TERF2IP	physical	28514442
RA51D_HUMAN	RAD51D	physical	28514442
ARL10_HUMAN	ARL10	physical	28514442
DPOE4_HUMAN	POLE4	physical	28514442
PAF1_HUMAN	PAF1	physical	28514442
GAB1_HUMAN	GAB1	physical	28514442
OAF_HUMAN	OAF	physical	28514442
ARF5_HUMAN	ARF5	physical	28514442
GDS1_HUMAN	RAP1GDS1	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.