STXB6_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: STXB6_HUMAN
• UniProt AC: Q8NFX7
• Protein Name: Syntaxin-binding protein 6
• Gene Name: STXBP6
• Organism: Homo sapiens (Human).
• Sequence Length: 210
• Subcellular Localization: Cytoplasm . Membrane ; Peripheral membrane protein .
• Protein Description: Forms non-fusogenic complexes with SNAP25 and STX1A and may thereby modulate the formation of functional SNARE complexes and exocytosis..
• Protein Sequence: MSAKSAISKEIFAPLDERMLGAVQVKRRTKKKIPFLATGGQGEYLTYICLSVTNKKPTQASITKVKQFEGSTSFVRRSQWMLEQLRQVNGIDPNGDSAEFDLLFENAFDQWVASTASEKCTFFQILHHTCQRYLTDRKPEFINCQSKIMGGNSILHSAADSVTSAVQKASQALNERGERLGRAEEKTEDLKNSAQQFAETAHKLAMKHKC

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MSAKSAISK ------CCHHHHHHH	44.39	22814378
8	Phosphorylation	MSAKSAISKEIFAPL CCHHHHHHHHHCCCC	24.77	24076635
9	Ubiquitination	SAKSAISKEIFAPLD CHHHHHHHHHCCCCC	49.03	30230243
21	Ubiquitination	PLDERMLGAVQVKRR CCCHHHCCCHHCCCC	17.85	30230243
26	Ubiquitination	MLGAVQVKRRTKKKI HCCCHHCCCCCCCCC	21.04	30230243
38	Ubiquitination	KKIPFLATGGQGEYL CCCCEEEECCCCCEE	43.95	30230243
56	Ubiquitination	CLSVTNKKPTQASIT EEEECCCCCCCCCEE	56.20	30230243
63	O-linked_Glycosylation	KPTQASITKVKQFEG CCCCCCEEEEEEECC	27.56	30059200
64	Ubiquitination	PTQASITKVKQFEGS CCCCCEEEEEEECCC	45.85	30230243
66	Ubiquitination	QASITKVKQFEGSTS CCCEEEEEEECCCCH	51.31	30230243
68	Ubiquitination	SITKVKQFEGSTSFV CEEEEEEECCCCHHH	10.73	30230243
76	Ubiquitination	EGSTSFVRRSQWMLE CCCCHHHHHHHHHHH	30.44	30230243
78	Ubiquitination	STSFVRRSQWMLEQL CCHHHHHHHHHHHHH	20.03	30230243
78	Phosphorylation	STSFVRRSQWMLEQL CCHHHHHHHHHHHHH	20.03	24076635
146	Phosphorylation	PEFINCQSKIMGGNS HHHHCCCCHHCCCCH	26.75	-
147	Malonylation	EFINCQSKIMGGNSI HHHCCCCHHCCCCHH	15.72	26320211
153	Phosphorylation	SKIMGGNSILHSAAD CHHCCCCHHHHHHHH	29.78	27251275
157	Phosphorylation	GGNSILHSAADSVTS CCCHHHHHHHHHHHH	23.00	-
161	Phosphorylation	ILHSAADSVTSAVQK HHHHHHHHHHHHHHH	23.67	-
191	Ubiquitination	EEKTEDLKNSAQQFA HHHHHHHHHHHHHHH	62.27	29967540

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of STXB6_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of STXB6_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of STXB6_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
ALS2_HUMAN	ALS2	physical	28514442
STX7_HUMAN	STX7	physical	28514442
STX1A_HUMAN	STX1A	physical	28514442
STX3_HUMAN	STX3	physical	28514442
STX4_HUMAN	STX4	physical	28514442
SNAG_HUMAN	NAPG	physical	28514442
STX8_HUMAN	STX8	physical	28514442
VTI1B_HUMAN	VTI1B	physical	28514442
STX12_HUMAN	STX12	physical	28514442
ATG7_HUMAN	ATG7	physical	28514442
STX6_HUMAN	STX6	physical	28514442
SNAA_HUMAN	NAPA	physical	28514442
SNP23_HUMAN	SNAP23	physical	28514442

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.