UniProt ID | STXB6_HUMAN | |
---|---|---|
UniProt AC | Q8NFX7 | |
Protein Name | Syntaxin-binding protein 6 | |
Gene Name | STXBP6 | |
Organism | Homo sapiens (Human). | |
Sequence Length | 210 | |
Subcellular Localization |
Cytoplasm . Membrane Peripheral membrane protein . |
|
Protein Description | Forms non-fusogenic complexes with SNAP25 and STX1A and may thereby modulate the formation of functional SNARE complexes and exocytosis.. | |
Protein Sequence | MSAKSAISKEIFAPLDERMLGAVQVKRRTKKKIPFLATGGQGEYLTYICLSVTNKKPTQASITKVKQFEGSTSFVRRSQWMLEQLRQVNGIDPNGDSAEFDLLFENAFDQWVASTASEKCTFFQILHHTCQRYLTDRKPEFINCQSKIMGGNSILHSAADSVTSAVQKASQALNERGERLGRAEEKTEDLKNSAQQFAETAHKLAMKHKC | |
Overview of Protein Modification Sites with Functional and Structural Information | ||
* ASA = Accessible Surface Area
Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
---|---|---|---|---|---|
2 | Acetylation | ------MSAKSAISK ------CCHHHHHHH | 44.39 | 22814378 | |
8 | Phosphorylation | MSAKSAISKEIFAPL CCHHHHHHHHHCCCC | 24.77 | 24076635 | |
9 | Ubiquitination | SAKSAISKEIFAPLD CHHHHHHHHHCCCCC | 49.03 | 30230243 | |
21 | Ubiquitination | PLDERMLGAVQVKRR CCCHHHCCCHHCCCC | 17.85 | 30230243 | |
26 | Ubiquitination | MLGAVQVKRRTKKKI HCCCHHCCCCCCCCC | 21.04 | 30230243 | |
38 | Ubiquitination | KKIPFLATGGQGEYL CCCCEEEECCCCCEE | 43.95 | 30230243 | |
56 | Ubiquitination | CLSVTNKKPTQASIT EEEECCCCCCCCCEE | 56.20 | 30230243 | |
63 | O-linked_Glycosylation | KPTQASITKVKQFEG CCCCCCEEEEEEECC | 27.56 | 30059200 | |
64 | Ubiquitination | PTQASITKVKQFEGS CCCCCEEEEEEECCC | 45.85 | 30230243 | |
66 | Ubiquitination | QASITKVKQFEGSTS CCCEEEEEEECCCCH | 51.31 | 30230243 | |
68 | Ubiquitination | SITKVKQFEGSTSFV CEEEEEEECCCCHHH | 10.73 | 30230243 | |
76 | Ubiquitination | EGSTSFVRRSQWMLE CCCCHHHHHHHHHHH | 30.44 | 30230243 | |
78 | Ubiquitination | STSFVRRSQWMLEQL CCHHHHHHHHHHHHH | 20.03 | 30230243 | |
78 | Phosphorylation | STSFVRRSQWMLEQL CCHHHHHHHHHHHHH | 20.03 | 24076635 | |
146 | Phosphorylation | PEFINCQSKIMGGNS HHHHCCCCHHCCCCH | 26.75 | - | |
147 | Malonylation | EFINCQSKIMGGNSI HHHCCCCHHCCCCHH | 15.72 | 26320211 | |
153 | Phosphorylation | SKIMGGNSILHSAAD CHHCCCCHHHHHHHH | 29.78 | 27251275 | |
157 | Phosphorylation | GGNSILHSAADSVTS CCCHHHHHHHHHHHH | 23.00 | - | |
161 | Phosphorylation | ILHSAADSVTSAVQK HHHHHHHHHHHHHHH | 23.67 | - | |
191 | Ubiquitination | EEKTEDLKNSAQQFA HHHHHHHHHHHHHHH | 62.27 | 29967540 |
Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of STXB6_HUMAN !! |
Modified Location | Modified Residue | Modification | Function | Reference | ||
---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of STXB6_HUMAN !! |
* Distance = the distance between SAP position and PTM sites.
Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of STXB6_HUMAN !! |
Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
---|---|---|---|---|
ALS2_HUMAN | ALS2 | physical | 28514442 | |
STX7_HUMAN | STX7 | physical | 28514442 | |
STX1A_HUMAN | STX1A | physical | 28514442 | |
STX3_HUMAN | STX3 | physical | 28514442 | |
STX4_HUMAN | STX4 | physical | 28514442 | |
SNAG_HUMAN | NAPG | physical | 28514442 | |
STX8_HUMAN | STX8 | physical | 28514442 | |
VTI1B_HUMAN | VTI1B | physical | 28514442 | |
STX12_HUMAN | STX12 | physical | 28514442 | |
ATG7_HUMAN | ATG7 | physical | 28514442 | |
STX6_HUMAN | STX6 | physical | 28514442 | |
SNAA_HUMAN | NAPA | physical | 28514442 | |
SNP23_HUMAN | SNAP23 | physical | 28514442 |
Kegg Drug | ||||||
---|---|---|---|---|---|---|
DrugBank | ||||||
There are no disease associations of PTM sites. |
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