dbPTM

ST17B_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	ST17B_HUMAN
UniProt AC	O94768
Protein Name	Serine/threonine-protein kinase 17B
Gene Name	STK17B
Organism	Homo sapiens (Human).
Sequence Length	372
Subcellular Localization	Nucleus . Cell membrane. Endoplasmic reticulum-Golgi intermediate compartment. Colocalizes with STK17B at the plasma membrane..
Protein Description	Phosphorylates myosin light chains (By similarity). Acts as a positive regulator of apoptosis..
Protein Sequence	MSRRRFDCRSISGLLTTTPQIPIKMENFNNFYILTSKELGRGKFAVVRQCISKSTGQEYAAKFLKKRRRGQDCRAEILHEIAVLELAKSCPRVINLHEVYENTSEIILILEYAAGGEIFSLCLPELAEMVSENDVIRLIKQILEGVYYLHQNNIVHLDLKPQNILLSSIYPLGDIKIVDFGMSRKIGHACELREIMGTPEYLAPEILNYDPITTATDMWNIGIIAYMLLTHTSPFVGEDNQETYLNISQVNVDYSEETFSSVSQLATDFIQSLLVKNPEKRPTAEICLSHSWLQQWDFENLFHPEETSSSSQTQDHSVRSSEDKTSKSSCNGTCGDREDKENIPEDSSMVSKRFRFDDSLPNPHELVSDLLC

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
10	Phosphorylation	RRRFDCRSISGLLTT CCCCCCCCCCCCCCC	27.69	28102081
12	Phosphorylation	RFDCRSISGLLTTTP CCCCCCCCCCCCCCC	25.32	28102081
16	Phosphorylation	RSISGLLTTTPQIPI CCCCCCCCCCCCCCE	33.40	30108239
17	Phosphorylation	SISGLLTTTPQIPIK CCCCCCCCCCCCCEE	36.13	27080861
18	Phosphorylation	ISGLLTTTPQIPIKM CCCCCCCCCCCCEEE	14.14	27080861
37	Ubiquitination	NFYILTSKELGRGKF CEEEEEECCCCCCCC	52.29	-
43	Acetylation	SKELGRGKFAVVRQC ECCCCCCCCHHHHHH	28.87	25953088
43	Ubiquitination	SKELGRGKFAVVRQC ECCCCCCCCHHHHHH	28.87	-
53	Ubiquitination	VVRQCISKSTGQEYA HHHHHHCCCCCHHHH	31.93	-
62	Ubiquitination	TGQEYAAKFLKKRRR CCHHHHHHHHHHHHC	42.95	-
65	Ubiquitination	EYAAKFLKKRRRGQD HHHHHHHHHHHCCCC	47.57	-
88	Ubiquitination	IAVLELAKSCPRVIN HHHHHHHHHCCCEEE	66.28	-
185	Ubiquitination	VDFGMSRKIGHACEL EECCCCCCCCCHHHH	45.81	-
333	Phosphorylation	SKSSCNGTCGDREDK CCCCCCCCCCCCCCC	10.18	-
347	Phosphorylation	KENIPEDSSMVSKRF CCCCCCCCCHHHHHH	20.76	28509920
348	Phosphorylation	ENIPEDSSMVSKRFR CCCCCCCCHHHHHHC	35.21	28509920
351	Phosphorylation	PEDSSMVSKRFRFDD CCCCCHHHHHHCCCC	14.96	28509920
352	Ubiquitination	EDSSMVSKRFRFDDS CCCCHHHHHHCCCCC	44.11	-
359	Phosphorylation	KRFRFDDSLPNPHEL HHHCCCCCCCCHHHH	47.79	28348404

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of ST17B_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of ST17B_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of ST17B_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
ST17B_HUMAN	STK17B	physical	9786912
A4_HUMAN	APP	physical	21832049
KFA_HUMAN	AFMID	physical	26186194
KCIP2_HUMAN	KCNIP2	physical	26186194
REV3L_HUMAN	REV3L	physical	26496610
GTR1_HUMAN	SLC2A1	physical	26496610
TOX4_HUMAN	TOX4	physical	26496610
SCAM3_HUMAN	SCAMP3	physical	26496610
TRIB1_HUMAN	TRIB1	physical	26496610
ATX2L_HUMAN	ATXN2L	physical	26496610
MDN1_HUMAN	MDN1	physical	26496610
FAF2_HUMAN	FAF2	physical	26496610
WBP11_HUMAN	WBP11	physical	26496610
UBAC2_HUMAN	UBAC2	physical	26496610
KCIP2_HUMAN	KCNIP2	physical	28514442
TPM2_HUMAN	TPM2	physical	28514442

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of ST17B_HUMAN

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Quantitative phosphoproteomic analysis of T cell receptor signalingreveals system-wide modulation of protein-protein interactions."; Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,Rodionov V., Han D.K.; Sci. Signal. 2:RA46-RA46(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-10, AND MASSSPECTROMETRY.	19690332 [Abstract]
"Large-scale proteomics analysis of the human kinome."; Oppermann F.S., Gnad F., Olsen J.V., Hornberger R., Greff Z., Keri G.,Mann M., Daub H.; Mol. Cell. Proteomics 8:1751-1764(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-10, AND MASSSPECTROMETRY.	19369195 [Abstract]