dbPTM

KFA_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	KFA_HUMAN
UniProt AC	Q63HM1
Protein Name	Kynurenine formamidase {ECO:0000255\|HAMAP-Rule:MF_03014}
Gene Name	AFMID {ECO:0000255\|HAMAP-Rule:MF_03014}
Organism	Homo sapiens (Human).
Sequence Length	303
Subcellular Localization	Cytoplasm, cytosol . Nucleus . Predominantly cytosolic. Some fraction is nuclear.
Protein Description	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L-kynurenine, the second step in the kynurenine pathway of tryptophan degradation. Kynurenine may be further oxidized to nicotinic acid, NAD(H) and NADP(H). Required for elimination of toxic metabolites..
Protein Sequence	MMDVSGVGFPSKVPWKKMSAEELENQYCPSRWVVRLGAEEALRTYSQIGIEATTRARATRKSLLHVPYGDGEGEKVDIYFPDESSEALPFFLFFHGGYWQSGSKDESAFMVHPLTAQGVAVVIVAYGIAPKGTLDHMVDQVTRSVAFVQKRYPSNKGIYLCGHSAGAHLAAMMLLADWTKHGVTPNLRGFFLVSGVFDLEPIVYTSQNVALQLTLEDAQRNSPQLKVAQAQPVDPTCRVLVVVGQFDSPEFHRQSWEFYQTLCQGEWKASFEELHDVDHFEIVENLTQKDNVLTQIILKTIFQ

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	Reference
12 (in isoform 2)	Ubiquitination	-	-
16 (in isoform 2)	Ubiquitination	-	-
17 (in isoform 2)	Ubiquitination	-	-
27	Phosphorylation	AEELENQYCPSRWVV HHHHHHCCCCCHHHH	20561355
44	Phosphorylation	GAEEALRTYSQIGIE CHHHHHHHHHHHCHH	24719451
46	Phosphorylation	EEALRTYSQIGIEAT HHHHHHHHHHCHHHH	113320959
54	Phosphorylation	QIGIEATTRARATRK HHCHHHHHHCHHCCC	24719451
59	Phosphorylation	ATTRARATRKSLLHV HHHHCHHCCCHHEEC	24719451
61	Ubiquitination	TRARATRKSLLHVPY HHCHHCCCHHEECCC	29967540
122	Ubiquitination	TAQGVAVVIVAYGIA CCCCEEEEEEEECCC	27667366
179	Ubiquitination	MMLLADWTKHGVTPN HHHHHHHHHCCCCCC	27667366
191	Ubiquitination	TPNLRGFFLVSGVFD CCCCCCEEEEECEEE	27667366
226	Ubiquitination	QRNSPQLKVAQAQPV HHHCCCCEEEECCCC	27667366

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of KFA_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of KFA_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of KFA_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
PHS_HUMAN	PCBD1	physical	26344197

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of KFA_HUMAN

Related Literatures of Post-Translational Modification