S23A1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: S23A1_HUMAN
• UniProt AC: Q9UHI7
• Protein Name: Solute carrier family 23 member 1
• Gene Name: SLC23A1
• Organism: Homo sapiens (Human).
• Sequence Length: 598
• Subcellular Localization: Cell membrane ; Multi-pass membrane protein .
• Protein Description: Sodium/ascorbate cotransporter. Mediates electrogenic uptake of vitamin C, with a stoichiometry of 2 Na(+) for each ascorbate..
• Protein Sequence: MRAQEDLEGRTQHETTRDPSTPLPTEPKFDMLYKIEDVPPWYLCILLGFQHYLTCFSGTIAVPFLLAEALCVGHDQHMVSQLIGTIFTCVGITTLIQTTVGIRLPLFQASAFAFLVPAKAILALERWKCPPEEEIYGNWSLPLNTSHIWHPRIREVQGAIMVSSVVEVVIGLLGLPGALLNYIGPLTVTPTVSLIGLSVFQAAGDRAGSHWGISACSILLIILFSQYLRNLTFLLPVYRWGKGLTLLRIQIFKMFPIMLAIMTVWLLCYVLTLTDVLPTDPKAYGFQARTDARGDIMAIAPWIRIPYPCQWGLPTVTAAAVLGMFSATLAGIIESIGDYYACARLAGAPPPPVHAINRGIFTEGICCIIAGLLGTGNGSTSSSPNIGVLGITKVGSRRVVQYGAAIMLVLGTIGKFTALFSSLPDPILGGMFCTLFGMITAVGLSNLQFVDMNSSRNLFVLGFSMFFGLTLPNYLESNPGAINTGILEVDQILIVLLTTEMFVGGCLAFILDNTVPGSPEERGLIQWKAGAHANSDMSSSLKSYDFPIGMGIVKRITFLKYIPICPVFKGFSSSSKDQIAIPEDTPENTETASVCTKV

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
15	Phosphorylation	EGRTQHETTRDPSTP CCCCCCCCCCCCCCC	25.63	28857561
16	Phosphorylation	GRTQHETTRDPSTPL CCCCCCCCCCCCCCC	30.04	28857561
20	Phosphorylation	HETTRDPSTPLPTEP CCCCCCCCCCCCCCC	47.12	28857561
21	Phosphorylation	ETTRDPSTPLPTEPK CCCCCCCCCCCCCCC	33.94	21815630
25	Phosphorylation	DPSTPLPTEPKFDML CCCCCCCCCCCCCEE	73.02	-
138	N-linked_Glycosylation	PEEEIYGNWSLPLNT CHHHHCCCCCCCCCC	14.27	19379732
144	N-linked_Glycosylation	GNWSLPLNTSHIWHP CCCCCCCCCCCCCCH	37.28	19379732
477	Phosphorylation	TLPNYLESNPGAINT CCCHHHHHCCCCCCC	45.81	26074081
484	Phosphorylation	SNPGAINTGILEVDQ HCCCCCCCCCCCHHH	21.34	26074081
498	Phosphorylation	QILIVLLTTEMFVGG HHHHHHHHHCCHHHH	19.29	26074081
499	Phosphorylation	ILIVLLTTEMFVGGC HHHHHHHHCCHHHHH	25.97	26074081
572	Phosphorylation	CPVFKGFSSSSKDQI CCCCCCCCCCCCCEE	37.67	28857561
573	Phosphorylation	PVFKGFSSSSKDQIA CCCCCCCCCCCCEEE	36.05	28857561
574	Phosphorylation	VFKGFSSSSKDQIAI CCCCCCCCCCCEEEC	39.96	28857561
575	Phosphorylation	FKGFSSSSKDQIAIP CCCCCCCCCCEEECC	42.05	28857561
585	Phosphorylation	QIAIPEDTPENTETA EEECCCCCCCCCCCC	30.73	28857561
589	Phosphorylation	PEDTPENTETASVCT CCCCCCCCCCCCCEE	32.81	28857561
591	Phosphorylation	DTPENTETASVCTKV CCCCCCCCCCCEECC	23.38	28857561
593	Phosphorylation	PENTETASVCTKV-- CCCCCCCCCEECC--	25.74	29759185
596	Phosphorylation	TETASVCTKV----- CCCCCCEECC-----	32.46	28857561
597	Ubiquitination	ETASVCTKV------ CCCCCEECC------	40.60	33845483
601	Ubiquitination	VCTKV---------- CEECC----------		33845483

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of S23A1_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of S23A1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of S23A1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
SAHH2_HUMAN	AHCYL1	physical	25416956
MTUS2_HUMAN	MTUS2	physical	25416956
ATL4_HUMAN	ADAMTSL4	physical	25416956
KRA42_HUMAN	KRTAP4-2	physical	25416956
KR107_HUMAN	KRTAP10-7	physical	25416956
KR109_HUMAN	KRTAP10-9	physical	25416956
KR101_HUMAN	KRTAP10-1	physical	25416956
KR108_HUMAN	KRTAP10-8	physical	25416956
KR103_HUMAN	KRTAP10-3	physical	25416956
NT2NL_HUMAN	NOTCH2NL	physical	25416956

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.