PSA5_DROME - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: PSA5_DROME
• UniProt AC: Q95083
• Protein Name: Proteasome subunit alpha type-5
• Gene Name: Prosalpha5
• Organism: Drosophila melanogaster (Fruit fly).
• Sequence Length: 244
• Subcellular Localization: Cytoplasm. Nucleus.
• Protein Description: The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity..
• Protein Sequence: MFLTRSEYDRGVNTFSPEGRLFQVEYAIEAIKLGSTAIGICTPEGVVLAVEKRITSPLMVPSTVEKIVEVDKHIGCATSGLMADARTLIERARVECQNHWFVYNERMSIESCAQAVSTLAIQFGDSGDSDGAAAMSRPFGVAILFAGIEAGQPQLWHMDPSGTFVRHGAKAIGSGSEGAQQNLQDLFRPDLTLDEAIDISLNTLKQVMEEKLNSTNVEVMTMTKEREFYMFTKEEVEQHIKNIA

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
16	Phosphorylation	DRGVNTFSPEGRLFQ CCCCCCCCCCCCEEE	21.72	25749252
56	Phosphorylation	AVEKRITSPLMVPST EEEECCCCCCCCCCH	17.42	22817900
241	Acetylation	EEVEQHIKNIA---- HHHHHHHHHCC----	39.93	21791702
241	Ubiquitination	EEVEQHIKNIA---- HHHHHHHHHCC----	39.93	31113955

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of PSA5_DROME !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of PSA5_DROME !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of PSA5_DROME !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
PSA4_DROME	Prosalpha3	physical	22036573
PSA1_DROME	Prosalpha6	physical	22036573
PSB4_DROME	Prosbeta7	physical	22036573
PSA2_DROME	Prosalpha2	physical	22036573
PSA6_DROME	Prosalpha1	physical	22036573
PSB3_DROME	Prosbeta3	physical	22036573
PSA3_DROME	Prosalpha7	physical	22036573
PRS8_DROME	Rpt6	physical	22036573
ADRM1_DROME	Rpn13	physical	22036573
PSMD1_DROME	Rpn2	physical	22036573
PSDE_DROME	Rpn11	physical	22036573
PSMD6_DROME	Rpn7	physical	22036573
PSB2_DROME	Prosbeta4R2	physical	22036573
BGBP2_DROME	GNBP2	physical	22036573
PSD11_DROME	Rpn6	physical	22036573

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.