PPA6_HUMAN - dbPTM
PPA6_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID PPA6_HUMAN
UniProt AC Q9NPH0
Protein Name Lysophosphatidic acid phosphatase type 6
Gene Name ACP6
Organism Homo sapiens (Human).
Sequence Length 428
Subcellular Localization Mitochondrion .
Protein Description Hydrolyzes lysophosphatidic acid (LPA) containing a medium length fatty acid chain to the corresponding monoacylglycerol. Has highest activity with lysophosphatidic acid containing myristate (C14:0), monounsaturated oleate (C18:1) or palmitate (C16:0), and lower activity with C18:0 and C6:0 lysophosphatidic acid..
Protein Sequence MITGVFSMRLWTPVGVLTSLAYCLHQRRVALAELQEADGQCPVDRSLLKLKMVQVVFRHGARSPLKPLPLEEQVEWNPQLLEVPPQTQFDYTVTNLAGGPKPYSPYDSQYHETTLKGGMFAGQLTKVGMQQMFALGERLRKNYVEDIPFLSPTFNPQEVFIRSTNIFRNLESTRCLLAGLFQCQKEGPIIIHTDEADSEVLYPNYQSCWSLRQRTRGRRQTASLQPGISEDLKKVKDRMGIDSSDKVDFFILLDNVAAEQAHNLPSCPMLKRFARMIEQRAVDTSLYILPKEDRESLQMAVGPFLHILESNLLKAMDSATAPDKIRKLYLYAAHDVTFIPLLMTLGIFDHKWPPFAVDLTMELYQHLESKEWFVQLYYHGKEQVPRGCPDGLCPLDMFLNAMSVYTLSPEKYHALCSQTQVMEVGNEE
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure
ASA (%) Reference Orthologous
Protein Cluster
46PhosphorylationGQCPVDRSLLKLKMV
CCCCCCHHHHHHHEE
33.3224719451
116MethylationQYHETTLKGGMFAGQ
CCCEEECCCCCCHHH
51.86-
151PhosphorylationVEDIPFLSPTFNPQE
CCCCCCCCCCCCHHH
23.44110758795
175S-nitrosocysteineRNLESTRCLLAGLFQ
HCCHHHHHHHHHHHH
3.56-
175S-nitrosylationRNLESTRCLLAGLFQ
HCCHHHHHHHHHHHH
3.5619483679
183S-nitrosocysteineLLAGLFQCQKEGPII
HHHHHHHCCCCCCEE
4.97-
183S-nitrosylationLLAGLFQCQKEGPII
HHHHHHHCCCCCCEE
4.9719483679
210PhosphorylationPNYQSCWSLRQRTRG
CCHHHHHHHHHHHHC
20.2924719451
223PhosphorylationRGRRQTASLQPGISE
HCCHHHHCCCCCCCH
30.8126523019
229PhosphorylationASLQPGISEDLKKVK
HCCCCCCCHHHHHHH
30.8520044836
287PhosphorylationRAVDTSLYILPKEDR
HHCCCCEEECCHHHH
10.5222210691
296PhosphorylationLPKEDRESLQMAVGP
CCHHHHHHHHHHHHH
25.4646157961
331PhosphorylationKIRKLYLYAAHDVTF
HHHHHHHHHHCCCCH
6.5428555341
344PhosphorylationTFIPLLMTLGIFDHK
CHHHHHHHHCCCCCC
23.0828555341

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of PPA6_HUMAN !!

Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of PPA6_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10)
Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of PPA6_HUMAN !!

Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
ILK_HUMANILKphysical
17353931
RGS10_HUMANRGS10physical
17353931
RSU1_HUMANRSU1physical
17353931
DHX36_HUMANDHX36physical
17353931
DHCR7_HUMANDHCR7physical
17353931
LIMS1_HUMANLIMS1physical
17353931
ERH_HUMANERHphysical
17353931
S35F6_HUMANSLC35F6physical
16169070
GBG7_HUMANGNG7physical
16169070
FAM9B_HUMANFAM9Bphysical
24722188
PPA6_HUMANACP6physical
27499296
NDKM_HUMANNME4physical
27499296
STML2_HUMANSTOML2physical
27499296
ECH1_HUMANECH1physical
27499296
CYC_HUMANCYCSphysical
27499296
NRDC_HUMANNRD1physical
27499296
MPPB_HUMANPMPCBphysical
27499296
MPPA_HUMANPMPCAphysical
27499296
C1QBP_HUMANC1QBPphysical
27499296

Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of PPA6_HUMAN

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Related Literatures of Post-Translational Modification

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