UniProt ID | PPA6_HUMAN | |
---|---|---|
UniProt AC | Q9NPH0 | |
Protein Name | Lysophosphatidic acid phosphatase type 6 | |
Gene Name | ACP6 | |
Organism | Homo sapiens (Human). | |
Sequence Length | 428 | |
Subcellular Localization | Mitochondrion . | |
Protein Description | Hydrolyzes lysophosphatidic acid (LPA) containing a medium length fatty acid chain to the corresponding monoacylglycerol. Has highest activity with lysophosphatidic acid containing myristate (C14:0), monounsaturated oleate (C18:1) or palmitate (C16:0), and lower activity with C18:0 and C6:0 lysophosphatidic acid.. | |
Protein Sequence | MITGVFSMRLWTPVGVLTSLAYCLHQRRVALAELQEADGQCPVDRSLLKLKMVQVVFRHGARSPLKPLPLEEQVEWNPQLLEVPPQTQFDYTVTNLAGGPKPYSPYDSQYHETTLKGGMFAGQLTKVGMQQMFALGERLRKNYVEDIPFLSPTFNPQEVFIRSTNIFRNLESTRCLLAGLFQCQKEGPIIIHTDEADSEVLYPNYQSCWSLRQRTRGRRQTASLQPGISEDLKKVKDRMGIDSSDKVDFFILLDNVAAEQAHNLPSCPMLKRFARMIEQRAVDTSLYILPKEDRESLQMAVGPFLHILESNLLKAMDSATAPDKIRKLYLYAAHDVTFIPLLMTLGIFDHKWPPFAVDLTMELYQHLESKEWFVQLYYHGKEQVPRGCPDGLCPLDMFLNAMSVYTLSPEKYHALCSQTQVMEVGNEE | |
Overview of Protein Modification Sites with Functional and Structural Information | ||
* ASA = Accessible Surface Area
Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
---|---|---|---|---|---|
46 | Phosphorylation | GQCPVDRSLLKLKMV CCCCCCHHHHHHHEE | 33.32 | 24719451 | |
116 | Methylation | QYHETTLKGGMFAGQ CCCEEECCCCCCHHH | 51.86 | - | |
151 | Phosphorylation | VEDIPFLSPTFNPQE CCCCCCCCCCCCHHH | 23.44 | 110758795 | |
175 | S-nitrosocysteine | RNLESTRCLLAGLFQ HCCHHHHHHHHHHHH | 3.56 | - | |
175 | S-nitrosylation | RNLESTRCLLAGLFQ HCCHHHHHHHHHHHH | 3.56 | 19483679 | |
183 | S-nitrosocysteine | LLAGLFQCQKEGPII HHHHHHHCCCCCCEE | 4.97 | - | |
183 | S-nitrosylation | LLAGLFQCQKEGPII HHHHHHHCCCCCCEE | 4.97 | 19483679 | |
210 | Phosphorylation | PNYQSCWSLRQRTRG CCHHHHHHHHHHHHC | 20.29 | 24719451 | |
223 | Phosphorylation | RGRRQTASLQPGISE HCCHHHHCCCCCCCH | 30.81 | 26523019 | |
229 | Phosphorylation | ASLQPGISEDLKKVK HCCCCCCCHHHHHHH | 30.85 | 20044836 | |
287 | Phosphorylation | RAVDTSLYILPKEDR HHCCCCEEECCHHHH | 10.52 | 22210691 | |
296 | Phosphorylation | LPKEDRESLQMAVGP CCHHHHHHHHHHHHH | 25.46 | 46157961 | |
331 | Phosphorylation | KIRKLYLYAAHDVTF HHHHHHHHHHCCCCH | 6.54 | 28555341 | |
344 | Phosphorylation | TFIPLLMTLGIFDHK CHHHHHHHHCCCCCC | 23.08 | 28555341 |
Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of PPA6_HUMAN !! |
Modified Location | Modified Residue | Modification | Function | Reference | ||
---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of PPA6_HUMAN !! |
* Distance = the distance between SAP position and PTM sites.
Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of PPA6_HUMAN !! |
Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
---|---|---|---|---|
ILK_HUMAN | ILK | physical | 17353931 | |
RGS10_HUMAN | RGS10 | physical | 17353931 | |
RSU1_HUMAN | RSU1 | physical | 17353931 | |
DHX36_HUMAN | DHX36 | physical | 17353931 | |
DHCR7_HUMAN | DHCR7 | physical | 17353931 | |
LIMS1_HUMAN | LIMS1 | physical | 17353931 | |
ERH_HUMAN | ERH | physical | 17353931 | |
S35F6_HUMAN | SLC35F6 | physical | 16169070 | |
GBG7_HUMAN | GNG7 | physical | 16169070 | |
FAM9B_HUMAN | FAM9B | physical | 24722188 | |
PPA6_HUMAN | ACP6 | physical | 27499296 | |
NDKM_HUMAN | NME4 | physical | 27499296 | |
STML2_HUMAN | STOML2 | physical | 27499296 | |
ECH1_HUMAN | ECH1 | physical | 27499296 | |
CYC_HUMAN | CYCS | physical | 27499296 | |
NRDC_HUMAN | NRD1 | physical | 27499296 | |
MPPB_HUMAN | PMPCB | physical | 27499296 | |
MPPA_HUMAN | PMPCA | physical | 27499296 | |
C1QBP_HUMAN | C1QBP | physical | 27499296 |
Kegg Disease | ||||||
---|---|---|---|---|---|---|
There are no disease associations of PTM sites. | ||||||
OMIM Disease | ||||||
There are no disease associations of PTM sites. | ||||||
Kegg Drug | ||||||
There are no disease associations of PTM sites. | ||||||
DrugBank | ||||||
There are no disease associations of PTM sites. |
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