PPA6_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: PPA6_HUMAN
• UniProt AC: Q9NPH0
• Protein Name: Lysophosphatidic acid phosphatase type 6
• Gene Name: ACP6
• Organism: Homo sapiens (Human).
• Sequence Length: 428
• Subcellular Localization: Mitochondrion .
• Protein Description: Hydrolyzes lysophosphatidic acid (LPA) containing a medium length fatty acid chain to the corresponding monoacylglycerol. Has highest activity with lysophosphatidic acid containing myristate (C14:0), monounsaturated oleate (C18:1) or palmitate (C16:0), and lower activity with C18:0 and C6:0 lysophosphatidic acid..
• Protein Sequence: MITGVFSMRLWTPVGVLTSLAYCLHQRRVALAELQEADGQCPVDRSLLKLKMVQVVFRHGARSPLKPLPLEEQVEWNPQLLEVPPQTQFDYTVTNLAGGPKPYSPYDSQYHETTLKGGMFAGQLTKVGMQQMFALGERLRKNYVEDIPFLSPTFNPQEVFIRSTNIFRNLESTRCLLAGLFQCQKEGPIIIHTDEADSEVLYPNYQSCWSLRQRTRGRRQTASLQPGISEDLKKVKDRMGIDSSDKVDFFILLDNVAAEQAHNLPSCPMLKRFARMIEQRAVDTSLYILPKEDRESLQMAVGPFLHILESNLLKAMDSATAPDKIRKLYLYAAHDVTFIPLLMTLGIFDHKWPPFAVDLTMELYQHLESKEWFVQLYYHGKEQVPRGCPDGLCPLDMFLNAMSVYTLSPEKYHALCSQTQVMEVGNEE

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
46	Phosphorylation	GQCPVDRSLLKLKMV CCCCCCHHHHHHHEE	33.32	24719451
116	Methylation	QYHETTLKGGMFAGQ CCCEEECCCCCCHHH	51.86	-
151	Phosphorylation	VEDIPFLSPTFNPQE CCCCCCCCCCCCHHH	23.44	110758795
175	S-nitrosocysteine	RNLESTRCLLAGLFQ HCCHHHHHHHHHHHH	3.56	-
175	S-nitrosylation	RNLESTRCLLAGLFQ HCCHHHHHHHHHHHH	3.56	19483679
183	S-nitrosocysteine	LLAGLFQCQKEGPII HHHHHHHCCCCCCEE	4.97	-
183	S-nitrosylation	LLAGLFQCQKEGPII HHHHHHHCCCCCCEE	4.97	19483679
210	Phosphorylation	PNYQSCWSLRQRTRG CCHHHHHHHHHHHHC	20.29	24719451
223	Phosphorylation	RGRRQTASLQPGISE HCCHHHHCCCCCCCH	30.81	26523019
229	Phosphorylation	ASLQPGISEDLKKVK HCCCCCCCHHHHHHH	30.85	20044836
287	Phosphorylation	RAVDTSLYILPKEDR HHCCCCEEECCHHHH	10.52	22210691
296	Phosphorylation	LPKEDRESLQMAVGP CCHHHHHHHHHHHHH	25.46	46157961
331	Phosphorylation	KIRKLYLYAAHDVTF HHHHHHHHHHCCCCH	6.54	28555341
344	Phosphorylation	TFIPLLMTLGIFDHK CHHHHHHHHCCCCCC	23.08	28555341

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of PPA6_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of PPA6_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of PPA6_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
ILK_HUMAN	ILK	physical	17353931
RGS10_HUMAN	RGS10	physical	17353931
RSU1_HUMAN	RSU1	physical	17353931
DHX36_HUMAN	DHX36	physical	17353931
DHCR7_HUMAN	DHCR7	physical	17353931
LIMS1_HUMAN	LIMS1	physical	17353931
ERH_HUMAN	ERH	physical	17353931
S35F6_HUMAN	SLC35F6	physical	16169070
GBG7_HUMAN	GNG7	physical	16169070
FAM9B_HUMAN	FAM9B	physical	24722188
PPA6_HUMAN	ACP6	physical	27499296
NDKM_HUMAN	NME4	physical	27499296
STML2_HUMAN	STOML2	physical	27499296
ECH1_HUMAN	ECH1	physical	27499296
CYC_HUMAN	CYCS	physical	27499296
NRDC_HUMAN	NRD1	physical	27499296
MPPB_HUMAN	PMPCB	physical	27499296
MPPA_HUMAN	PMPCA	physical	27499296
C1QBP_HUMAN	C1QBP	physical	27499296

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.