PAX2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: PAX2_HUMAN
• UniProt AC: Q02962
• Protein Name: Paired box protein Pax-2
• Gene Name: PAX2
• Organism: Homo sapiens (Human).
• Sequence Length: 417
• Subcellular Localization: Nucleus.
• Protein Description: Transcription factor that may have a role in kidney cell differentiation. [PubMed: 24676634 Has a critical role in the development of the urogenital tract, the eyes, and the CNS.]
• Protein Sequence: MDMHCKADPFSAMHPGHGGVNQLGGVFVNGRPLPDVVRQRIVELAHQGVRPCDISRQLRVSHGCVSKILGRYYETGSIKPGVIGGSKPKVATPKVVDKIAEYKRQNPTMFAWEIRDRLLAEGICDNDTVPSVSSINRIIRTKVQQPFHPTPDGAGTGVTAPGHTIVPSTASPPVSSASNDPVGSYSINGILGIPRSNGEKRKRDEVEVYTDPAHIRGGGGLHLVWTLRDVSEGSVPNGDSQSGVDSLRKHLRADTFTQQQLEALDRVFERPSYPDVFQASEHIKSEQGNEYSLPALTPGLDEVKSSLSASTNPELGSNVSGTQTYPVVTGRDMASTTLPGYPPHVPPTGQGSYPTSTLAGMVPGSEFSGNPYSHPQYTAYNEAWRFSNPALLSSPYYYSAAPRGSAPAAAAAAYDRH

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
73	Phosphorylation	SKILGRYYETGSIKP HHHHCCHHCCCCCCC	12.97	18083107
92	Phosphorylation	GSKPKVATPKVVDKI CCCCCCCCHHHHHHH	26.99	20860994
98	Acetylation	ATPKVVDKIAEYKRQ CCHHHHHHHHHHHHH	32.00	23954790
133	Phosphorylation	NDTVPSVSSINRIIR CCCCCCHHHHHHHHH	29.82	-
210	Phosphorylation	RDEVEVYTDPAHIRG CCEEEEECCHHHHCC	40.45	19690332
226	Phosphorylation	GGLHLVWTLRDVSEG CCEEEEEEEEECCCC	12.39	1378753
231	Phosphorylation	VWTLRDVSEGSVPNG EEEEEECCCCCCCCC	40.29	27732954
234	Phosphorylation	LRDVSEGSVPNGDSQ EEECCCCCCCCCCCC	30.28	27732954
246	Phosphorylation	DSQSGVDSLRKHLRA CCCCCHHHHHHHHHH	27.89	29507054
403	Methylation	YYYSAAPRGSAPAAA CCCCCCCCCCCHHHH	47.15	115486547

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of PAX2_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of PAX2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of PAX2_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
PAXI1_HUMAN	PAXIP1	physical	10908331
BEX1_HUMAN	BEX1	physical	25640309
BLID_HUMAN	BLID	physical	25640309
GLCE_HUMAN	GLCE	physical	25640309
I13R2_HUMAN	IL13RA2	physical	25640309
KLK6_HUMAN	KLK6	physical	25640309
KLK9_HUMAN	KLK9	physical	25640309
MRC2_HUMAN	MRC2	physical	25640309
PRD14_HUMAN	PRDM14	physical	25640309
RSLAB_HUMAN	RASL10B	physical	25640309
SNAI1_HUMAN	SNAI1	physical	25640309
TRI25_HUMAN	TRIM25	physical	25640309
VPS45_HUMAN	VPS45	physical	25640309
NSD3_HUMAN	WHSC1L1	physical	25640309

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• 120330: Papillorenal syndrome (PAPRS)
• : Note=Defects in PAX2 can be responsible for isolated renal hypodysplasia and oligomeganephronia (OMN). This is a rare congenital and usually sporadic anomaly characterized by bilateral renal hypoplasia, with a reduced number of enlarged nephrons and without urinary tract abnormalities.
• 616002:
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Quantitative phosphoproteomic analysis of T cell receptor signalingreveals system-wide modulation of protein-protein interactions.";
Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,Rodionov V., Han D.K.;
Sci. Signal. 2:RA46-RA46(2009).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-226, AND MASSSPECTROMETRY.
PubMed: 19690332