OTC_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: OTC_HUMAN
• UniProt AC: P00480
• Protein Name: Ornithine carbamoyltransferase, mitochondrial
• Gene Name: OTC
• Organism: Homo sapiens (Human).
• Sequence Length: 354
• Subcellular Localization: Mitochondrion matrix.
• Protein Sequence: MLFNLRILLNNAAFRNGHNFMVRNFRCGQPLQNKVQLKGRDLLTLKNFTGEEIKYMLWLSADLKFRIKQKGEYLPLLQGKSLGMIFEKRSTRTRLSTETGFALLGGHPCFLTTQDIHLGVNESLTDTARVLSSMADAVLARVYKQSDLDTLAKEASIPIINGLSDLYHPIQILADYLTLQEHYSSLKGLTLSWIGDGNNILHSIMMSAAKFGMHLQAATPKGYEPDASVTKLAEQYAKENGTKLLLTNDPLEAAHGGNVLITDTWISMGQEEEKKKRLQAFQGYQVTMKTAKVAASDWTFLHCLPRKPEEVDDEVFYSPRSLVFPEAENRKWTIMAVMVSLLTDYSPQLQKPKF

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
46	Acetylation	GRDLLTLKNFTGEEI CCEEEEECCCCHHHH	44.79	20167786
55	Phosphorylation	FTGEEIKYMLWLSAD CCHHHHHHHHHHCCC	11.78	-
70	Acetylation	LKFRIKQKGEYLPLL CEEECCCCCCEEEEC	49.02	-
70	Succinylation	LKFRIKQKGEYLPLL CEEECCCCCCEEEEC	49.02	-
70	Succinylation	LKFRIKQKGEYLPLL CEEECCCCCCEEEEC	49.02	-
80	Succinylation	YLPLLQGKSLGMIFE EEEECCCCCHHEEEE	29.55	-
80	Succinylation	YLPLLQGKSLGMIFE EEEECCCCCHHEEEE	29.55	-
88	Succinylation	SLGMIFEKRSTRTRL CHHEEEECCCCCCEE	40.68	-
88	Succinylation	SLGMIFEKRSTRTRL CHHEEEECCCCCCEE	40.68	-
88	2-Hydroxyisobutyrylation	SLGMIFEKRSTRTRL CHHEEEECCCCCCEE	40.68	-
88	Acetylation	SLGMIFEKRSTRTRL CHHEEEECCCCCCEE	40.68	19318352
132	Phosphorylation	TDTARVLSSMADAVL HHHHHHHHHHHHHHH	18.40	25072903
133	Phosphorylation	DTARVLSSMADAVLA HHHHHHHHHHHHHHH	17.52	25072903
144	Succinylation	AVLARVYKQSDLDTL HHHHHHHCCCCHHHH	40.23	-
144	Acetylation	AVLARVYKQSDLDTL HHHHHHHCCCCHHHH	40.23	27178108
144	Succinylation	AVLARVYKQSDLDTL HHHHHHHCCCCHHHH	40.23	-
146	Phosphorylation	LARVYKQSDLDTLAK HHHHHCCCCHHHHHH	35.67	-
221	Acetylation	HLQAATPKGYEPDAS EECCCCCCCCCCCCH	70.53	-
221	Succinylation	HLQAATPKGYEPDAS EECCCCCCCCCCCCH	70.53	-
221	Succinylation	HLQAATPKGYEPDAS EECCCCCCCCCCCCH	70.53	-
223	Phosphorylation	QAATPKGYEPDASVT CCCCCCCCCCCCHHH	30.34	-
231	Acetylation	EPDASVTKLAEQYAK CCCCHHHHHHHHHHH	43.47	92453
231	Succinylation	EPDASVTKLAEQYAK CCCCHHHHHHHHHHH	43.47	-
231	Succinylation	EPDASVTKLAEQYAK CCCCHHHHHHHHHHH	43.47	-
238	Acetylation	KLAEQYAKENGTKLL HHHHHHHHHCCCEEE	46.94	-
238	Succinylation	KLAEQYAKENGTKLL HHHHHHHHHCCCEEE	46.94	-
238	Succinylation	KLAEQYAKENGTKLL HHHHHHHHHCCCEEE	46.94	-
243	Acetylation	YAKENGTKLLLTNDP HHHHCCCEEEEECCH	38.24	-
274	Succinylation	SMGQEEEKKKRLQAF CCCCHHHHHHHHHHH	67.86	-
274	Succinylation	SMGQEEEKKKRLQAF CCCCHHHHHHHHHHH	67.86	-
284	Phosphorylation	RLQAFQGYQVTMKTA HHHHHCCCCEEEEEH	6.77	-
289	Succinylation	QGYQVTMKTAKVAAS CCCCEEEEEHHHHHC	35.65	-
289	Succinylation	QGYQVTMKTAKVAAS CCCCEEEEEHHHHHC	35.65	-
292	Succinylation	QVTMKTAKVAASDWT CEEEEEHHHHHCCCE	37.32	-
292	Succinylation	QVTMKTAKVAASDWT CEEEEEHHHHHCCCE	37.32	-
292	Acetylation	QVTMKTAKVAASDWT CEEEEEHHHHHCCCE	37.32	-
307	Succinylation	FLHCLPRKPEEVDDE EEEECCCCCCCCCCC	55.64	-
307	Acetylation	FLHCLPRKPEEVDDE EEEECCCCCCCCCCC	55.64	-
307	Succinylation	FLHCLPRKPEEVDDE EEEECCCCCCCCCCC	55.64	-
317	Phosphorylation	EVDDEVFYSPRSLVF CCCCCCCCCCCHHCC	23.96	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of OTC_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
88	K	Acetylation	Acetylation at Lys-88 negatively regulates ornithine carbamoyltransferase activity in response to nutrient signals.	19318352

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of OTC_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
TBB1_HUMAN	TUBB1	physical	28514442
DPOG1_HUMAN	POLG	physical	28514442
NPS3A_HUMAN	NIPSNAP3A	physical	28514442
NDUF7_HUMAN	NDUFAF7	physical	28514442
ADRO_HUMAN	FDXR	physical	28514442
ATPF1_HUMAN	ATPAF1	physical	28514442
GLSK_HUMAN	GLS	physical	28514442
SYNM_HUMAN	NARS2	physical	28514442
RTL8C_HUMAN	FAM127A	physical	28514442
SYHM_HUMAN	HARS2	physical	28514442
CPSM_HUMAN	CPS1	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• 311250: Ornithine carbamoyltransferase deficiency (OTCD)
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• DB00155: L-Citrulline
• DB00129: L-Ornithine

Related Literatures of Post-Translational Modification

Acetylation

"Lysine 88 acetylation negatively regulates ornithinecarbamoyltransferase activity in response to nutrient signals.";
Yu W., Lin Y., Yao J., Huang W., Lei Q., Xiong Y., Zhao S., Guan K.L.;
J. Biol. Chem. 284:13669-13675(2009).
Cited for: ACETYLATION AT LYS-88, AND ENZYME REGULATION.
PubMed: 19318352