| UniProt ID | NRX1B_HUMAN | |
|---|---|---|
| UniProt AC | P58400 | |
| Protein Name | Neurexin-1-beta | |
| Gene Name | NRXN1 | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 472 | |
| Subcellular Localization |
Cell membrane Single-pass type I membrane protein. Cell junction, synapse. Localized on the pre-synaptic membrane.. |
|
| Protein Description | Neuronal cell surface protein that may be involved in cell recognition and cell adhesion by forming intracellular junctions through binding to neuroligins. May play a role in formation or maintenance of synaptic junctions. May mediate intracellular signaling. May play a role in angiogenesis (By similarity).. | |
| Protein Sequence | MYQRMLRCGAELGSPGGGGGGGGGGGAGGRLALLWIVPLTLSGLLGVAWGASSLGAHHIHHFHGSSKHHSVPIAIYRSPASLRGGHAGTTYIFSKGGGQITYKWPPNDRPSTRADRLAIGFSTVQKEAVLVRVDSSSGLGDYLELHIHQGKIGVKFNVGTDDIAIEESNAIINDGKYHVVRFTRSGGNATLQVDSWPVIERYPAGNNDNERLAIARQRIPYRLGRVVDEWLLDKGRQLTIFNSQATIIIGGKEQGQPFQGQLSGLYYNGLKVLNMAAENDANIAIVGNVRLVGEVPSSMTTESTATAMQSEMSTSIMETTTTLATSTARRGKPPTKEPISQTTDDILVASAECPSDDEDIDPCEPSSGGLANPTRAGGREPYPGSAEVIRESSSTTGMVVGIVAAAALCILILLYAMYKYRNRDEGSYHVDESRNYISNSAQSNGAVVKEKQPSSAKSSNKNKKNKDKEYYV | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 188 | N-linked_Glycosylation | RFTRSGGNATLQVDS EEEECCCCEEEEEEC | 33.02 | UniProtKB CARBOHYD | |
| 419 | Ubiquitination | ILLYAMYKYRNRDEG HHHHHHHHHCCCCCC | 53.23 | - | |
| 424 | Phosphorylation | MYKYRNRDEGSYHVD HHHHCCCCCCCCCCC | 40.20 | - | |
| 425 | Phosphorylation | YKYRNRDEGSYHVDE HHHCCCCCCCCCCCC | 46.53 | - | |
| 428 | Phosphorylation | RNRDEGSYHVDESRN CCCCCCCCCCCCCCC | 38.57 | - |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of NRX1B_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of NRX1B_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of NRX1B_HUMAN !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
| NLGN1_HUMAN | NLGN1 | physical | 14522992 | |
| NLGN1_HUMAN | NLGN1 | physical | 8576240 | |
| NLGN2_HUMAN | NLGN2 | physical | 8576240 | |
| NLGN3_HUMAN | NLGN3 | physical | 8576240 | |
| PDZD2_HUMAN | PDZD2 | physical | 12421765 | |
| SI1L1_HUMAN | SIPA1L1 | physical | 12421765 | |
| MYO16_HUMAN | MYO16 | physical | 12421765 | |
| MACF1_HUMAN | MACF1 | physical | 12421765 | |
| RHG26_HUMAN | ARHGAP26 | physical | 27173435 | |
| ELOA1_HUMAN | TCEB3 | physical | 27173435 | |
| RHG10_HUMAN | ARHGAP10 | physical | 27173435 | |
| TULP1_HUMAN | TULP1 | physical | 27173435 |
| Kegg Disease | ||||||
|---|---|---|---|---|---|---|
| OMIM Disease | ||||||
| There are no disease associations of PTM sites. | ||||||
| Kegg Drug | ||||||
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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