TULP1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: TULP1_HUMAN
• UniProt AC: O00294
• Protein Name: Tubby-related protein 1
• Gene Name: TULP1
• Organism: Homo sapiens (Human).
• Sequence Length: 542
• Subcellular Localization: Cytoplasm . Cell membrane ; Peripheral membrane protein ; Cytoplasmic side . Secreted. Cell junction, synapse. Detected at synapses between photoreceptor cells and second-order neurons. Does not have a cleavable signal peptide and is secreted by an a
• Protein Description: Required for normal development of photoreceptor synapses. Required for normal photoreceptor function and for long-term survival of photoreceptor cells. Interacts with cytoskeleton proteins and may play a role in protein transport in photoreceptor cells (By similarity). Binds lipids, especially phosphatidylinositol 3-phosphate, phosphatidylinositol 4-phosphate, phosphatidylinositol 5-phosphate, phosphatidylinositol 3,4-bisphosphate, phosphatidylinositol 4,5-bisphosphate, phosphatidylinositol 3,4,5-bisphosphate, phosphatidylserine and phosphatidic acid (in vitro). Contribute to stimulation of phagocytosis of apoptotic retinal pigment epithelium (RPE) cells and macrophages..
• Protein Sequence: MPLRDETLREVWASDSGHEEESLSPEAPRRPKQRPAPAQRLRKKRTEAPESPCPTGSKPRKPGAGRTGRPREEPSPDPAQARAPQTVYARFLRDPEAKKRDPRETFLVARAPDAEDEEEEEEEDEEDEEEEAEEKKEKILLPPKKPLREKSSADLKERRAKAQGPRGDLGSPDPPPKPLRVRNKEAPAGEGTKMRKTKKKGSGEADKDPSGSPASARKSPAAMFLVGEGSPDKKALKKKGTPKGARKEEEEEEEAATVIKKSNQKGKAKGKGKKKAKEERAPSPPVEVDEPREFVLRPAPQGRTVRCRLTRDKKGMDRGMYPSYFLHLDTEKKVFLLAGRKRKRSKTANYLISIDPTNLSRGGENFIGKLRSNLLGNRFTVFDNGQNPQRGYSTNVASLRQELAAVIYETNVLGFRGPRRMTVIIPGMSAENERVPIRPRNASDGLLVRWQNKTLESLIELHNKPPVWNDDSGSYTLNFQGRVTQASVKNFQIVHADDPDYIVLQFGRVAEDAFTLDYRYPLCALQAFAIALSSFDGKLACE

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
184	Ubiquitination	KPLRVRNKEAPAGEG CCCEECCCCCCCCCC	44.69	-
200	Acetylation	KMRKTKKKGSGEADK CCCCCCCCCCCCCCC	60.92	20167786
202	Phosphorylation	RKTKKKGSGEADKDP CCCCCCCCCCCCCCC	42.19	-
207 (in isoform 2)	Acetylation	-	77.81	-
210	Phosphorylation	GEADKDPSGSPASAR CCCCCCCCCCCHHHC	63.13	22210691
215	Phosphorylation	DPSGSPASARKSPAA CCCCCCHHHCCCCCE	31.80	22210691
220 (in isoform 2)	Acetylation	-	27.37	-
260	Acetylation	EEAATVIKKSNQKGK HHHHHHHHHHHHHCC	45.90	20167786
273	Acetylation	GKAKGKGKKKAKEER CCCCCCCCHHHHHHC	55.37	20167786
347	Phosphorylation	RKRKRSKTANYLISI CCCCCCCCCCEEEEE	22.75	30576142
350	Phosphorylation	KRSKTANYLISIDPT CCCCCCCEEEEECCC	11.71	22817900
357	Phosphorylation	YLISIDPTNLSRGGE EEEEECCCCCCCCCC	45.07	22817900
360	Phosphorylation	SIDPTNLSRGGENFI EECCCCCCCCCCCHH	30.83	30576142
422	Phosphorylation	FRGPRRMTVIIPGMS CCCCCCEEEEECCCC	13.52	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of TULP1_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of TULP1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of TULP1_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of TULP1_HUMAN !!

Drug and Disease Associations

• Kegg Disease
• H00527: Retinitis pigmentosa (RP)
• H00837: Leber congenital amaurosis (LCR)
• OMIM Disease
• 600132: Retinitis pigmentosa 14 (RP14)
• 613843: Leber congenital amaurosis 15 (LCA15)
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.