MYO16_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: MYO16_HUMAN
• UniProt AC: Q9Y6X6
• Protein Name: Unconventional myosin-XVI
• Gene Name: MYO16 {ECO:0000312|HGNC:HGNC:29822}
• Organism: Homo sapiens (Human).
• Sequence Length: 1858
• Subcellular Localization: Cytoplasm . Found in puncta in soma and processes of astrocytes and dissociated cerebellar cells with the morphology of migrating granule cells.
• Protein Description: Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Their highly divergent tails are presumed to bind to membranous compartments, which would be moved relative to actin filaments. May be involved in targeting of the catalytic subunit of protein phosphatase 1 during brain development. Activates PI3K and concomitantly recruits the WAVE1 complex to the close vicinity of PI3K and regulates neuronal morphogenesis (By similarity)..
• Protein Sequence: MEIDQCLLESLPLGQRQRLVKRMRCEQIKAYYEREKAFQKQEGFLKRLKHAKNPKVHFNLTDMLQDAIIHHNDKEVLRLLKEGADPHTLVSSGGSLLHLCARYDNAFIAEILIDRGVNVNHQDEDFWTPMHIACACDNPDIVLLLVLAGANVLLQDVNGNIPLDYAVEGTESSSILLTYLDENGVDLTSLRQMKLQRPMSMLTDVKHFLSSGGNVNEKNDEGVTLLHMACASGYKEVVSLILEHGGDLNIVDDQYWTPLHLAAKYGQTNLVKLLLMHQANPHLVNCNEEKASDIAASEFIEEMLLKAEIAWEEKMKEPLSASTLAQEEPYEEIIHDLPVLSSKLSPLVLPIAKQDSLLEKDIMFKDATKGLCKQQSQDSIPENPMMSGSTKPEQVKLMPPAPNDDLATLSELNDGSLLYEIQKRFGNNQIYTFIGDILLLVNPYKELPIYSSMVSQLYFSSSGKLCSSLPPHLFSCVERAFHQLFREQRPQCFILSGERGSGKSEASKQIIRHLTCRAGASRATLDSRFKHVVCILEAFGHAKTTLNDLSSCFIKYFELQFCERKQQLTGARIYTYLLEKSRLVSQPLGQSNFLIFYLLMDGLSAEEKYGLHLNNLCAHRYLNQTIQDDASTGERSLNREKLAVLKRALNVVGFSSLEVENLFVILAAILHLGDIRFTALNEGNSAFVSDLQLLEQVAGMLQVSTDELASALTTDIQYFKGDMIIRRHTIQIAEFFRDLLAKSLYSRLFSFLVNTMNSCLHSQDEQKSMQTLDIGILDIFGFEEFQKNEFEQLCVNMTNEKMHHYINEVLFLHEQVECVQEGVTMETAYSPGNQNGVLDFFFQKPSGFLTLLDEESQMIWSVESNFPKKLQSLLESSNTNAVYSPMKDGNGNVALKDHGTAFTIMHYAGRVMYDVVGAIEKNKDSLSQNLLFVMKTSENVVINHLFQSKLSQTGSLVSAYPSFKFRGHKSALLSKKMTASSIIGENKNYLELSKLLKKKGTSTFLQRLERGDPVTIASQLRKSLMDIIGKLQKCTPHFIHCIRPNNSKLPDTFDNFYVSAQLQYIGVLEMVKIFRYGYPVRLSFSDFLSRYKPLADTFLREKKEQSAAERCRLVLQQCKLQGWQMGVRKVFLKYWHADQLNDLCLQLQRKIITCQKVIRGFLARQHLLQRISIRQQEVTSINSFLQNTEDMGLKTYDALVIQNASDIARENDRLRSEMNAPYHKEKLEVRNMQEEGSKRTDDKSGPRHFHPSSMSVCAAVDGLGQCLVGPSIWSPSLHSVFSMDDSSSLPSPRKQPPPKPKRDPNTRLSASYEAVSACLSAAREAANEALARPRPHSDDYSTMKKIPPRKPKRSPNTKLSGSYEEISGSRPGDARPAGAPGAAARVLTPGTPQCALPPAAPPGDEDDSEPVYIEMLGHAARPDSPDPGESVYEEMKCCLPDDGGPGAGSFLLHGASPPLLHRAPEDEAAGPPGDACDIPPPFPNLLPHRPPLLVFPPTPVTCSPASDESPLTPLEVKKLPVLETNLKYPVQPEGSSPLSPQYSKSQKGDGDRPASPGLALFNGSGRASPPSTPPPPPPPPGPPPAPYRPCAHLAFPPEPAPVNAGKAGPSAEAPKVHPKPNSAPVAGPCSSFPKIPYSPVKATRADARKAGSSASPPAPYSPPSSRPLSSPLDELASLFNSGRSVLRKSAAGRKIREAEGFETNMNISSRDDPSTSEITSETQDRNANNHGIQLSNSLSSAITAENGNSISNGLPEEDGYSRLSISGTGTSTFQRHRDSHTTQVIHQLRLSENESVALQELLDWRRKLCEEGQDWQQILHHAEPRVPPPPPCKKPSLLKKPEGASCNRLPSELWDTTI

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
200	Phosphorylation	MKLQRPMSMLTDVKH HHCCCCHHHHHHHHH	17.21	29116813
210	Phosphorylation	TDVKHFLSSGGNVNE HHHHHHHHCCCCCCC	26.45	29116813
211	Phosphorylation	DVKHFLSSGGNVNEK HHHHHHHCCCCCCCC	53.52	29116813
356	Phosphorylation	LPIAKQDSLLEKDIM HCHHCCCCHHHCCCC	32.15	24719451
496	Phosphorylation	RPQCFILSGERGSGK CCCEEEEECCCCCCC	33.52	24719451
501	Phosphorylation	ILSGERGSGKSEASK EEECCCCCCCCHHHH	49.63	24719451
504	Phosphorylation	GERGSGKSEASKQII CCCCCCCCHHHHHHH	41.75	24719451
580	Ubiquitination	IYTYLLEKSRLVSQP HHHHHHHHCCCCCCC	40.62	-
621	Phosphorylation	NNLCAHRYLNQTIQD CHHHHHHHHCHHHHC	10.51	22210691
631	Phosphorylation	QTIQDDASTGERSLN HHHHCCCCCCCCCCC	43.89	22210691
632	Phosphorylation	TIQDDASTGERSLNR HHHCCCCCCCCCCCH	44.79	22210691
746	Phosphorylation	LLAKSLYSRLFSFLV HHHHHHHHHHHHHHH	28.00	24719451
750	Phosphorylation	SLYSRLFSFLVNTMN HHHHHHHHHHHHHHH	23.43	27067055
755	Phosphorylation	LFSFLVNTMNSCLHS HHHHHHHHHHHHHCC	15.39	27067055
948	Phosphorylation	VINHLFQSKLSQTGS HHHHHHHHCCCCCCC	28.38	-
951	Phosphorylation	HLFQSKLSQTGSLVS HHHHHCCCCCCCCCC	29.45	25850435
953	Phosphorylation	FQSKLSQTGSLVSAY HHHCCCCCCCCCCCC	25.92	25850435
955	Phosphorylation	SKLSQTGSLVSAYPS HCCCCCCCCCCCCCC	29.05	25850435
978	Phosphorylation	ALLSKKMTASSIIGE HHHCCCCCHHHHHCC	32.06	29759185
980	Phosphorylation	LSKKMTASSIIGENK HCCCCCHHHHHCCCC	16.95	29759185
981	Phosphorylation	SKKMTASSIIGENKN CCCCCHHHHHCCCCC	18.76	29759185
989	Phosphorylation	IIGENKNYLELSKLL HHCCCCCHHHHHHHH	11.80	29759185
993	Phosphorylation	NKNYLELSKLLKKKG CCCHHHHHHHHHHHC	16.33	27762562
1030	Ubiquitination	SLMDIIGKLQKCTPH HHHHHHHHHHHCCCC	37.02	-
1076	Phosphorylation	EMVKIFRYGYPVRLS HHHHHHCCCCCEEEE	15.40	-
1078	Phosphorylation	VKIFRYGYPVRLSFS HHHHCCCCCEEEEHH	6.93	-
1091	Phosphorylation	FSDFLSRYKPLADTF HHHHHHHHHHHHHHH	17.37	-
1179	Phosphorylation	SIRQQEVTSINSFLQ HCCHHHHHHHHHHHH	24.12	-
1237	Phosphorylation	RNMQEEGSKRTDDKS HCCHHCCCCCCCCCC	23.42	29083192
1291	Phosphorylation	DDSSSLPSPRKQPPP CCCCCCCCCCCCCCC	42.50	24719451
1306	Phosphorylation	KPKRDPNTRLSASYE CCCCCCCCCCHHHHH	38.07	-
1309	Phosphorylation	RDPNTRLSASYEAVS CCCCCCCHHHHHHHH	16.33	-
1316	Phosphorylation	SASYEAVSACLSAAR HHHHHHHHHHHHHHH	21.95	-
1320	Phosphorylation	EAVSACLSAAREAAN HHHHHHHHHHHHHHH	21.55	-
1337	Phosphorylation	LARPRPHSDDYSTMK HCCCCCCCCCCCHHC	34.56	28555341
1340	Phosphorylation	PRPHSDDYSTMKKIP CCCCCCCCCHHCCCC	15.84	29449344
1341	Phosphorylation	RPHSDDYSTMKKIPP CCCCCCCCHHCCCCC	29.08	29449344
1342	Phosphorylation	PHSDDYSTMKKIPPR CCCCCCCHHCCCCCC	27.12	29449344
1528	Phosphorylation	VLETNLKYPVQPEGS EEECCCCCCCCCCCC	16.29	-
1536	Phosphorylation	PVQPEGSSPLSPQYS CCCCCCCCCCCCCCC	40.49	25627689
1539	Phosphorylation	PEGSSPLSPQYSKSQ CCCCCCCCCCCCCCC	17.22	25159151
1555	Phosphorylation	GDGDRPASPGLALFN CCCCCCCCCCEEECC	23.37	25159151
1637	Phosphorylation	SSFPKIPYSPVKATR CCCCCCCCCCCCCCH	29.13	30108239
1638	Phosphorylation	SFPKIPYSPVKATRA CCCCCCCCCCCCCHH	20.19	30108239
1643	Phosphorylation	PYSPVKATRADARKA CCCCCCCCHHHHHHC	22.22	30108239
1652	Phosphorylation	ADARKAGSSASPPAP HHHHHCCCCCCCCCC	27.82	28634298
1653	Phosphorylation	DARKAGSSASPPAPY HHHHCCCCCCCCCCC	31.67	28634298
1655	Phosphorylation	RKAGSSASPPAPYSP HHCCCCCCCCCCCCC	33.11	28634298
1660	Phosphorylation	SASPPAPYSPPSSRP CCCCCCCCCCCCCCC	35.60	28634298
1661	Phosphorylation	ASPPAPYSPPSSRPL CCCCCCCCCCCCCCC	29.31	28634298
1664	Phosphorylation	PAPYSPPSSRPLSSP CCCCCCCCCCCCCCC	42.22	28634298
1836	Phosphorylation	PPPCKKPSLLKKPEG CCCCCCCHHCCCCCC	56.04	24719451

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of MYO16_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of MYO16_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of MYO16_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
NCKP1_HUMAN	NCKAP1	physical	21946561
CYFP2_HUMAN	CYFIP2	physical	21946561
CYFP1_HUMAN	CYFIP1	physical	21946561
P85A_HUMAN	PIK3R1	physical	21946561
RHG26_HUMAN	ARHGAP26	physical	21946561
ACOT9_HUMAN	ACOT9	physical	21946561

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.