MGN_ARATH - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: MGN_ARATH
• UniProt AC: O23676
• Protein Name: Protein mago nashi homolog {ECO:0000305}
• Gene Name: MAGO {ECO:0000303|PubMed:24416299}
• Organism: Arabidopsis thaliana (Mouse-ear cress).
• Sequence Length: 150
• Subcellular Localization: Nucleus, nucleolus . Nucleus speckle . Nucleus . Cytoplasm, P-body . Cytoplasm . Nucleocytoplasmic shuttling protein. Travels to the cytoplasm as part of the exon junction complex (EJC) bound to mRNA.
• Protein Description: Core component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junctions on mRNAs. The EJC is a dynamic structure consisting of core proteins and several peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. The EJC marks the position of the exon-exon junction in the mature mRNA for the gene expression machinery and the core components remain bound to spliced mRNAs throughout all stages of mRNA metabolism thereby influencing downstream processes including nuclear mRNA export, subcellular mRNA localization, translation efficiency and nonsense-mediated mRNA decay (NMD). The MAGO-Y14 heterodimer inhibits the ATPase activity of EIF4A3, thereby trapping the ATP-bound EJC core onto spliced mRNA in a stable conformation. The MAGO-Y14 heterodimer interacts with the EJC key regulator PYM leading to EJC disassembly in the cytoplasm (By similarity). Can increase in vitro the expression from reporter constructs that contain leader introns required for the expression of different genes. In association with MAGO and PYM, participates in intron-mediated enhancement of gene expression. [PubMed: 21676911 The MAGO-Y14 heterodimer works synergistically with the NMD pathway to regulate male gametophyte development]
• Protein Sequence: MAAEEATEFYLRYYVGHKGKFGHEFLEFEFREDGKLRYANNSNYKNDTIIRKEVFLTPAVLKECKRIVSESEILKEDDNNWPEPDRVGKQELEIVLGNEHISFATSKIGSLVDCQSSNDPEGLRIFYYLVQDLKCLVFSLISLHFKIKPI

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MAAEEATEF ------CCHHHHHHH	24.47	22223895

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of MGN_ARATH !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of MGN_ARATH !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of MGN_ARATH !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
PEX5_ARATH	PEX5	physical	21798944
HS23M_ARATH	HSP23.6-MITO	physical	21798944
THO4D_ARATH	ALY4	physical	19435936
IF4A1_ARATH	EIF4A1	physical	19435936
RH2_ARATH	EIF4A-III	physical	19435936
MGN_ARATH	MAGO	physical	19435936
THO4A_ARATH	AT5G59950	physical	19435936
THO4B_ARATH	AT5G02530	physical	19435936
THO4C_ARATH	AT1G66260	physical	19435936

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.