PEX5_ARATH - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: PEX5_ARATH
• UniProt AC: Q9FMA3
• Protein Name: Peroxisome biogenesis protein 5
• Gene Name: PEX5
• Organism: Arabidopsis thaliana (Mouse-ear cress).
• Sequence Length: 728
• Subcellular Localization: Cytoplasm . Peroxisome membrane ; Peripheral membrane protein .
• Protein Description: Import receptor for peroxisomal-targeting signal one (PTS1). A receptor-cargo complex composed of PEX5, PEX7, a PTS1-containing protein and a PTS2-containing protein is targeted to peroxisomes during import. Necessary for the developmental elimination of obsolete peroxisome matrix proteins..
• Protein Sequence: MAMRDLVNGGAACAVPGSSSSSNPLGALTNALLGSSSKTQERLKEIPNANRSGPRPQFYSEDQQIRSLPGSELDQPLLQPGAQGSEFFRGFRSVDQNGLGAAWDEVQQGGPMPPMGPMFEPVQPTFEGPPQRVLSNFLHSFVESSRGGIPFRPAPVPVLGLSQSDKQCIRDRSSIMARHFFADRGEEFINSQVNALLSSLDIDDGIQARGHVPGRFRELDDYWNESQAVVKPNLHPADNWAAEFNQHGMDHGGPDSWVQSFEQQHGVNGWATEFEQGQSQLMSSQMRSMDMQNIAAMEQTRKLAHTLSQDGNPKFQNSRFLQFVSKMSRGELIIDENQVKQASAPGEWATEYEQQYLGPPSWADQFANEKLSHGPEQWADEFASGRGQQETAEDQWVNEFSKLNVDDWIDEFAEGPVGDSSADAWANAYDEFLNEKNAGKQTSGVYVFSDMNPYVGHPEPMKEGQELFRKGLLSEAALALEAEVMKNPENAEGWRLLGVTHAENDDDQQAIAAMMRAQEADPTNLEVLLALGVSHTNELEQATALKYLYGWLRNHPKYGAIAPPELADSLYHADIARLFNEASQLNPEDADVHIVLGVLYNLSREFDRAITSFQTALQLKPNDYSLWNKLGATQANSVQSADAISAYQQALDLKPNYVRAWANMGISYANQGMYKESIPYYVRALAMNPKADNAWQYLRLSLSCASRQDMIEACESRNLDLLQKEFPL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
308	Phosphorylation	RKLAHTLSQDGNPKF HHHHHHHCCCCCCCC	27.64	23111157
328	Phosphorylation	LQFVSKMSRGELIID HHHHHHHCCCCEEEC	40.65	25561503

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
-	K	Ubiquitination	E3 ubiquitin ligase	PEX12	Q9M841	PMID:22199232

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of PEX5_ARATH !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of PEX5_ARATH !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
LACS7_ARATH	LACS7	physical	16256065
TOE2_ARATH	TOE2	physical	21798944
PEX14_ARATH	PEX14	physical	24879895
PEX7_ARATH	PEX7	physical	24879895
PEX14_ARATH	PEX14	physical	11978862
PEX7_ARATH	PEX7	physical	11978862

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.