dbPTM

THO4D_ARATH - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	THO4D_ARATH
UniProt AC	Q6NQ72
Protein Name	THO complex subunit 4D
Gene Name	ALY4 {ECO:0000303\|PubMed:15299117}
Organism	Arabidopsis thaliana (Mouse-ear cress).
Sequence Length	288
Subcellular Localization	Nucleus, nucleoplasm . Nucleus, nucleolus .
Protein Description	Export adapter involved in nuclear export of spliced and unspliced mRNA. [PubMed: 11432957 Plays a role in disease resistance. Mediates multiple defense responses triggered by NEP1, including stomatal closure, hypersensitive cell death (HCD) and defense-related gene expression]
Protein Sequence	MSGALNMTLDEIVKRGKTARSGGRGISRGRGRGRGGGGRGAGPARRGPLAVNARPSSFTINKPVRRVRSLPWQSGLFEDGLRAAGASGVEVGTRLHVTNLDQGVTNEDIRELFSEIGEVERYAIHYDKNGRPSGTAEVVYPRRSDAFQALKKYNNVLLDGRPMRLEILGGNNSSEAPLSGRVNVNVTGLNGRLKRTVVIQQGGGGRGRVRGGRGGRGPAPTVSRRLPIHNQQGGGMRGGRGGFRARGRGNGGRGRGGGRGNGKKPVEKSAADLDKDLESYHADAMNTS

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	Reference
2	Acetylation	------MSGALNMTL ------CCCCCCCCH	22223895
8	Phosphorylation	MSGALNMTLDEIVKR CCCCCCCCHHHHHHC	19880383
69	Phosphorylation	KPVRRVRSLPWQSGL CCCEECCCCCCCCCC	30291188
74	Phosphorylation	VRSLPWQSGLFEDGL CCCCCCCCCCCHHHH	30291188
144	Phosphorylation	EVVYPRRSDAFQALK EEEECCCHHHHHHHH	25561503
173	Phosphorylation	EILGGNNSSEAPLSG EECCCCCCCCCCCCC	30291188
174	Phosphorylation	ILGGNNSSEAPLSGR ECCCCCCCCCCCCCC	25561503

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of THO4D_ARATH !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of THO4D_ARATH !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of THO4D_ARATH !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
THO4D_ARATH	ALY4	physical	19435936

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of THO4D_ARATH

Related Literatures of Post-Translational Modification