MAFA_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: MAFA_MOUSE
• UniProt AC: Q8CF90
• Protein Name: Transcription factor MafA
• Gene Name: Mafa
• Organism: Mus musculus (Mouse).
• Sequence Length: 359
• Subcellular Localization: Nucleus . Detected in nuclei of pancreas islet beta cells.
• Protein Description: Acts as a transcriptional factor. Specifically binds the insulin enhancer element RIPE3b. Cooperates synergistically with NEUROD1 and PDX1. Phosphorylation by GSK3 increases its transcriptional activity and is required for its oncogenic activity (By similarity). Regulates the insulin gene transcription. Involved either as an oncogene or as a tumor suppressor, depending on the cell context..
• Protein Sequence: MAAELAMGAELPSSPLAIEYVNDFDLMKFEVKKEPPEAERFCHRLPPGSLSSTPLSTPCSSVPSSPSFCAPSPGTGGGAGGGGSAAQAGGAPGPPSGGPGTVGGASGKAVLEDLYWMSGYQHHLNPEALNLTPEDAVEALIGSGHHGAHHGAHHPAAAAAYEAFRGQSFAGGGGADDMGAGHHHGAHHTAHHHHSAHHHHHHHHHHGGSGHHGGGAGHGGGGAGHHVRLEERFSDDQLVSMSVRELNRQLRGFSKEEVIRLKQKRRTLKNRGYAQSCRFKRVQQRHILESEKCQLQSQVEQLKLEVGRLAKERDLYKEKYEKLAGRGGPGGAGGAGFPREPSPAQAGPGAAKGAPDFFL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
13	Phosphorylation	AMGAELPSSPLAIEY HCCCCCCCCCCEEEE	58.16	20208071
14	Phosphorylation	MGAELPSSPLAIEYV CCCCCCCCCCEEEEC	23.22	20208071
32	Sumoylation	DLMKFEVKKEPPEAE HCEEEEECCCCCHHH	44.19	-
49	Phosphorylation	CHRLPPGSLSSTPLS HHCCCCCCCCCCCCC	30.74	20208071
53	Phosphorylation	PPGSLSSTPLSTPCS CCCCCCCCCCCCCCC	25.52	20208071
57	Phosphorylation	LSSTPLSTPCSSVPS CCCCCCCCCCCCCCC	35.68	20208071
60	Phosphorylation	TPLSTPCSSVPSSPS CCCCCCCCCCCCCCC	35.26	-
61	Phosphorylation	PLSTPCSSVPSSPSF CCCCCCCCCCCCCCC	44.77	20208071
65	Phosphorylation	PCSSVPSSPSFCAPS CCCCCCCCCCCCCCC	20.63	20208071
96	Phosphorylation	GGAPGPPSGGPGTVG CCCCCCCCCCCCCCC	60.56	20208071
118	Phosphorylation	LEDLYWMSGYQHHLN HHHHHHHHCCCCCCC	21.87	20208071
132	Phosphorylation	NPEALNLTPEDAVEA CHHHHCCCHHHHHHH	24.45	20208071
143	Phosphorylation	AVEALIGSGHHGAHH HHHHHHCCCCCCCCC	28.14	20208071
161	Phosphorylation	HPAAAAAYEAFRGQS CHHHHHHHHHHCCCC	11.76	20208071
168	Phosphorylation	YEAFRGQSFAGGGGA HHHHCCCCCCCCCCC	21.64	20208071
234	Phosphorylation	VRLEERFSDDQLVSM EEHHHHCCHHHHHHH	46.64	20208071
240	Phosphorylation	FSDDQLVSMSVRELN CCHHHHHHHHHHHHH	17.58	20208071
242	Phosphorylation	DDQLVSMSVRELNRQ HHHHHHHHHHHHHHH	15.54	20208071
254	Phosphorylation	NRQLRGFSKEEVIRL HHHHCCCCHHHHHHH	41.82	20208071
276	Phosphorylation	KNRGYAQSCRFKRVQ HHCCHHHHHHHHHHH	10.09	20208071
290	Phosphorylation	QQRHILESEKCQLQS HHHHHHHHHHHHHHH	38.62	20208071
297	Phosphorylation	SEKCQLQSQVEQLKL HHHHHHHHHHHHHHH	44.80	20208071
316	Phosphorylation	LAKERDLYKEKYEKL HHHHHHHHHHHHHHH	22.76	-
320	Phosphorylation	RDLYKEKYEKLAGRG HHHHHHHHHHHCCCC	21.27	20208071
342	Phosphorylation	AGFPREPSPAQAGPG CCCCCCCCHHHCCCC	28.28	29895711

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
49	S	Phosphorylation	Kinase	GSK3B	P49841	PSP
53	T	Phosphorylation	Kinase	GSK3B	P49841	PSP
57	T	Phosphorylation	Kinase	GSK3B	P49841	PSP
61	S	Phosphorylation	Kinase	GSK3B	P49841	PSP
65	S	Phosphorylation	Kinase	GSK3B	P49841	PSP

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of MAFA_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of MAFA_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
PSME3_MOUSE	Psme3	physical	21830322
KAT2B_MOUSE	Kat2b	physical	26180087
PDX1_MOUSE	Pdx1	physical	26180087
RBBP5_MOUSE	Rbbp5	physical	26180087
ASH2L_MOUSE	Ash2l	physical	26180087
WDR5_MOUSE	Wdr5	physical	26180087
DPY30_MOUSE	Dpy30	physical	26180087
KDM6A_MOUSE	Kdm6a	physical	26180087
PAXI1_MOUSE	Paxip1	physical	26180087
PGR1A_MOUSE	Pagr1a	physical	26180087

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.