PGR1A_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: PGR1A_MOUSE
• UniProt AC: Q99L02
• Protein Name: PAXIP1-associated glutamate-rich protein 1A {ECO:0000312|MGI:MGI:1914528}
• Gene Name: Pagr1a {ECO:0000312|MGI:MGI:1914528}
• Organism: Mus musculus (Mouse).
• Sequence Length: 253
• Subcellular Localization: Nucleus .
• Protein Description: Its association with the histone methyltransferase MLL2/MLL3 complex is suggesting a role in epigenetic transcriptional activation. However, in association with PAXIP1/PTIP is proposed to function at least in part independently of the MLL2/MLL3 complex. Proposed to be recruited by PAXIP1 to sites of DNA damage where the PAGR1:PAXIP1 complex is required for cell survival in response to DNA damage independently of the MLL2/MLL3 complex. [PubMed: 19124460 However, its function in DNA damage has been questioned]
• Protein Sequence: MSLALGHGTIAGSTAAPLSEEGEVTSGLQALAVEDTGGPSVSASKAEEEGKGSQEEAGREGSRPEEALEAPSAASDERAEGEAEDWCVPCSDEEVELPANGQSWMPPPSEIQRLYELLATQGTLELQAEILPRRPPTPEAQSEEERSDEEPEAKEEEEEKPHMPTEFDFDDEPMTPKDSLIDRRRTPGSSARSQKREARLDKVLSDMKRHKKLEEQILRTGRDLFSLDSEGPSPTSPPLRSSGNSLFPRQRKY

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
42	Phosphorylation	DTGGPSVSASKAEEE ECCCCCCCHHHHHHC		25338131
44	Phosphorylation	GGPSVSASKAEEEGK CCCCCCHHHHHHCCC		25338131
53	Phosphorylation	AEEEGKGSQEEAGRE HHHCCCCCHHHHHCC		27087446
72	Phosphorylation	EEALEAPSAASDERA HHHHCCCCCCCCHHH		28066266
75	Phosphorylation	LEAPSAASDERAEGE HCCCCCCCCHHHCCC		28066266
91	Phosphorylation	EDWCVPCSDEEVELP CCCEEECCCCCEECC		28576409
137	Phosphorylation	ILPRRPPTPEAQSEE ECCCCCCCHHHCCHH		25521595
142	Phosphorylation	PPTPEAQSEEERSDE CCCHHHCCHHHHCCC		25521595
147	Phosphorylation	AQSEEERSDEEPEAK HCCHHHHCCCCCHHH		25521595
175	Phosphorylation	DFDDEPMTPKDSLID CCCCCCCCCCCHHHC		29550500
205	Phosphorylation	ARLDKVLSDMKRHKK HHHHHHHHHHHHHHH		28066266
226	Phosphorylation	RTGRDLFSLDSEGPS HHCHHHCCCCCCCCC		25619855
229	Phosphorylation	RDLFSLDSEGPSPTS HHHCCCCCCCCCCCC		25619855
233	Phosphorylation	SLDSEGPSPTSPPLR CCCCCCCCCCCCCCC		24925903
235	Phosphorylation	DSEGPSPTSPPLRSS CCCCCCCCCCCCCCC		25521595
236	Phosphorylation	SEGPSPTSPPLRSSG CCCCCCCCCCCCCCC		24925903
241	Phosphorylation	PTSPPLRSSGNSLFP CCCCCCCCCCCCCCC		27600695

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of PGR1A_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of PGR1A_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of PGR1A_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of PGR1A_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.