KDM6A_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: KDM6A_MOUSE
• UniProt AC: O70546
• Protein Name: Lysine-specific demethylase 6A
• Gene Name: Kdm6a
• Organism: Mus musculus (Mouse).
• Sequence Length: 1401
• Subcellular Localization: Nucleus .
• Protein Description: Histone demethylase that specifically demethylates 'Lys-27' of histone H3, thereby playing a central role in histone code. Demethylates trimethylated and dimethylated but not monomethylated H3 'Lys-27'. Plays a central role in regulation of posterior development, by regulating HOX gene expression. Demethylation of 'Lys-27' of histone H3 is concomitant with methylation of 'Lys-4' of histone H3, and regulates the recruitment of the PRC1 complex and monoubiquitination of histone H2A (By similarity). Plays a demethylase-independent role in chromatin remodeling to regulate T-box family member-dependent gene expression. [PubMed: 21095589]
• Protein Sequence: MKSCGVSLATAAAAAAAAAFGDEEKKMAAGKASGESEEASPSLTAEEREALGGLDSRLFGFVRFHEDGARMKALLGKAVRCYESLILKAEGKVESDFFCQLGHFNLLLEDYPKALSAYQRYYSLQSDYWKNAAFLYGLGLVYFHYNAFQWAIKAFQEVLYVDPSFCRAKEIHLRLGLMFKVNTDYESSLKHFQLALVDCNPCTLSNAEIQFHIAHLYETQRKYHSAKEAYEQLLQTENLSAQVKATILQQLGWMHHTVDLLGDKATKESYAIQYLQKSLEADPNSGQSWYFLGRCYSSIGKVQDAFISYRQSIDKSEASADTWCSIGVLYQQQNQPMDALQAYICAVQLDHGHAAAWMDLGTLYESCNQPQDAIKCYLNATRSKNCSNTSGLAARIKYLQAQLCNLPQGSLQNKTKLLPSIEEAWSLPIPAELTSRQGAMNTAQQNTSDNWSGGNAPPPVEQQTHSWCLTPQKLQHLEQLRANRNNLNPAQKLMLEQLESQFVLMQQHQMRQTGVAQVRPTGILNGPTVDSSLPTNSVSGQQPQLPLTRMPSVSQPGVHTACPRQTLANGPFSAGHVPCSTSRTLGSTDTVLIGNNHVTGSGSNGNVPYLQRNAPTLPHNRTNLTSSTEEPWKNQLSNSTQGLHKGPSSHLAGPNGERPLSSTGPSQHLQAAGSGIQNQNGHPTLPSNSVTQGAALNHLSSHTATSGGQQGITLTKESKPSGNTLTVPETSRQTGETPNSTASVEGLPNHVHQVMADAVCSPSHGDSKSPGLLSSDNPQLSALLMGKANNNVGPGTCDKVNNIHPTVHTKTDNSVASSPSSAISTATPSPKSTEQTTTNSVTSLNSPHSGLHTINGEGMEESQSPIKTDLLLVSHRPSPQIIPSMSVSIYPSSAEVLKACRNLGKNGLSNSSILLDKCPPPRPPSSPYPPLPKDKLNPPTPSIYLENKRDAFFPPLHQFCTNPNNPVTVIRGLAGALKLDLGLFSTKTLVEANNEHMVEVRTQLLQPADENWDPTGTKKIWHCESNRSHTTIAKYAQYQASSFQESLREENEKRSHHKDHSDSESTSSDNSGKRRKGPFKTIKFGTNIDLSDDKKWKLQLHELTKLPAFVRVVSAGNLLSHVGHTILGMNTVQLYMKVPGSRTPGHQENNNFCSVNINIGPGDCEWFVVPEGYWGVLNDFCEKNNLNFLMGSWWPNLEDLYEANVPVYRFIQRPGDLVWINAGTVHWVQAIGWCNNIAWNVGPLTACQYKLAVERYEWNKLQNVKSIVPMVHLSWNMARNIKVSDPKLFEMIKYCLLRTLKQCQTLREALIAAGKEIIWHGRTKEEPAHYCSICEVEVFDLLFVTNESNSRKTYIVHCQDCARKTSGNLENFVVLEQYKMEDLMQVYDQFTLAPPLPSASS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
290	Phosphorylation	PNSGQSWYFLGRCYS CCCCCCEEECCHHHH	8.32	-
397	Ubiquitination	SGLAARIKYLQAQLC CHHHHHHHHHHHHHC	34.06	-
519	Methylation	QTGVAQVRPTGILNG HHCCCCCCCCCCCCC	15.81	24129315
549	Methylation	QPQLPLTRMPSVSQP CCCCCCCCCCCCCCC	42.57	24129315
554	O-linked_Glycosylation	LTRMPSVSQPGVHTA CCCCCCCCCCCCCCC	34.69	30059200
719	Acetylation	ITLTKESKPSGNTLT EEEECCCCCCCCEEE	44.27	23954790
769	Phosphorylation	PSHGDSKSPGLLSSD CCCCCCCCCCCCCCC	28.31	21082442
774	Phosphorylation	SKSPGLLSSDNPQLS CCCCCCCCCCCHHHH	40.46	21183079
775	Phosphorylation	KSPGLLSSDNPQLSA CCCCCCCCCCHHHHH	41.18	23984901
781	Phosphorylation	SSDNPQLSALLMGKA CCCCHHHHHHHHCCC	16.18	28285833
799	Acetylation	VGPGTCDKVNNIHPT CCCCCCCCCCCCCCE	49.35	23806337
806	Phosphorylation	KVNNIHPTVHTKTDN CCCCCCCEEECCCCC	15.68	-
809	Phosphorylation	NIHPTVHTKTDNSVA CCCCEEECCCCCCCC	31.16	-
811	Phosphorylation	HPTVHTKTDNSVASS CCEEECCCCCCCCCC	41.38	26239621
814	Phosphorylation	VHTKTDNSVASSPSS EECCCCCCCCCCCCC	23.13	26239621
817	Phosphorylation	KTDNSVASSPSSAIS CCCCCCCCCCCCCCC	40.40	28833060
818	Phosphorylation	TDNSVASSPSSAIST CCCCCCCCCCCCCCC	21.04	24723360
820	Phosphorylation	NSVASSPSSAISTAT CCCCCCCCCCCCCCC	34.06	28833060
821	Phosphorylation	SVASSPSSAISTATP CCCCCCCCCCCCCCC	32.76	28833060
824	Phosphorylation	SSPSSAISTATPSPK CCCCCCCCCCCCCCC	16.23	28833060
825	Phosphorylation	SPSSAISTATPSPKS CCCCCCCCCCCCCCC	28.56	28833060
827	Phosphorylation	SSAISTATPSPKSTE CCCCCCCCCCCCCCC	25.12	28833060
829	Phosphorylation	AISTATPSPKSTEQT CCCCCCCCCCCCCCC	40.37	24723360
846	Phosphorylation	NSVTSLNSPHSGLHT CCCCCCCCCCCCCEE	29.32	25338131
864	Phosphorylation	EGMEESQSPIKTDLL CCCCCCCCCCCCCEE	37.56	25338131
874	Phosphorylation	KTDLLLVSHRPSPQI CCCEEEEECCCCCCC	17.47	26643407
878	Phosphorylation	LLVSHRPSPQIIPSM EEEECCCCCCCCCCC	29.41	26643407
940	Phosphorylation	KDKLNPPTPSIYLEN CCCCCCCCCCEECCC	30.81	28066266
942	Phosphorylation	KLNPPTPSIYLENKR CCCCCCCCEECCCCC	26.75	28066266
944	Phosphorylation	NPPTPSIYLENKRDA CCCCCCEECCCCCCC	16.58	28066266
1055	Phosphorylation	REENEKRSHHKDHSD HHHHHHHHCCCCCCC	40.80	-
1061	Phosphorylation	RSHHKDHSDSESTSS HHCCCCCCCCCCCCC	53.63	27087446
1063	Phosphorylation	HHKDHSDSESTSSDN CCCCCCCCCCCCCCC	36.14	23375375
1065	Phosphorylation	KDHSDSESTSSDNSG CCCCCCCCCCCCCCC	37.23	23684622
1066	Phosphorylation	DHSDSESTSSDNSGK CCCCCCCCCCCCCCC	28.35	23684622
1067	Phosphorylation	HSDSESTSSDNSGKR CCCCCCCCCCCCCCC	45.00	23684622
1068	Phosphorylation	SDSESTSSDNSGKRR CCCCCCCCCCCCCCC	40.68	23684622
1303	S-nitrosylation	LLRTLKQCQTLREAL HHHHHHHHHHHHHHH	2.97	21278135
1303	S-nitrosocysteine	LLRTLKQCQTLREAL HHHHHHHHHHHHHHH	2.97	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of KDM6A_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of KDM6A_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of KDM6A_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of KDM6A_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Solid tumor proteome and phosphoproteome analysis by high resolutionmass spectrometry.";
Zanivan S., Gnad F., Wickstroem S.A., Geiger T., Macek B., Cox J.,Faessler R., Mann M.;
J. Proteome Res. 7:5314-5326(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1061, AND MASSSPECTROMETRY.
PubMed: 19367708

"Phosphoproteomic analysis of the developing mouse brain.";
Ballif B.A., Villen J., Beausoleil S.A., Schwartz D., Gygi S.P.;
Mol. Cell. Proteomics 3:1093-1101(2004).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-829, AND MASSSPECTROMETRY.
PubMed: 15345747