KLH28_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: KLH28_HUMAN
• UniProt AC: Q9NXS3
• Protein Name: Kelch-like protein 28
• Gene Name: KLHL28
• Organism: Homo sapiens (Human).
• Sequence Length: 571
• Protein Sequence: MDHTSPTYMLANLTHLHSEQLLQGLNLLRQHHELCDIILRVGDVKIHAHKVVLASVSPYFKAMFTGNLSEKENSEVEFQCIDETALQAIVEYAYTGTVFISQDTVESLLPAANLLQIKLVLKECCAFLESQLDPGNCIGISRFAETYGCRDLYLAATKYICQNFEAVCQTEEFFELTHADLDEIVSNDCLNVATEETVFYALESWIKYDVQERQKYLAQLLNSVRLPLLSVKFLTRLYEANHLIRDDRTCKHLLNEALKYHFMPEHRLSHQTVLMTRPRCAPKVLCAVGGKSGLFACLDSVEMYFPQNDSWIGLAPLNIPRYEFGICVLDQKVYVIGGIATNVRPGVTIRKHENSVECWNPDTNTWTSLERMNESRSTLGVVVLAGELYALGGYDGQSYLQSVEKYIPKIRKWQPVAPMTTTRSCFAAAVLDGMIYAIGGYGPAHMNSVERYDPSKDSWEMVASMADKRIHFGVGVMLGFIFVVGGHNGVSHLSSIERYDPHQNQWTVCRPMKEPRTGVGAAVIDNYLYVVGGHSGSSYLNTVQKYDPISDTWLDSAGMIYCRCNFGLTAL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
157	Phosphorylation	RDLYLAATKYICQNF HHHHHHHHHHHHHHH	20.83	20726782
216	Phosphorylation	DVQERQKYLAQLLNS CHHHHHHHHHHHHHH	10.03	21659604
223	Phosphorylation	YLAQLLNSVRLPLLS HHHHHHHHCCHHHHH	14.48	21659604
230	Phosphorylation	SVRLPLLSVKFLTRL HCCHHHHHHHHHHHH	30.83	24719451
232	Ubiquitination	RLPLLSVKFLTRLYE CHHHHHHHHHHHHHH	31.14	-
251	Ubiquitination	IRDDRTCKHLLNEAL CCCCHHHHHHHHHHH	36.35	-
283	Ubiquitination	TRPRCAPKVLCAVGG CCCCCCCEEEEECCC	29.34	-
334	Phosphorylation	CVLDQKVYVIGGIAT EEECCEEEEECCEEC	8.06	24719451
351	Ubiquitination	RPGVTIRKHENSVEC CCCCEEEECCCCEEE	51.96	-
389	Phosphorylation	VVLAGELYALGGYDG EEEECEEHHCCCCCC	8.76	-
406	Phosphorylation	YLQSVEKYIPKIRKW HHHHHHHHHHHHCCC	14.67	-
412	Ubiquitination	KYIPKIRKWQPVAPM HHHHHHCCCCCCCCC	54.37	-
513	Ubiquitination	WTVCRPMKEPRTGVG EEEEEECCCCCCCCC	68.22	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of KLH28_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of KLH28_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of KLH28_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
KLH14_HUMAN	KLHL14	physical	28514442
IPP_HUMAN	IPP	physical	28514442
FXL17_HUMAN	FBXL17	physical	28514442
KLH21_HUMAN	KLHL21	physical	28514442
NUDC3_HUMAN	NUDCD3	physical	28514442
KLH26_HUMAN	KLHL26	physical	28514442
KLH24_HUMAN	KLHL24	physical	28514442
KLH13_HUMAN	KLHL13	physical	28514442
AKA11_HUMAN	AKAP11	physical	28514442
CUL7_HUMAN	CUL7	physical	28514442
KAPCB_HUMAN	PRKACB	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.