HXA9_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: HXA9_MOUSE
• UniProt AC: P09631
• Protein Name: Homeobox protein Hox-A9
• Gene Name: Hoxa9
• Organism: Mus musculus (Mouse).
• Sequence Length: 271
• Subcellular Localization: Nucleus.
• Protein Description: Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Required for induction of E-selectin and VCAM-1, on the endothelial cells surface at sites of inflammation (By similarity)..
• Protein Sequence: MATTGALGNYYVDSFLLGADAADELGAGRYAPGTLGQPPRQAAALAEHPDFSPCSFQSKAAVFGASWNPVHAAGANAVPAAVYHHHHHPYVHPQAPVAAAAPDGRYMRSWLEPTPGALSFAGLPSSRPYGIKPEPLSARRGDCPTLDTHTLSLTDYACGSPPVDREKQPSEGAFSENNAENESGGDKPPIDPNNPAANWLHARSTRKKRCPYTKHQTLELEKEFLFNMYLTRDRRYEVARLLNLTERQVKIWFQNRRMKMKKINKDRAKDE

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
139	Symmetric dimethylarginine	KPEPLSARRGDCPTL CCCCCCCCCCCCCCC	39.47	-
139	Methylation	KPEPLSARRGDCPTL CCCCCCCCCCCCCCC	39.47	-
160	Phosphorylation	LTDYACGSPPVDREK CCCCCCCCCCCCCCC	26.39	22802335
183	Phosphorylation	ENNAENESGGDKPPI CCCCCCCCCCCCCCC	60.71	22802335
204	Phosphorylation	ANWLHARSTRKKRCP HHHHHHHHCCCCCCC	33.09	22817900
205	Phosphorylation	NWLHARSTRKKRCPY HHHHHHHCCCCCCCC	40.74	22817900

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
204	S	Phosphorylation	Kinase	PRKCA	P17252	GPS
205	T	Phosphorylation	Kinase	PRKCA	P17252	GPS

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
140	R	Methylation	Methylated on Arg-140 by PRMT5; methylation is critical for E-selectin induction.	-

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of HXA9_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
PAX6_MOUSE	Pax6	physical	20211142
PBX3_MOUSE	Pbx3	physical	20211142
PO2F1_MOUSE	Pou2f1	physical	20211142
NKX21_MOUSE	Nkx2-1	physical	20211142
RPB9_MOUSE	Polr2i	physical	20211142
TF2AY_MOUSE	Gtf2a1l	physical	20211142
JADE1_MOUSE	Jade1	physical	20211142
MEIS1_MOUSE	Meis1	physical	16087734
PBX1_MOUSE	Pbx1	physical	15161102
MEIS1_MOUSE	Meis1	physical	15161102
MEIS2_MOUSE	Meis2	physical	15161102

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.