HSH2D_HUMAN - dbPTM
HSH2D_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID HSH2D_HUMAN
UniProt AC Q96JZ2
Protein Name Hematopoietic SH2 domain-containing protein
Gene Name HSH2D
Organism Homo sapiens (Human).
Sequence Length 352
Subcellular Localization Cytoplasm. Nucleus.
Protein Description May be a modulator of the apoptotic response through its ability to affect mitochondrial stability (By similarity). Adapter protein involved in tyrosine kinase and CD28 signaling. Seems to affect CD28-mediated activation of the RE/AP element of the interleukin-2 promoter..
Protein Sequence MTEAGKLPLPLPPRLDWFVHTQMGQLAQDGVPEWFHGAISREDAENLLESQPLGSFLIRVSHSHVGYTLSYKAQSSCCHFMVKLLDDGTFMIPGEKVAHTSLDALVTFHQQKPIEPRRELLTQPCRQKDPANVDYEDLFLYSNAVAEEAACPVSAPEEASPKPVLCHQSKERKPSAEMNRITTKEATSSCPPKSPLGETRQKLWRSLKMLPERGQRVRQQLKSHLATVNLSSLLDVRRSTVISGPGTGKGSQDHSGDPTSGDRGYTDPCVATSLKSPSQPQAPKDRKVPTRKAERSVSCIEVTPGDRSWHQMVVRALSSQESKPEHQGLAEPENDQLPEEYQQPPPFAPGYC
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
63PhosphorylationFLIRVSHSHVGYTLS
EEEEEECCCCEEEEE		16.6228348404
89PhosphorylationVKLLDDGTFMIPGEK
EEECCCCCEECCCCE		19.6123403867
135PhosphorylationKDPANVDYEDLFLYS
CCCCCCCHHHHHHHH		13.6820736484
175PhosphorylationQSKERKPSAEMNRIT
CCCCCCCCHHHHCCC		39.6423401153
182PhosphorylationSAEMNRITTKEATSS
CHHHHCCCCHHHHHC		28.6930576142
183PhosphorylationAEMNRITTKEATSSC
HHHHCCCCHHHHHCC		25.2330576142
187PhosphorylationRITTKEATSSCPPKS
CCCCHHHHHCCCCCC		23.4323401153
188PhosphorylationITTKEATSSCPPKSP
CCCHHHHHCCCCCCC		36.6725849741
189PhosphorylationTTKEATSSCPPKSPL
CCHHHHHCCCCCCCC		26.7025849741
194PhosphorylationTSSCPPKSPLGETRQ
HHCCCCCCCCHHHHH		31.0023401153
199PhosphorylationPKSPLGETRQKLWRS
CCCCCHHHHHHHHHH		36.2829978859
206PhosphorylationTRQKLWRSLKMLPER
HHHHHHHHHCCCHHH		22.28-
223PhosphorylationRVRQQLKSHLATVNL
HHHHHHHHHHHCCCH		32.1229449344
227PhosphorylationQLKSHLATVNLSSLL
HHHHHHHCCCHHHHH		19.1129449344
231PhosphorylationHLATVNLSSLLDVRR
HHHCCCHHHHHHHHH		17.4629449344
232PhosphorylationLATVNLSSLLDVRRS
HHCCCHHHHHHHHHC		35.8029449344
239PhosphorylationSLLDVRRSTVISGPG
HHHHHHHCEEECCCC		19.2323312004
240PhosphorylationLLDVRRSTVISGPGT
HHHHHHCEEECCCCC		21.7623312004
243PhosphorylationVRRSTVISGPGTGKG
HHHCEEECCCCCCCC		34.3023312004
247PhosphorylationTVISGPGTGKGSQDH
EEECCCCCCCCCCCC		38.5623312004
249UbiquitinationISGPGTGKGSQDHSG
ECCCCCCCCCCCCCC		56.0529967540
251PhosphorylationGPGTGKGSQDHSGDP
CCCCCCCCCCCCCCC		35.6023312004
255PhosphorylationGKGSQDHSGDPTSGD
CCCCCCCCCCCCCCC		53.8623312004
259PhosphorylationQDHSGDPTSGDRGYT
CCCCCCCCCCCCCCC		50.51-
260PhosphorylationDHSGDPTSGDRGYTD
CCCCCCCCCCCCCCC		44.05-
265PhosphorylationPTSGDRGYTDPCVAT
CCCCCCCCCCCCEEC		14.6320090780
266PhosphorylationTSGDRGYTDPCVATS
CCCCCCCCCCCEECC		35.9721552520
272PhosphorylationYTDPCVATSLKSPSQ
CCCCCEECCCCCCCC		17.7528450419
273PhosphorylationTDPCVATSLKSPSQP
CCCCEECCCCCCCCC		24.8628450419
275UbiquitinationPCVATSLKSPSQPQA
CCEECCCCCCCCCCC		61.15-
276PhosphorylationCVATSLKSPSQPQAP
CEECCCCCCCCCCCC		34.7723401153
278PhosphorylationATSLKSPSQPQAPKD
ECCCCCCCCCCCCCC		62.6828450419
296PhosphorylationPTRKAERSVSCIEVT
CCCCCCCCEEEEEEC		15.1920058876
298PhosphorylationRKAERSVSCIEVTPG
CCCCCCEEEEEECCC		15.6023401153
303PhosphorylationSVSCIEVTPGDRSWH
CEEEEEECCCCCCHH		14.5726552605
308PhosphorylationEVTPGDRSWHQMVVR
EECCCCCCHHHHHHH		33.3826657352
318PhosphorylationQMVVRALSSQESKPE
HHHHHHHHCCCCCCC		29.0520471366
319PhosphorylationMVVRALSSQESKPEH
HHHHHHHCCCCCCCC		38.5327251275
322PhosphorylationRALSSQESKPEHQGL
HHHHCCCCCCCCCCC		45.9628348404
341PhosphorylationNDQLPEEYQQPPPFA
CCCCCHHHCCCCCCC		15.7027642862
351PhosphorylationPPPFAPGYC------
CCCCCCCCC------		8.2327642862
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of HSH2D_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of HSH2D_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of HSH2D_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
FES_HUMANFESphysical
11700021
ACK1_HUMANTNK2physical
11700021
MPP3_HUMANMPP3physical
21988832
LDH6B_HUMANLDHAL6Bphysical
25814554
PLPP6_HUMANPPAPDC2physical
25814554
RET7_HUMANRBP7physical
25814554
CNMD_HUMANLECT1physical
25814554
P55G_HUMANPIK3R3physical
25814554
PINK1_HUMANPINK1physical
25814554
TSC1_HUMANTSC1physical
25814554
OLIG1_HUMANOLIG1physical
25814554
ACK1_HUMANTNK2physical
25814554
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of HSH2D_HUMAN

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Related Literatures of Post-Translational Modification

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