| UniProt ID | DUS2_HUMAN | |
|---|---|---|
| UniProt AC | Q05923 | |
| Protein Name | Dual specificity protein phosphatase 2 | |
| Gene Name | DUSP2 | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 314 | |
| Subcellular Localization | Nucleus. | |
| Protein Description | Regulates mitogenic signal transduction by dephosphorylating both Thr and Tyr residues on MAP kinases ERK1 and ERK2.. | |
| Protein Sequence | MGLEAARELECAALGTLLRDPREAERTLLLDCRPFLAFCRRHVRAARPVPWNALLRRRARGPPAAVLACLLPDRALRTRLVRGELARAVVLDEGSASVAELRPDSPAHVLLAALLHETRAGPTAVYFLRGGFDGFQGCCPDLCSEAPAPALPPTGDKTSRSDSRAPVYDQGGPVEILPYLFLGSCSHSSDLQGLQACGITAVLNVSASCPNHFEGLFRYKSIPVEDNQMVEISAWFQEAIGFIDWVKNSGGRVLVHCQAGISRSATICLAYLMQSRRVRLDEAFDFVKQRRGVISPNFSFMGQLLQFETQVLCH | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 157 | Ubiquitination | ALPPTGDKTSRSDSR CCCCCCCCCCCCCCC | 50.15 | 21963094 | |
| 185 | Ubiquitination | PYLFLGSCSHSSDLQ CEEEECCCCCCCCCH | 3.94 | 22817900 | |
| 288 | Ubiquitination | DEAFDFVKQRRGVIS HHHHHHHHHHCCCCC | 37.77 | 21906983 | |
| 316 | Ubiquitination | TQVLCH--------- EECCCC--------- | 27667366 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of DUS2_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of DUS2_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of DUS2_HUMAN !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
| MK01_HUMAN | MAPK1 | physical | 27880917 | |
| DUS2_HUMAN | DUSP2 | physical | 27432908 | |
| MK14_HUMAN | MAPK14 | physical | 27432908 | |
| DUS3_HUMAN | DUSP3 | physical | 27432908 | |
| MK04_HUMAN | MAPK4 | physical | 27432908 | |
| TEBP_HUMAN | PTGES3 | physical | 27432908 | |
| MIA40_HUMAN | CHCHD4 | physical | 27432908 | |
| AP3S1_HUMAN | AP3S1 | physical | 27432908 | |
| T126A_HUMAN | TMEM126A | physical | 27432908 | |
| IF5A1_HUMAN | EIF5A | physical | 27432908 | |
| PARK7_HUMAN | PARK7 | physical | 27432908 | |
| PRDX5_HUMAN | PRDX5 | physical | 27432908 | |
| PPAC_HUMAN | ACP1 | physical | 27432908 | |
| MP2K3_HUMAN | MAP2K3 | physical | 27432908 | |
| ABHEB_HUMAN | ABHD14B | physical | 27432908 | |
| NDKA_HUMAN | NME1 | physical | 27432908 | |
| MK11_HUMAN | MAPK11 | physical | 27432908 | |
| FKBP5_HUMAN | FKBP5 | physical | 27432908 | |
| AIP_HUMAN | AIP | physical | 27432908 | |
| MK01_HUMAN | MAPK1 | physical | 27432908 | |
| UBL4A_HUMAN | UBL4A | physical | 27432908 | |
| VPS4A_HUMAN | VPS4A | physical | 27432908 | |
| THTPA_HUMAN | THTPA | physical | 27432908 |
| Kegg Disease | ||||||
|---|---|---|---|---|---|---|
| There are no disease associations of PTM sites. | ||||||
| OMIM Disease | ||||||
| There are no disease associations of PTM sites. | ||||||
| Kegg Drug | ||||||
| There are no disease associations of PTM sites. | ||||||
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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