DCTD_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: DCTD_HUMAN
• UniProt AC: P32321
• Protein Name: Deoxycytidylate deaminase
• Gene Name: DCTD
• Organism: Homo sapiens (Human).
• Sequence Length: 178
• Protein Description: Supplies the nucleotide substrate for thymidylate synthetase..
• Protein Sequence: MSEVSCKKRDDYLEWPEYFMAVAFLSAQRSKDPNSQVGACIVNSENKIVGIGYNGMPNGCSDDVLPWRRTAENKLDTKYPYVCHAELNAIMNKNSTDVKGCSMYVALFPCNECAKLIIQAGIKEVIFMSDKYHDSDEATAARLLFNMAGVTFRKFIPKCSKIVIDFDSINSRPSQKLQ

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
7	Ubiquitination	-MSEVSCKKRDDYLE -CCCCCCCCCCCCCC	43.25	33845483
12	Phosphorylation	SCKKRDDYLEWPEYF CCCCCCCCCCCHHHH	15.71	20736484
16 (in isoform 2)	Phosphorylation	-	19.62	29507054
18	Ubiquitination	DYLEWPEYFMAVAFL CCCCCHHHHHHHHHH	8.45	33845483
31	Ubiquitination	FLSAQRSKDPNSQVG HHHHHHCCCCCCCCE	78.41	33845483
35	Phosphorylation	QRSKDPNSQVGACIV HHCCCCCCCCEEEEE	31.47	27282143
42 (in isoform 2)	Ubiquitination	-	6.93	-
42	Ubiquitination	SQVGACIVNSENKIV CCCEEEEECCCCCEE	6.93	33845483
74	Acetylation	WRRTAENKLDTKYPY CHHHHCCCCCCCCCE	38.96	22424773
77	Phosphorylation	TAENKLDTKYPYVCH HHCCCCCCCCCEEEH	42.80	-
79	Phosphorylation	ENKLDTKYPYVCHAE CCCCCCCCCEEEHHH	11.24	19060867
91	Sulfoxidation	HAELNAIMNKNSTDV HHHHHHHHCCCCCCC	5.62	30846556
131	Malonylation	EVIFMSDKYHDSDEA EEEEECCCCCCCCHH	36.86	26320211
131	Acetylation	EVIFMSDKYHDSDEA EEEEECCCCCCCCHH	36.86	23236377
168	Phosphorylation	KIVIDFDSINSRPSQ EEEEEHHHHCCCCCC	24.54	23186163
171	Phosphorylation	IDFDSINSRPSQKLQ EEHHHHCCCCCCCCC	43.85	23186163
174	Phosphorylation	DSINSRPSQKLQ--- HHHCCCCCCCCC---	38.55	23186163

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of DCTD_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of DCTD_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of DCTD_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
LNX1_HUMAN	LNX1	physical	16189514
CEP76_HUMAN	CEP76	physical	16189514
NUD18_HUMAN	NUDT18	physical	16189514
NIF3L_HUMAN	NIF3L1	physical	16189514
DCTD_HUMAN	DCTD	physical	16189514
DCTD_HUMAN	DCTD	physical	21988832
FGF12_HUMAN	FGF12	physical	25416956
SDCB1_HUMAN	SDCBP	physical	25416956
THIOM_HUMAN	TXN2	physical	25416956
GORS2_HUMAN	GORASP2	physical	25416956
MASU1_HUMAN	MALSU1	physical	25416956
NGRN_HUMAN	NGRN	physical	26496610

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• DB00987: Cytarabine

Related Literatures of Post-Translational Modification

Phosphorylation

"Immunoaffinity profiling of tyrosine phosphorylation in cancercells.";
Rush J., Moritz A., Lee K.A., Guo A., Goss V.L., Spek E.J., Zhang H.,Zha X.-M., Polakiewicz R.D., Comb M.J.;
Nat. Biotechnol. 23:94-101(2005).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-79, AND MASSSPECTROMETRY.
PubMed: 15592455