DAZ1_HUMAN - dbPTM
DAZ1_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID DAZ1_HUMAN
UniProt AC Q9NQZ3
Protein Name Deleted in azoospermia protein 1
Gene Name DAZ1
Organism Homo sapiens (Human).
Sequence Length 744
Subcellular Localization Cytoplasm . Nucleus . Predominantly cytoplasmic. Nuclear at some stages of spermatozoide development. Localizes both to the nuclei and cytoplasm of spermatozoide differentiation. Nuclear in fetal gonocytes and in spermatogonial nuclei. It then reloca
Protein Description RNA-binding protein that plays an essential role in spermatogenesis. May act by binding to the 3'-UTR of mRNAs and regulating their translation. Promotes germ-cell progression to meiosis and formation of haploid germ cells..
Protein Sequence MSAANPETPNSTISREASTQSSSAAASQGWVLPEGKIVPNTVFVGGIDARMDETEIGSCFGRYGSVKEVKIITNRTGVSKGYGFVSFVNDVDVQKIVGSQIHFHGKKLKLGPAIRKQKLCARHVQPRPLVVNPPPPPQFQNVWRNPNTETYLQPQITPNPVTQHVQSAANPETPNSTISREASTQSSSAAASQGWVLPEGKIVPNTVFVGGIDARMDETEIGSCFGRYGSVKEVKIITNRTGVSKGYGFVSFVNDVDVQKIVGSQIHFHGKKLKLGPAIRKQKLCARHVQPRPLVVNPPPPPQFQNVWRNPNTETYLQPQITPNPVTQHVQSAANPETPNSTISREASTQSSSAAASQGWVLPEGKIVPNTVFVGGIDARMDETEIGSCFGRYGSVKEVKIITNRTGVSKGYGFVSFVNDVDVQKIVGSQIHFHGKKLKLGPAIRKQKLCARHVQPRPLVVNPPPPPQFQNVWRNPNTETYLQPQITPNPVTQHVQAYSAYPHSPGQVITGCQLLVYNYQEYPTYPDSAFQVTTGYQLPVYNYQPFPAYPRSPFQVTAGYQLPVYNYQAFPAYPNSPFQVATGYQFPVYNYQPFPAYPSSPFQVTAGYQLPVYNYQAFPAYPNSPFQVATGYQFPVYNYQAFPAYPNSPVQVTTGYQLPVYNYQAFPAYPSSPFQVTTGYQLPVYNYQAFPAYPNSAVQVTTGYQFHVYNYQMPPQCPVGEQRRNLWTEAYKWWYLVCLIQRRD
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
36UbiquitinationGWVLPEGKIVPNTVF
CEECCCCEECCCEEE		38.5821906983
36UbiquitinationGWVLPEGKIVPNTVF
CEECCCCEECCCEEE		38.5821906983
58PhosphorylationMDETEIGSCFGRYGS
CCCCCHHHHHCCCCC		16.3722210691
63PhosphorylationIGSCFGRYGSVKEVK
HHHHHCCCCCEEEEE		17.7128857561
65PhosphorylationSCFGRYGSVKEVKII
HHHCCCCCEEEEEEE		22.5328857561
67UbiquitinationFGRYGSVKEVKIITN
HCCCCCEEEEEEEEC		59.4921906983
67UbiquitinationFGRYGSVKEVKIITN
HCCCCCEEEEEEEEC		59.4921906983
70UbiquitinationYGSVKEVKIITNRTG
CCCEEEEEEEECCCC		29.49-
73PhosphorylationVKEVKIITNRTGVSK
EEEEEEEECCCCCCC		23.3228857561
80UbiquitinationTNRTGVSKGYGFVSF
ECCCCCCCCCCEEEE		54.4621906983
80UbiquitinationTNRTGVSKGYGFVSF
ECCCCCCCCCCEEEE		54.4621906983
95UbiquitinationVNDVDVQKIVGSQIH
ECCEEHHHHCCCEEE		38.9321906983
95UbiquitinationVNDVDVQKIVGSQIH
ECCEEHHHHCCCEEE		38.9321906983
106UbiquitinationSQIHFHGKKLKLGPA
CEEEECCEECCCCHH		46.4921906983
106UbiquitinationSQIHFHGKKLKLGPA
CEEEECCEECCCCHH		46.4921906983
107UbiquitinationQIHFHGKKLKLGPAI
EEEECCEECCCCHHH		56.2821906983
107UbiquitinationQIHFHGKKLKLGPAI
EEEECCEECCCCHHH		56.2821906983
109UbiquitinationHFHGKKLKLGPAIRK
EECCEECCCCHHHHH		61.35-
116UbiquitinationKLGPAIRKQKLCARH
CCCHHHHHHHHCCCC		45.7521906983
116UbiquitinationKLGPAIRKQKLCARH
CCCHHHHHHHHCCCC		45.7521906983
118UbiquitinationGPAIRKQKLCARHVQ
CHHHHHHHHCCCCCC		48.8721906983
118UbiquitinationGPAIRKQKLCARHVQ
CHHHHHHHHCCCCCC		48.8721906983
201UbiquitinationGWVLPEGKIVPNTVF
CEECCCCEECCCEEE		38.5821906983
223PhosphorylationMDETEIGSCFGRYGS
CCCCCHHHHHCCCCC		16.3722210691
228PhosphorylationIGSCFGRYGSVKEVK
HHHHHCCCCCEEEEE		17.7128857561
230PhosphorylationSCFGRYGSVKEVKII
HHHCCCCCEEEEEEE		22.5328857561
232UbiquitinationFGRYGSVKEVKIITN
HCCCCCEEEEEEEEC		59.4921906983
235UbiquitinationYGSVKEVKIITNRTG
CCCEEEEEEEECCCC		29.49-
238PhosphorylationVKEVKIITNRTGVSK
EEEEEEEECCCCCCC		23.3228857561
245UbiquitinationTNRTGVSKGYGFVSF
ECCCCCCCCCCEEEE		54.4621906983
260UbiquitinationVNDVDVQKIVGSQIH
ECCEEHHHHCCCEEE		38.9321906983
271UbiquitinationSQIHFHGKKLKLGPA
CEEEECCEECCCCHH		46.4921906983
272UbiquitinationQIHFHGKKLKLGPAI
EEEECCEECCCCHHH		56.2821906983
274UbiquitinationHFHGKKLKLGPAIRK
EECCEECCCCHHHHH		61.35-
281UbiquitinationKLGPAIRKQKLCARH
CCCHHHHHHHHCCCC		45.7521906983
283UbiquitinationGPAIRKQKLCARHVQ
CHHHHHHHHCCCCCC		48.8721906983
366UbiquitinationGWVLPEGKIVPNTVF
CEECCCCEECCCEEE		38.5821906983
388PhosphorylationMDETEIGSCFGRYGS
CCCCCHHHHHCCCCC		16.3722210691
393PhosphorylationIGSCFGRYGSVKEVK
HHHHHCCCCCEEEEE		17.7128857561
395PhosphorylationSCFGRYGSVKEVKII
HHHCCCCCEEEEEEE		22.5328857561
397UbiquitinationFGRYGSVKEVKIITN
HCCCCCEEEEEEEEC		59.4921906983
400UbiquitinationYGSVKEVKIITNRTG
CCCEEEEEEEECCCC		29.49-
403PhosphorylationVKEVKIITNRTGVSK
EEEEEEEECCCCCCC		23.3228857561
410UbiquitinationTNRTGVSKGYGFVSF
ECCCCCCCCCCEEEE		54.4621906983
425UbiquitinationVNDVDVQKIVGSQIH
ECCEEHHHHCCCEEE		38.9321906983
436UbiquitinationSQIHFHGKKLKLGPA
CEEEECCEECCCCHH		46.4921906983
437UbiquitinationQIHFHGKKLKLGPAI
EEEECCEECCCCHHH		56.2821906983
439UbiquitinationHFHGKKLKLGPAIRK
EECCEECCCCHHHHH		61.35-
446UbiquitinationKLGPAIRKQKLCARH
CCCHHHHHHHHCCCC		45.7521906983
448UbiquitinationGPAIRKQKLCARHVQ
CHHHHHHHHCCCCCC		48.872190698
560PhosphorylationPFQVTAGYQLPVYNY
CCEEEECEECEEEEE		12.38-
565PhosphorylationAGYQLPVYNYQAFPA
ECEECEEEEEEECCC		13.25-
567PhosphorylationYQLPVYNYQAFPAYP
EECEEEEEEECCCCC		5.41-
613PhosphorylationAGYQLPVYNYQAFPA
ECEECEEEEEEECCC		13.25-
615PhosphorylationYQLPVYNYQAFPAYP
EECEEEEEEECCCCC		5.41-
656PhosphorylationPVQVTTGYQLPVYNY
CCEEEECEECEEECE		12.56-
661PhosphorylationTGYQLPVYNYQAFPA
ECEECEEECEECCCC		13.25-
663PhosphorylationYQLPVYNYQAFPAYP
EECEEECEECCCCCC		5.41-
680PhosphorylationPFQVTTGYQLPVYNY
CCEEEECCEEEEEEE		12.56-
685PhosphorylationTGYQLPVYNYQAFPA
ECCEEEEEEEEECCC		13.25-
687PhosphorylationYQLPVYNYQAFPAYP
CEEEEEEEEECCCCC		5.41-
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of DAZ1_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of DAZ1_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of DAZ1_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
DAZP1_HUMANDAZAP1physical
10857750
DAZP2_HUMANDAZAP2physical
10857750
DAZ1_HUMANDAZ1physical
10857750
DAZL_HUMANDAZLphysical
10857750
PUM2_HUMANPUM2physical
12511597
QKI_HUMANQKIphysical
12511597
BOLL_HUMANBOLLphysical
12511597
DZIP1_HUMANDZIP1physical
12511597
DZI1L_HUMANDZIP1Lphysical
12511597
DZIP3_HUMANDZIP3physical
12511597
DAZL_HUMANDAZLphysical
12511597
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
415000Spermatogenic failure Y-linked 2 (SPGFY2)
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of DAZ1_HUMAN

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Related Literatures of Post-Translational Modification

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