DZI1L_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: DZI1L_HUMAN
• UniProt AC: Q8IYY4
• Protein Name: Zinc finger protein DZIP1L {ECO:0000305}
• Gene Name: DZIP1L {ECO:0000312|HGNC:HGNC:26551}
• Organism: Homo sapiens (Human).
• Sequence Length: 767
• Subcellular Localization: Cytoplasm, cytoskeleton, cilium basal body . Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole . Localizes to centrioles and to the distal ends of basal bodies (PubMed:28530676).
• Protein Description: Involved in primary cilium formation. [PubMed: 19852954]
• Protein Sequence: MQSPAATAEGLSGPLFGAYTFPTFKFQPRHDSMDWRRISTLDVDRVARELDVATLQENIAGITFCNLDREVCSRCGQPVDPALLKVLRLAQLIIEYLLHCQDCLSASVAQLEARLQTSLGQQQRGQQELGRQADELKGVREESRRRRKMISTLQQLLMQTGTHSYHTCHLCDKTFMNATFLRGHIQRRHAGVAEGGKQKKQEQPVEEVLEELRAKLKWTQGELEAQREAERQRQLQEAELIHQREIEAKKEFDKWKEQEWTKLYGEIDKLKKLFWDEFKNVAKQNSTLEEKLRALQSHSVMESKLGSLRDEESEEWLRQARELQALREKTEIQKTEWKRKVKELHEEHMAEKKELQEENQRLQASLSQDQKKAAAQSQCQISTLRAQLQEQARIIASQEEMIQSLSLRKVEGIHKVPKAVDTEEDSPEEEMEDSQDEQHKVLAALRRNPTLLKHFRPILEDTLEEKLESMGIRKDAKGISIQTLRHLESLLRVQREQKARKFSEFLSLRGKLVKEVTSRAKERQENGAVVSQPDGQPSVKSQQSTLVTREAQPKTRTLQVALPSTPAEPPPPTRQSHGSHGSSLTQVSAPAPRPGLHGPSSTPPSSGPGMSTPPFSSEEDSEGDRVQRVSLQPPKVPSRMVPRPKDDWDWSDTETSEENAQPPGQGSGTLVQSMVKNLEKQLEAPAKKPAGGVSLFFMPNAGPQRAATPGRKPQLSEDESDLEISSLEDLPLDLDQREKPKPLSRSKLPEKFGTGPQSSGQPRVPAW

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
3	Phosphorylation	-----MQSPAATAEG -----CCCCCCCCCC	18.40	27251275
39	Phosphorylation	SMDWRRISTLDVDRV CCCCCCCCCCCHHHH	22.55	22210691
40	Phosphorylation	MDWRRISTLDVDRVA CCCCCCCCCCHHHHH	25.30	22210691
63	Phosphorylation	QENIAGITFCNLDRE HHHHCCCEEECCCHH	22.63	22210691
200	Ubiquitination	AEGGKQKKQEQPVEE CCCCCHHCCCCCHHH	57.48	29967540
269	Ubiquitination	KLYGEIDKLKKLFWD HHHHHHHHHHHHHHH	68.79	22817900
271	Ubiquitination	YGEIDKLKKLFWDEF HHHHHHHHHHHHHHH	53.85	22817900
272 (in isoform 2)	Ubiquitination	-	60.39	21890473
272 (in isoform 1)	Ubiquitination	-	60.39	21890473
272	Ubiquitination	GEIDKLKKLFWDEFK HHHHHHHHHHHHHHH	60.39	21890473
272	Ubiquitination	GEIDKLKKLFWDEFK HHHHHHHHHHHHHHH	60.39	22817900
291	Ubiquitination	QNSTLEEKLRALQSH CCCCHHHHHHHHHHH	33.62	29967540
297	Ubiquitination	EKLRALQSHSVMESK HHHHHHHHHHHHHHH	20.69	22817900
299	Ubiquitination	LRALQSHSVMESKLG HHHHHHHHHHHHHHH	28.53	22817900
300	Ubiquitination	RALQSHSVMESKLGS HHHHHHHHHHHHHHC	4.06	21890473
307	Phosphorylation	VMESKLGSLRDEESE HHHHHHHCCCHHHHH	30.57	24719451
377	Phosphorylation	QKKAAAQSQCQISTL HHHHHHHHHHHHHHH	28.35	29449344
382	Phosphorylation	AQSQCQISTLRAQLQ HHHHHHHHHHHHHHH	8.77	29449344
383	Phosphorylation	QSQCQISTLRAQLQE HHHHHHHHHHHHHHH	23.15	29449344
404	Phosphorylation	SQEEMIQSLSLRKVE CHHHHHHHCCHHCCC	14.70	17081983
406	Phosphorylation	EEMIQSLSLRKVEGI HHHHHHCCHHCCCCC	31.23	17081983
426	Phosphorylation	AVDTEEDSPEEEMED CCCCCCCCCHHHHCC	37.17	29507054
600	Phosphorylation	RPGLHGPSSTPPSSG CCCCCCCCCCCCCCC	51.98	30206219
601	Phosphorylation	PGLHGPSSTPPSSGP CCCCCCCCCCCCCCC	48.33	30206219
602	Phosphorylation	GLHGPSSTPPSSGPG CCCCCCCCCCCCCCC	43.48	30206219
605	Phosphorylation	GPSSTPPSSGPGMST CCCCCCCCCCCCCCC	49.48	30206219
606	Phosphorylation	PSSTPPSSGPGMSTP CCCCCCCCCCCCCCC	55.57	30206219
611	Phosphorylation	PSSGPGMSTPPFSSE CCCCCCCCCCCCCCC	43.61	30206219
612	Phosphorylation	SSGPGMSTPPFSSEE CCCCCCCCCCCCCCC	26.53	30206219
616	Phosphorylation	GMSTPPFSSEEDSEG CCCCCCCCCCCCCCC	42.48	30206219
617	Phosphorylation	MSTPPFSSEEDSEGD CCCCCCCCCCCCCCC	45.44	30206219
621	Phosphorylation	PFSSEEDSEGDRVQR CCCCCCCCCCCCEEE	46.92	30206219
630	Phosphorylation	GDRVQRVSLQPPKVP CCCEEEEECCCCCCC	24.39	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of DZI1L_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of DZI1L_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of DZI1L_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
A4_HUMAN	APP	physical	21832049
SPERT_HUMAN	SPERT	physical	25416956

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.