DAZL_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: DAZL_HUMAN
• UniProt AC: Q92904
• Protein Name: Deleted in azoospermia-like
• Gene Name: DAZL
• Organism: Homo sapiens (Human).
• Sequence Length: 295
• Subcellular Localization: Cytoplasm. Nucleus. Predominantly cytoplasmic. Nuclear in spermatogonia until near the end of the meiotic prophase and cytoplasmic localization from then onward..
• Protein Description: RNA-binding protein, which is essential for gametogenesis in both males and females. Plays a central role during spermatogenesis. Acts by binding to the 3'-UTR of mRNA, specifically recognizing GUU triplets, and thereby regulating the translation of key transcripts (By similarity)..
• Protein Sequence: MSTANPETPNSTISREASTQSSSAATSQGYILPEGKIMPNTVFVGGIDVRMDETEIRSFFARYGSVKEVKIITDRTGVSKGYGFVSFFNDVDVQKIVESQINFHGKKLKLGPAIRKQNLCAYHVQPRPLVFNHPPPPQFQNVWTNPNTETYMQPTTTMNPITQYVQAYPTYPNSPVQVITGYQLPVYNYQMPPQWPVGEQRSYVVPPAYSAVNYHCNEVDPGAEVVPNECSVHEATPPSGNGPQKKSVDRSIQTVVSCLFNPENRLRNSVVTQDDYFKDKRVHHFRRSRAMLKSV

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Phosphorylation	------MSTANPETP ------CCCCCCCCC	35.91	24043423
3	Phosphorylation	-----MSTANPETPN -----CCCCCCCCCC	29.20	24043423
8	Phosphorylation	MSTANPETPNSTISR CCCCCCCCCCCCCCH	29.09	24043423
11	Phosphorylation	ANPETPNSTISREAS CCCCCCCCCCCHHHH	28.46	24043423
12	Phosphorylation	NPETPNSTISREAST CCCCCCCCCCHHHHC	29.61	24043423
14	Phosphorylation	ETPNSTISREASTQS CCCCCCCCHHHHCCC	24.94	24043423
65	Phosphorylation	SFFARYGSVKEVKII HHHHHHCCEEEEEEE	22.53	-
67	Ubiquitination	FARYGSVKEVKIITD HHHHCCEEEEEEEEC	59.49	21906983
107	Ubiquitination	QINFHGKKLKLGPAI EECCCCCEEECCHHH	56.28	21906983
109	Ubiquitination	NFHGKKLKLGPAIRK CCCCCEEECCHHHHH	61.35	-
269	Phosphorylation	PENRLRNSVVTQDDY CCHHHCCCCCCCCHH	16.13	26074081
272	Phosphorylation	RLRNSVVTQDDYFKD HHCCCCCCCCHHHCH	24.91	26074081
276	Phosphorylation	SVVTQDDYFKDKRVH CCCCCCHHHCHHHHH	22.33	26074081

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
65	S	Phosphorylation	Kinase	MAPKAPK2	P49137	PSP

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of DAZL_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of DAZL_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
DAZ1_HUMAN	DAZ1	physical	10903443
DAZL_HUMAN	DAZL	physical	10903443

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.