CUL3A_ARATH - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CUL3A_ARATH
• UniProt AC: Q9ZVH4
• Protein Name: Cullin-3A
• Gene Name: CUL3A
• Organism: Arabidopsis thaliana (Mouse-ear cress).
• Sequence Length: 732
• Protein Description: Component of the cullin-RING ubiquitin ligases (CRL), or CUL3-RBX1-BTB protein E3 ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. The functional specificity of the CRL complex depends on the BTB domain-containing protein as the susbstrate recognition component. Involved in embryo pattern formation and endosperm development. Required for the normal division and organization of the root stem cells and columella root cap cells. Regulates primary root growth by an unknown pathway, but in an ethylene-dependent manner. Functions in distal root patterning, by an ethylene-independent mechanism. Functionally redundant with CUL3B..
• Protein Sequence: MSNQKKRNFQIEAFKHRVVVDPKYADKTWQILERAIHQIYNQDASGLSFEELYRNAYNMVLHKFGEKLYTGFIATMTSHLKEKSKLIEAAQGGSFLEELNKKWNEHNKALEMIRDILMYMDRTYIESTKKTHVHPMGLNLWRDNVVHFTKIHTRLLNTLLDLVQKERIGEVIDRGLMRNVIKMFMDLGESVYQEDFEKPFLDASSEFYKVESQEFIESCDCGDYLKKSEKRLTEEIERVAHYLDAKSEEKITSVVEKEMIANHMQRLVHMENSGLVNMLLNDKYEDLGRMYNLFRRVTNGLVTVRDVMTSHLREMGKQLVTDPEKSKDPVEFVQRLLDERDKYDKIINTAFGNDKTFQNALNSSFEYFINLNARSPEFISLFVDDKLRKGLKGITDVDVEVILDKVMMLFRYLQEKDVFEKYYKQHLAKRLLSGKTVSDDAERSLIVKLKTECGYQFTSKLEGMFTDMKTSEDTMRGFYGSHPELSEGPTLIVQVLTTGSWPTQPAVPCNLPAEVSVLCEKFRSYYLGTHTGRRLSWQTNMGTADIKAIFGKGQKHELNVSTFQMCVLMLFNNSDRLSYKEIEQATEIPAADLKRCLQSLACVKGKNVIKKEPMSKDIGEEDLFVVNDKFTSKFYKVKIGTVVAQKETEPEKQETRQRVEEDRKPQIEAAIVRIMKSRKILDHNNIIAEVTKQLQPRFLANPTEIKKRIESLIERDFLERDSTDRKLYRYLA

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
247	Phosphorylation	AHYLDAKSEEKITSV HHHHCCCCHHHHHHH	53.35	22074104
380	Phosphorylation	ARSPEFISLFVDDKL CCCHHHHHHHHCHHH	22.52	19880383
679	Neddylation	VRIMKSRKILDHNNI HHHHHHCCCCCCCCH	55.50	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of CUL3A_ARATH !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CUL3A_ARATH !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CUL3A_ARATH !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
CSN2_ARATH	FUS12	physical	12615944
ETO1_ARATH	ETO1	physical	15118728
RBX1A_ARATH	RBX1	physical	15659098
BPM3_ARATH	BPM3	physical	15659098
ABAP1_ARATH	ABAP1	physical	15659098
Y1178_ARATH	AT1G21780	physical	15659098
Y4845_ARATH	AT4G08455	physical	15749712
Y1178_ARATH	AT1G21780	physical	15749712
BPM1_ARATH	BPM1	physical	15749712
Y1178_ARATH	AT1G21780	physical	15772280
BPM1_ARATH	BPM1	physical	15772280
BPM2_ARATH	BPM2	physical	15772280
BPM3_ARATH	BPM3	physical	15772280
BT5_ARATH	BT5	physical	15772280
Y1164_ARATH	AT1G01640	physical	15772280
Y5851_ARATH	AT5G48510	physical	15772280
BT3_ARATH	BT3	physical	15772280
BT2_ARATH	BT2	physical	15772280
BT1_ARATH	BT1	physical	15772280
RBX1A_ARATH	RBX1	physical	15772280
CUL1_ARATH	CUL1	physical	15772280
RBX1A_ARATH	RBX1	physical	16792691
RBX1A_ARATH	RBX1	physical	15749712
RPT3_ARATH	NPH3	physical	21990941
BPM1_ARATH	BPM1	physical	15618422
BPM3_ARATH	BPM3	physical	15618422
RBX1A_ARATH	RBX1	physical	15618422
NPR1_ARATH	NPR1	physical	19490895
CSN8_ARATH	COP9	physical	19490895
CSN4_ARATH	COP8	physical	19490895
CSN5A_ARATH	CSN5A	physical	19490895

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.