CHSTF_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CHSTF_HUMAN
• UniProt AC: Q7LFX5
• Protein Name: Carbohydrate sulfotransferase 15
• Gene Name: CHST15
• Organism: Homo sapiens (Human).
• Sequence Length: 561
• Subcellular Localization: Golgi apparatus membrane ; Single-pass type II membrane protein . A small fraction may also be present at the cell surface, where it acts as a B-cell receptor.
• Protein Description: Sulfotransferase that transfers sulfate from 3'-phosphoadenosine 5'-phosphosulfate (PAPS) to the C-6 hydroxyl group of the GalNAc 4-sulfate residue of chondroitin sulfate A and forms chondroitin sulfate E containing GlcA-GalNAc(4,6-SO(4)) repeating units. It also transfers sulfate to a unique non-reducing terminal sequence, GalNAc(4SO4)-GlcA(2SO4)-GalNAc(6SO4), to yield a highly sulfated structure similar to the structure found in thrombomodulin chondroitin sulfate. May also act as a B-cell receptor involved in BCR ligation-mediated early activation that mediate regulatory signals key to B-cell development and/or regulation of B-cell-specific RAG expression; however such results are unclear in vivo..
• Protein Sequence: MRHCINCCIQLLPDGAHKQQVNCQGGPHHGHQACPTCKGENKILFRVDSKQMNLLAVLEVRTEGNENWGGFLRFKKGKRCSLVFGLIIMTLVMASYILSGAHQELLISSPFHYGGFPSNPSLMDSENPSDTKEHHHQSSVNNISYMKDYPSIKLIINSITTRIEFTTRQLPDLEDLKKQELHMFSVIPNKFLPNSKSPCWYEEFSGQNTTDPYLTNSYVLYSKRFRSTFDALRKAFWGHLAHAHGKHFRLRCLPHFYIIGQPKCGTTDLYDRLRLHPEVKFSAIKEPHWWTRKRFGIVRLRDGLRDRYPVEDYLDLFDLAAHQIHQGLQASSAKEQSKMNTIIIGEASASTMWDNNAWTFFYDNSTDGEPPFLTQDFIHAFQPNARLIVMLRDPVERLYSDYLYFASSNKSADDFHEKVTEALQLFENCMLDYSLRACVYNNTLNNAMPVRLQVGLYAVYLLDWLSVFDKQQFLILRLEDHASNVKYTMHKVFQFLNLGPLSEKQEALMTKSPASNARRPEDRNLGPMWPITQKILRDFYRPFNARLAQVLADEAFAWKTT

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
49	Phosphorylation	KILFRVDSKQMNLLA EEEEEECCCCCEEEE	23.17	29514088
118	O-linked_Glycosylation	FHYGGFPSNPSLMDS CCCCCCCCCHHHCCC	60.14	OGP
160	Phosphorylation	KLIINSITTRIEFTT EEHHHHHHHCCEEEC	15.16	-
161	Phosphorylation	LIINSITTRIEFTTR EHHHHHHHCCEEECC	28.16	-
201	Phosphorylation	NSKSPCWYEEFSGQN CCCCCCCCCCCCCCC	16.58	-
213	Phosphorylation	GQNTTDPYLTNSYVL CCCCCCCCCCCEEEE	29.03	-
217	Phosphorylation	TDPYLTNSYVLYSKR CCCCCCCEEEEEEHH	16.04	17081983
218	Phosphorylation	DPYLTNSYVLYSKRF CCCCCCEEEEEEHHH	9.13	22817900
221	Phosphorylation	LTNSYVLYSKRFRST CCCEEEEEEHHHHHH	11.34	17081983
222	Phosphorylation	TNSYVLYSKRFRSTF CCEEEEEEHHHHHHH	17.13	17081983
364	N-linked_Glycosylation	AWTFFYDNSTDGEPP CEEEEECCCCCCCCC	35.12	UniProtKB CARBOHYD
434	Phosphorylation	ENCMLDYSLRACVYN HHHHHCHHHHHHHHC	15.85	24719451
443	Phosphorylation	RACVYNNTLNNAMPV HHHHHCCCCCCCCCC	27.50	24719451
504	Ubiquitination	NLGPLSEKQEALMTK CCCCCCHHHHHHHCC	50.49	21906983
504 (in isoform 1)	Ubiquitination	-	50.49	21906983
510	Phosphorylation	EKQEALMTKSPASNA HHHHHHHCCCCCCCC	29.26	22210691
511	Ubiquitination	KQEALMTKSPASNAR HHHHHHCCCCCCCCC	40.24	2190698
511 (in isoform 1)	Ubiquitination	-	40.24	21906983

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of CHSTF_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CHSTF_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CHSTF_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
HCK_HUMAN	HCK	physical	10749872
CALX_HUMAN	CANX	physical	26496610
CCNB1_HUMAN	CCNB1	physical	26496610
IF5A1_HUMAN	EIF5A	physical	26496610
ZEP1_HUMAN	HIVEP1	physical	26496610
LGAT1_HUMAN	LPGAT1	physical	26496610
CEPT1_HUMAN	CEPT1	physical	26496610
SYFM_HUMAN	FARS2	physical	26496610
CASC3_HUMAN	CASC3	physical	26496610
RB6I2_HUMAN	ERC1	physical	26496610
KLDC2_HUMAN	KLHDC2	physical	26496610
S43A3_HUMAN	SLC43A3	physical	26496610
RABL6_HUMAN	RABL6	physical	26496610
PKHG1_HUMAN	PLEKHG1	physical	26496610
TPC_HUMAN	SLC25A19	physical	26496610
S35E1_HUMAN	SLC35E1	physical	26496610
ILKAP_HUMAN	ILKAP	physical	26496610
PHF5A_HUMAN	PHF5A	physical	26496610
NDUF2_HUMAN	NDUFAF2	physical	26496610
TJAP1_HUMAN	TJAP1	physical	26496610
CALX_HUMAN	CANX	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.