| UniProt ID | CHIP_ARATH | |
|---|---|---|
| UniProt AC | Q9SRS9 | |
| Protein Name | E3 ubiquitin-protein ligase CHIP {ECO:0000305} | |
| Gene Name | CHIP {ECO:0000303|PubMed:20028838} | |
| Organism | Arabidopsis thaliana (Mouse-ear cress). | |
| Sequence Length | 278 | |
| Subcellular Localization | ||
| Protein Description | Has E3 ubiquitin-protein ligase activity and may target misfolded substrates towards proteasomal degradation. Regulates the activity of some serine/threonine-protein phosphatases by E3 ubiquitin-protein ligase activity. Required for responses to biotic and abiotic stresses such as auxin, abscisic acid (ABA), low and high temperature and darkness, probably through the activation of serine/threonine-protein phosphatase and the subsequent modification of the plasma membrane composition. Regulates the chloroplastic Clp proteolytic activity in response to stresses. Ubiquitylates FtsH1, a component of the chloroplast FtsH protease, and affects protein degradation in chloroplasts. Mediates plastid precursor degradation to prevent cytosolic precursor accumulation, together with the molecular chaperone HSC70-4. Mediates ubiquitination of transit peptides and thereby led to their degradation through the ubiquitin-proteasome system.. | |
| Protein Sequence | MVTGVASAMAERLKEDGNNCFKKERFGAAIDAYTEAIALSPNVPAYWTNRALCHMKRKDWTKVEEDCRKAIQLVHNSVKAHYMLGLALLQKKEFTNGVKELQRALDLGRCSNPTGYMVEEIWEELSKAKYMEWELVSAMRSWELNSLKETCEAALNQQRALDMSRTEESSDEAYTAHTERLKALERVFKKAAEEDKPTEVPDYLCCNITLEIFRDPVISPSGVTYERAAILEHLKKVGKFDPITREKIDPANLVPNLAIKEAVAAYLEKHVWAYKMGC | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 9 | Sulfoxidation | VTGVASAMAERLKED CCHHHHHHHHHHHHC | 3.54 | 25693801 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of CHIP_ARATH !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of CHIP_ARATH !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of CHIP_ARATH !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
| UBC8_ARATH | UBC8 | physical | 16640601 | |
| UBC9_ARATH | UBC9 | physical | 16640601 | |
| UBC10_ARATH | UBC10 | physical | 16640601 | |
| R27AC_ARATH | UBQ5 | physical | 16640601 | |
| 2AAG_ARATH | PP2AA3 | physical | 16640601 | |
| FTSH1_ARATH | FTSH1 | physical | 16640601 | |
| CLPP4_ARATH | CLPP4 | physical | 16640601 | |
| RBS3B_ARATH | AT5G38410 | physical | 16640601 | |
| 2AAA_ARATH | RCN1 | physical | 16640601 | |
| MD37C_ARATH | HSP70 | physical | 20028838 | |
| FTSH1_ARATH | FTSH1 | physical | 17714429 | |
| MD37C_ARATH | HSP70 | physical | 17714429 | |
| CLPP4_ARATH | CLPP4 | physical | 17241447 | |
| ODPA1_ARATH | E1 ALPHA | physical | 24846764 | |
| ODP24_ARATH | LTA2 | physical | 24846764 | |
| CLPP3_ARATH | CLPP3 | physical | 26085677 | |
| CLPP5_ARATH | CLPP5 | physical | 26085677 |
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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