ODPA1_ARATH - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ODPA1_ARATH
• UniProt AC: P52901
• Protein Name: Pyruvate dehydrogenase E1 component subunit alpha-1, mitochondrial
• Gene Name: E1 ALPHA
• Organism: Arabidopsis thaliana (Mouse-ear cress).
• Sequence Length: 389
• Subcellular Localization: Mitochondrion matrix .
• Protein Description: The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It contains multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3)..
• Protein Sequence: MALSRLSSRSNIITRPFSAAFSRLISTDTTPITIETSLPFTAHLCDPPSRSVESSSQELLDFFRTMALMRRMEIAADSLYKAKLIRGFCHLYDGQEAVAIGMEAAITKKDAIITAYRDHCIFLGRGGSLHEVFSELMGRQAGCSKGKGGSMHFYKKESSFYGGHGIVGAQVPLGCGIAFAQKYNKEEAVTFALYGDGAANQGQLFEALNISALWDLPAILVCENNHYGMGTAEWRAAKSPSYYKRGDYVPGLKVDGMDAFAVKQACKFAKQHALEKGPIILEMDTYRYHGHSMSDPGSTYRTRDEISGVRQERDPIERIKKLVLSHDLATEKELKDMEKEIRKEVDDAIAKAKDCPMPEPSELFTNVYVKGFGTESFGPDRKEVKASLP

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
81	Acetylation	IAADSLYKAKLIRGF HHHHHHHHHHHHHCC	44.32	24727099
239	Phosphorylation	AEWRAAKSPSYYKRG HHHHCCCCCCHHCCC	17.85	25561503
288	Phosphorylation	LEMDTYRYHGHSMSD EEEECEEECCCCCCC	11.18	23776212
292	Phosphorylation	TYRYHGHSMSDPGST CEEECCCCCCCCCCC	25.27	27532006
293	Sulfoxidation	YRYHGHSMSDPGSTY EEECCCCCCCCCCCC	4.34	10
294	Phosphorylation	RYHGHSMSDPGSTYR EECCCCCCCCCCCCC	43.60	24601666
298	Phosphorylation	HSMSDPGSTYRTRDE CCCCCCCCCCCCHHH	27.88	23776212
299	Phosphorylation	SMSDPGSTYRTRDEI CCCCCCCCCCCHHHH	23.96	23776212
300	Phosphorylation	MSDPGSTYRTRDEIS CCCCCCCCCCHHHHC	16.22	23776212
332	Acetylation	SHDLATEKELKDMEK CCCCCCHHHHHHHHH	65.08	24727099

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of ODPA1_ARATH !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ODPA1_ARATH !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ODPA1_ARATH !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
ODPB1_ARATH	MAB1	physical	21798944
CHIP_ARATH	CHIP	physical	24846764

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.