FTSH1_ARATH - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: FTSH1_ARATH
• UniProt AC: Q39102
• Protein Name: ATP-dependent zinc metalloprotease FTSH 1, chloroplastic
• Gene Name: FTSH1
• Organism: Arabidopsis thaliana (Mouse-ear cress).
• Sequence Length: 716
• Subcellular Localization: Plastid, chloroplast thylakoid membrane ; Single-pass membrane protein ; Stromal side .
• Protein Description: Part of a complex that function as an ATP-dependent zinc metallopeptidase. Involved in the thylakoid formation and in the removal of damaged D1 in the photosystem II, preventing cell death under high-intensity light conditions..
• Protein Sequence: MASNSLLRSSSNFFLGSHIIISSPTPKTTRKPSFPFSFVSRAKYQITRSSQDENSPNGKPNSPFSSQVALAAILLSSISSSPLALAVVDEPASPSVVIESQAVKPSTPSPLFIQNEILKAPSPKSSDLPEGSQWRYSEFLNAVKKGKVERVRFSKDGSVVQLTAVDNRRASVIVPNDPDLIDILAMNGVDISVSEGESSGNDLFTVIGNLIFPLLAFGGLFLLFRRAQGGPGGGPGGLGGPMDFGRSKSKFQEVPETGVSFADVAGADQAKLELQEVVDFLKNPDKYTALGAKIPKGCLLVGPPGTGKTLLARAVAGEAGVPFFSCAASEFVELFVGVGASRVRDLFEKAKSKAPCIVFIDEIDAVGRQRGAGMGGGNDEREQTINQLLTEMDGFSGNSGVIVLAATNRPDVLDSALLRPGRFDRQVTVDRPDVAGRVKILQVHSRGKALGKDVDFDKVARRTPGFTGADLQNLMNEAAILAARRELKEISKDEISDALERIIAGPEKKNAVVSEEKKRLVAYHEAGHALVGALMPEYDPVAKISIIPRGQAGGLTFFAPSEERLESGLYSRSYLENQMAVALGGRVAEEVIFGDENVTTGASNDFMQVSRVARQMIERFGFSKKIGQVAVGGPGGNPFMGQQMSSQKDYSMATADIVDAEVRELVEKAYKRATEIITTHIDILHKLAQLLIEKETVDGEEFMSLFIDGQAELYIS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
5	Phosphorylation	---MASNSLLRSSSN ---CCCHHCCCCCCC	26.70	19880383
247	Phosphorylation	GPMDFGRSKSKFQEV CCCCCCCCHHHCCCC	41.48	19880383
249	Phosphorylation	MDFGRSKSKFQEVPE CCCCCCHHHCCCCCC	39.69	19880383
428	Phosphorylation	GRFDRQVTVDRPDVA CCCCCEEEECCCCCC	14.35	29654922

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
-	K	Ubiquitination	E3 ubiquitin ligase	CHIP	Q9SRS9	PMID:22199232

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of FTSH1_ARATH !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of FTSH1_ARATH !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
MD37C_ARATH	HSP70	physical	17714429

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.