ODP24_ARATH - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ODP24_ARATH
• UniProt AC: Q9SQI8
• Protein Name: Dihydrolipoyllysine-residue acetyltransferase component 4 of pyruvate dehydrogenase complex, chloroplastic
• Gene Name: LTA2
• Organism: Arabidopsis thaliana (Mouse-ear cress).
• Sequence Length: 480
• Subcellular Localization: Plastid, chloroplast stroma .
• Protein Description: The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It contains multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3) (By similarity)..
• Protein Sequence: MAVSSSSFLSTASLTNSKSNISFASSVSPSLRSVVFRSTTPATSHRRSMTVRSKIREIFMPALSSTMTEGKIVSWIKTEGEKLAKGESVVVVESDKADMDVETFYDGYLAAIVVGEGETAPVGAAIGLLAETEAEIEEAKSKAASKSSSSVAEAVVPSPPPVTSSPAPAIAQPAPVTAVSDGPRKTVATPYAKKLAKQHKVDIESVAGTGPFGRITASDVETAAGIAPSKSSIAPPPPPPPPVTAKATTTNLPPLLPDSSIVPFTAMQSAVSKNMIESLSVPTFRVGYPVNTDALDALYEKVKPKGVTMTALLAKAAGMALAQHPVVNASCKDGKSFSYNSSINIAVAVAINGGLITPVLQDADKLDLYLLSQKWKELVGKARSKQLQPHEYNSGTFTLSNLGMFGVDRFDAILPPGQGAIMAVGASKPTVVADKDGFFSVKNTMLVNVTADHRIVYGADLAAFLQTFAKIIENPDSLTL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
96	N6-lipoyllysine	VVVVESDKADMDVET EEEEECCCCCCCHHH		-
96	Lipoylation	VVVVESDKADMDVET EEEEECCCCCCCHHH		-
96	Lipoylation	VVVVESDKADMDVET EEEEECCCCCCCHHH		-
218	Phosphorylation	PFGRITASDVETAAG CCCEEEHHHHHCCCC		30291188
222	Phosphorylation	ITASDVETAAGIAPS EEHHHHHCCCCCCCC		19880383
229	Phosphorylation	TAAGIAPSKSSIAPP CCCCCCCCCCCCCCC		19880383
265	Phosphorylation	DSSIVPFTAMQSAVS CCCCCCCHHCCHHHH		25368622
269	Phosphorylation	VPFTAMQSAVSKNMI CCCHHCCHHHHHHHH		25368622
272	Phosphorylation	TAMQSAVSKNMIESL HHCCHHHHHHHHHHC		25368622

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of ODP24_ARATH !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ODP24_ARATH !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ODP24_ARATH !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
CHIP_ARATH	CHIP	physical	24846764
ODP24_ARATH	LTA2	physical	24846799

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.