CCD68_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CCD68_HUMAN
• UniProt AC: Q9H2F9
• Protein Name: Coiled-coil domain-containing protein 68
• Gene Name: CCDC68
• Organism: Homo sapiens (Human).
• Sequence Length: 335
• Subcellular Localization: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole . Localizes to the subdistal appendages of centrioles (PubMed:28422092).
• Protein Description: Centriolar protein required for centriole subdistal appendage assembly and microtubule anchoring in interphase cells. [PubMed: 28422092 Together with CCDC120, cooperate with subdistal appendage components ODF2, NIN and CEP170 for hierarchical subdistal appendage assembly]
• Protein Sequence: MTTVTVTTEIPPRDKMEDNSALYESTSAHIIEETEYVKKIRTTLQKIRTQMFKDEIRHDSTNHKLDAKHCGNLQQGSDSEMDPSCCSLDLLMKKIKGKDLQLLEMNKENEVLKIKLQASREAGAAALRNVAQRLFENYQTQSEEVRKKQEDSKQLLQVNKLEKEQKLKQHVENLNQVAEKLEEKHSQITELENLVQRMEKEKRTLLERKLSLENKLLQLKSSATYGKSCQDLQREISILQEQISHLQFVIHSQHQNLRSVIQEMEGLKNNLKEQDKRIENLREKVNILEAQNKELKTQVALSSETPRTKVSKAVSTSELKTEGVSPYLMLIRLRK

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
49	Phosphorylation	TTLQKIRTQMFKDEI HHHHHHHHHHHHHHH	28.05	29457462
94	Acetylation	SLDLLMKKIKGKDLQ HHHHHHHHHCCCHHH	35.37	10929553
119	Phosphorylation	LKIKLQASREAGAAA EEEEHHHHHHHHHHH	20.07	-
211	Phosphorylation	TLLERKLSLENKLLQ HHHHHHHHHHHHHHH	36.35	24702127
297	Phosphorylation	AQNKELKTQVALSSE HHCHHHHHHHHHCCC	40.68	22817900
327	Phosphorylation	KTEGVSPYLMLIRLR HCCCCCCEEHHHHHC	9.38	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of CCD68_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CCD68_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CCD68_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
RSSA_HUMAN	RPSA	physical	22939629
RS21_HUMAN	RPS21	physical	22939629
FYCO1_HUMAN	FYCO1	physical	26186194
PLEC_HUMAN	PLEC	physical	26186194
AKAP9_HUMAN	AKAP9	physical	26186194
CENPF_HUMAN	CENPF	physical	26186194
F16P1_HUMAN	FBP1	physical	26186194
CE170_HUMAN	CEP170	physical	26186194
NDC80_HUMAN	NDC80	physical	26186194
RBGP1_HUMAN	RABGAP1	physical	26186194
NIN_HUMAN	NIN	physical	26186194
FYCO1_HUMAN	FYCO1	physical	28514442
CENPF_HUMAN	CENPF	physical	28514442
NDC80_HUMAN	NDC80	physical	28514442
F16P1_HUMAN	FBP1	physical	28514442
NIN_HUMAN	NIN	physical	28514442
PLEC_HUMAN	PLEC	physical	28514442
RBGP1_HUMAN	RABGAP1	physical	28514442
BT3A2_HUMAN	BTN3A2	physical	28514442
CE170_HUMAN	CEP170	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.