BT3A2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: BT3A2_HUMAN
• UniProt AC: P78410
• Protein Name: Butyrophilin subfamily 3 member A2
• Gene Name: BTN3A2
• Organism: Homo sapiens (Human).
• Sequence Length: 334
• Subcellular Localization: Cell membrane ; Single-pass type I membrane protein .
• Protein Description: Plays a role in T-cell responses in the adaptive immune response. Inhibits the release of IFNG from activated T-cells..
• Protein Sequence: MKMASSLAFLLLNFHVSLLLVQLLTPCSAQFSVLGPSGPILAMVGEDADLPCHLFPTMSAETMELKWVSSSLRQVVNVYADGKEVEDRQSAPYRGRTSILRDGITAGKAALRIHNVTASDSGKYLCYFQDGDFYEKALVELKVAALGSNLHVEVKGYEDGGIHLECRSTGWYPQPQIQWSNAKGENIPAVEAPVVADGVGLYEVAASVIMRGGSGEGVSCIIRNSLLGLEKTASISIADPFFRSAQPWIAALAGTLPILLLLLAGASYFLWRQQKEITALSSEIESEQEMKEMGYAATEREISLRESLQEELKRKKIQYLTRGEESSSDTNKSA

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
70	Phosphorylation	MELKWVSSSLRQVVN HHHHHHHHHHHHHHE	24.63	25954137
71	Phosphorylation	ELKWVSSSLRQVVNV HHHHHHHHHHHHHEE	21.77	25954137
83	Ubiquitination	VNVYADGKEVEDRQS HEEEECCCCCCCCCC	60.16	2190698
98	Phosphorylation	APYRGRTSILRDGIT CCCCCCCCHHHCCCC	20.47	24719451
108	Ubiquitination	RDGITAGKAALRIHN HCCCCCCCHHHEEEE	28.20	-
112	Methylation	TAGKAALRIHNVTAS CCCCHHHEEEEEECC	24.32	-
115	N-linked_Glycosylation	KAALRIHNVTASDSG CHHHEEEEEECCCCC	30.39	UniProtKB CARBOHYD
123	Ubiquitination	VTASDSGKYLCYFQD EECCCCCCEEEEEEC	38.71	-
231	Ubiquitination	NSLLGLEKTASISIA CCCCCCEECEEEEEC	55.20	-
278	Phosphorylation	WRQQKEITALSSEIE HHHHHHHHHHHHHCC	23.72	28060719
281	Phosphorylation	QKEITALSSEIESEQ HHHHHHHHHHCCCHH	24.38	28060719
282	Phosphorylation	KEITALSSEIESEQE HHHHHHHHHCCCHHH	43.36	26657352
286	Phosphorylation	ALSSEIESEQEMKEM HHHHHCCCHHHHHHH	50.68	25159151
295	Phosphorylation	QEMKEMGYAATEREI HHHHHHCCHHHHHHH	7.55	28796482
313	Ubiquitination	ESLQEELKRKKIQYL HHHHHHHHHHHCHHH	66.50	-
316	Ubiquitination	QEELKRKKIQYLTRG HHHHHHHHCHHHHCC	38.79	-
319	Phosphorylation	LKRKKIQYLTRGEES HHHHHCHHHHCCCCC	17.32	26074081
321	Phosphorylation	RKKIQYLTRGEESSS HHHCHHHHCCCCCCC	31.52	26074081
326	Phosphorylation	YLTRGEESSSDTNKS HHHCCCCCCCCCCCC	30.73	26074081
327	Phosphorylation	LTRGEESSSDTNKSA HHCCCCCCCCCCCCC	35.20	26074081
328	Phosphorylation	TRGEESSSDTNKSA- HCCCCCCCCCCCCC-	58.70	26074081

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of BT3A2_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of BT3A2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of BT3A2_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
BT3A3_HUMAN	BTN3A3	physical	26186194
BT3A1_HUMAN	BTN3A1	physical	26186194
AT5G1_HUMAN	ATP5G1	physical	26186194
PEX13_HUMAN	PEX13	physical	26186194
BT3A3_HUMAN	BTN3A3	physical	28514442
BT3A1_HUMAN	BTN3A1	physical	28514442
PEX13_HUMAN	PEX13	physical	28514442
AT5G1_HUMAN	ATP5G1	physical	28514442
TM245_HUMAN	TMEM245	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Quantitative phosphoproteomic analysis of T cell receptor signalingreveals system-wide modulation of protein-protein interactions.";
Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,Rodionov V., Han D.K.;
Sci. Signal. 2:RA46-RA46(2009).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-282 AND SER-286, ANDMASS SPECTROMETRY.
PubMed: 19690332